Histone Chaperone Nrp1 Mutation Affects the Acetylation of H3K56 in Tetrahymena thermophila [PDF]
Cells, 2022 Histone modification and nucleosome assembly are mainly regulated by various histone-modifying enzymes and chaperones. The roles of histone-modification enzymes have been well analyzed, but the molecular mechanism of histone chaperones in histone ...
Yinjie Lian +4 more
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Histone acetylation-independent transcription stimulation by a histone chaperone [PDF]
Nucleic Acids Research, 2006 Histone chaperones are thought to be important for maintaining the physiological activity of histones; however, their exact roles are not fully understood. The physiological function of template activating factor (TAF)-I, one of the histone chaperones, also remains unclear; however, its biochemical properties have been well studied.
Kato, Kohsuke +3 more
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TSPY-like 2, Beyond the Histone Chaperone Role [PDF]
BiomoleculesChromatin is a dynamic cellular structure basically constituted by nucleosomes, which consist of a DNA sequence wrapped around an octameric histones core.
Emanuele Bonenti +3 more
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The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A [PDF]
Cell Reports, 2023 Summary: All vertebrate genomes encode for three large histone H2A variants that have an additional metabolite-binding globular macrodomain module, macroH2A. MacroH2A variants impact heterochromatin organization and transcription regulation and establish
Imke K. Mandemaker +9 more
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Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release [PDF]
Nature Communications, 2017 The histone chaperone nucleoplasmin (Npm) stores histones H2A/H2B in the egg and embryo. Here, the authors use NMR to show that Npm’s intrinsically disordered tail domain controls histone binding at an acidic stretch, which is autoregulated through ...
Christopher Warren +8 more
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New chaps in the histone chaperone arena [PDF]
Genes & Development, 2010 Understanding exactly how chromatin is assembled is paramount to addressing how select histone modifications may be transmitted, a putative epigenetic process. In the June 15, 2010, issue of Genes & Development, Drané and colleagues (pp. 1253–1265) identified DAXX as a novel H3.3-specific chaperone.
Eric I, Campos, Danny, Reinberg
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Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape [PDF]
Cell Reports, 2013 The HIRA chaperone complex, comprised of HIRA, UBN1, and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner.
Nikolay A. Pchelintsev +6 more
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Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast [PDF]
Nature Communications, 2018 Dot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed regions.
Soyun Lee +9 more
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DNA Repair Factor APLF Is a Histone Chaperone [PDF]
Molecular Cell, 2011 Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it regulates chromatin relaxation as one of the critical events in the repair process. However, the molecular mechanism by which poly(ADP-ribose) modulates chromatin remains poorly understood.
Mehrotra, Pawan Vinod +7 more
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The effects of the histone chaperone and histone modifications on nucleosome structure [PDF]
, 2016 The nucleosome, composed of 147-bp DNA and a histone octamer, is the basic unit of chromatin in eukaryotes, which is considered as a barrier for all DNA dependent processes. Understanding how nucleosome structure is regulated provides new insights into pivotal cellular processes.
Wang, Tao, author +4 more
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