Results 21 to 30 of about 31,898 (266)
The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states [PDF]
Cell Reports, 2021 Summary: Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle.
Magdalena Murawska +7 more
doaj +2 more sources
The histone chaperone function of Daxx is dispensable for embryonic development [PDF]
Cell Death and Disease, 2023 Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form a protein complex that deposits H3.3 into heterochromatic regions of the genome, including centromeres ...
Chang Sun +6 more
doaj +2 more sources
Histone Chaperone Nrp1 Mutation Affects the Acetylation of H3K56 in Tetrahymena thermophila [PDF]
Cells, 2022 Histone modification and nucleosome assembly are mainly regulated by various histone-modifying enzymes and chaperones. The roles of histone-modification enzymes have been well analyzed, but the molecular mechanism of histone chaperones in histone ...
Yinjie Lian +4 more
doaj +2 more sources
Histone acetylation-independent transcription stimulation by a histone chaperone [PDF]
Nucleic Acids Research, 2006 Histone chaperones are thought to be important for maintaining the physiological activity of histones; however, their exact roles are not fully understood. The physiological function of template activating factor (TAF)-I, one of the histone chaperones, also remains unclear; however, its biochemical properties have been well studied.
Kato, Kohsuke +3 more
openaire +3 more sources
TSPY-like 2, Beyond the Histone Chaperone Role [PDF]
BiomoleculesChromatin is a dynamic cellular structure basically constituted by nucleosomes, which consist of a DNA sequence wrapped around an octameric histones core.
Emanuele Bonenti +3 more
doaj +2 more sources
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A [PDF]
Cell Reports, 2023 Summary: All vertebrate genomes encode for three large histone H2A variants that have an additional metabolite-binding globular macrodomain module, macroH2A. MacroH2A variants impact heterochromatin organization and transcription regulation and establish
Imke K. Mandemaker +9 more
doaj +2 more sources
Nature Communications, 2017 The histone chaperone nucleoplasmin (Npm) stores histones H2A/H2B in the egg and embryo. Here, the authors use NMR to show that Npm’s intrinsically disordered tail domain controls histone binding at an acidic stretch, which is autoregulated through ...
Christopher Warren +8 more
doaj +2 more sources
New chaps in the histone chaperone arena [PDF]
Genes & Development, 2010 Understanding exactly how chromatin is assembled is paramount to addressing how select histone modifications may be transmitted, a putative epigenetic process. In the June 15, 2010, issue of Genes & Development, Drané and colleagues (pp. 1253–1265) identified DAXX as a novel H3.3-specific chaperone.
Eric I, Campos, Danny, Reinberg
openaire +3 more sources
Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape
Cell Reports, 2013 The HIRA chaperone complex, comprised of HIRA, UBN1, and CABIN1, collaborates with histone-binding protein ASF1a to incorporate histone variant H3.3 into chromatin in a DNA replication-independent manner.
Nikolay A. Pchelintsev +6 more
doaj +2 more sources
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis [PDF]
EMBO Journal, 2013 Histone chaperones affect chromatin structure and gene expression through interaction with histones and RNA polymerase II (PolII). Here, we report that the histone chaperone Spt6 counteracts H3K27me3, an epigenetic mark deposited by the Polycomb Repressive Complex 2 (PRC2) and associated with transcriptional repression.
Hossein Zare +2 more
exaly +3 more sources