Histone Chaperones as Cardinal Players in Development [PDF]
Frontiers in Cell and Developmental Biology, 2022 Dynamicity and flexibility of the chromatin landscape are critical for most of the DNA-dependent processes to occur. This higher-order packaging of the eukaryotic genome into the chromatin is mediated by histones and associated non-histone proteins that ...
Sruthy Manuraj Rajam +4 more
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The Histone Chaperones SET/TAF‐1β and NPM1 Exhibit Conserved Functionality in Nucleosome Remodeling and Histone Eviction in a Cytochrome c‐Dependent Manner [PDF]
Advanced Science, 2023 Chromatin homeostasis mediates essential processes in eukaryotes, where histone chaperones have emerged as major regulatory factors during DNA replication, repair, and transcription.
Pedro Buzón +5 more
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Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry [PDF]
Nature Communications, 2022 Tousled-like kinase 2 (TLK2) phosphorylates ASF1 histone chaperones to promote nucleosome assembly in S phase. Here, the authors show that TLK2 targets ASF1 by simulating its client protein histone H3, exploiting a primordial protein interaction surface ...
Bertrand Simon +6 more
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Proteomic profiling of UV damage repair patches uncovers histone chaperones with central functions in chromatin repair [PDF]
Nature CommunicationsDNA damage compromises not only genome stability but also chromatin integrity, which plays a central role in controlling cell identity. Chromatin repair entails the deposition of new histones at sites of DNA damage.
Alexandre Plessier +5 more
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Histone chaperone-mediated nucleosome assembly process. [PDF]
PLoS ONE, 2015 A huge amount of information is stored in genomic DNA and this stored information resides inside the nucleus with the aid of chromosomal condensation factors.
Hsiu-Fang Fan +4 more
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Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone [PDF]
Nature Communications, 2019 ATAD2 AAA+ ATPases are a family of histone chaperones that regulate nucleosome density and chromatin dynamics. Here, authors find that the fission yeast ATAD2 homolog Abo1 deposits histone H3–H4 onto DNA in an ATP-hydrolysis-dependent manner, and present
Carol Cho +8 more
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Function of HP1BP3 as a linker histone is regulated by linker histone chaperones, NPM1 and TAF-I [PDF]
Epigenetics & ChromatinBackground Linker histones constitute a class of proteins that are responsible for the formation of higher-order chromatin structures. Core histones are integral components of nucleosome core particles (NCPs), whereas linker histones bind to linker DNA ...
Miharu Hisaoka +5 more
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Towards a mechanism for histone chaperones. [PDF]
Biochim Biophys Acta, 2013 Histone chaperones can be broadly defined as histone-binding proteins that influence chromatin dynamics in an ATP-independent manner. Their existence reflects the importance of chromatin homeostasis and the unique and unusual biochemistry of the histone proteins.
Elsässer SJ, D'Arcy S.
europepmc +5 more sources
The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution. [PDF]
Nucleic Acids Res, 2014 NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a ...
Bowman A +9 more
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Chromatin remodeling by HIRA and FAS2 restricts geminivirus pathogenesis in plants [PDF]
Virology JournalBackground Geminiviruses represent a significant threat to global agriculture due to the substantial crop loss they inflict worldwide. Histone chaperones, a highly conserved family of proteins primarily recognized for their roles in nucleosome assembly ...
Shirin Sultana +2 more
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