Histone Chaperones as Cardinal Players in Development [PDF]
Frontiers in Cell and Developmental Biology, 2022 Dynamicity and flexibility of the chromatin landscape are critical for most of the DNA-dependent processes to occur. This higher-order packaging of the eukaryotic genome into the chromatin is mediated by histones and associated non-histone proteins that ...
Sruthy Manuraj Rajam +4 more
doaj +4 more sources
Function of HP1BP3 as a linker histone is regulated by linker histone chaperones, NPM1 and TAF-I [PDF]
Epigenetics & ChromatinBackground Linker histones constitute a class of proteins that are responsible for the formation of higher-order chromatin structures. Core histones are integral components of nucleosome core particles (NCPs), whereas linker histones bind to linker DNA ...
Miharu Hisaoka +5 more
doaj +3 more sources
Histone variant H3.5 in testicular cell differentiation and its interactions with histone chaperones [PDF]
Scientific ReportsTesticular cell differentiation is a highly regulated process, essential for male reproductive health. The histone variant H3.5 is apparently a critical player in this intricate orchestra of cell types, but its regulation and function remains poorly ...
Patrick Philipp Weil +11 more
doaj +3 more sources
The Histone Chaperones SET/TAF‐1β and NPM1 Exhibit Conserved Functionality in Nucleosome Remodeling and Histone Eviction in a Cytochrome c‐Dependent Manner [PDF]
Advanced Science, 2023 Chromatin homeostasis mediates essential processes in eukaryotes, where histone chaperones have emerged as major regulatory factors during DNA replication, repair, and transcription.
Pedro Buzón +5 more
doaj +2 more sources
Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry [PDF]
Nature Communications, 2022 Tousled-like kinase 2 (TLK2) phosphorylates ASF1 histone chaperones to promote nucleosome assembly in S phase. Here, the authors show that TLK2 targets ASF1 by simulating its client protein histone H3, exploiting a primordial protein interaction surface ...
Bertrand Simon +6 more
doaj +2 more sources
Proteomic profiling of UV damage repair patches uncovers histone chaperones with central functions in chromatin repair [PDF]
Nature CommunicationsDNA damage compromises not only genome stability but also chromatin integrity, which plays a central role in controlling cell identity. Chromatin repair entails the deposition of new histones at sites of DNA damage.
Alexandre Plessier +5 more
doaj +3 more sources
Chromatin remodeling by HIRA and FAS2 restricts geminivirus pathogenesis in plants [PDF]
Virology JournalBackground Geminiviruses represent a significant threat to global agriculture due to the substantial crop loss they inflict worldwide. Histone chaperones, a highly conserved family of proteins primarily recognized for their roles in nucleosome assembly ...
Shirin Sultana +2 more
doaj +2 more sources
TSPY-like 2, Beyond the Histone Chaperone Role [PDF]
BiomoleculesChromatin is a dynamic cellular structure basically constituted by nucleosomes, which consist of a DNA sequence wrapped around an octameric histones core.
Emanuele Bonenti +3 more
doaj +2 more sources
ATAD2 mediates chromatin-bound histone chaperone turnover [PDF]
eLifeATAD2, a conserved protein which is predominantly expressed in embryonic stem (ES) cells and spermatogenic cells, emerges as a crucial regulator of chromatin plasticity. Our previous parallel studies conducted in both ES cells and S.
Ariadni Liakopoulou +13 more
doaj +2 more sources
The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells [PDF]
Molecular Cell, 2018 Ting-Hsiang Huang +2 more
exaly +2 more sources