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Histone variants in skeletal myogenesis [PDF]
Epigenetics, 2021 Histone variants regulate chromatin accessibility and gene transcription. Given their distinct properties and functions, histone varint substitutions allow for profound alteration of nucleosomal architecture and local chromatin landscape.
Nandini Karthik, Reshma Taneja
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The Role of MacroH2A Histone Variants in Cancer [PDF]
Cancers, 2021 The epigenome regulates gene expression and provides a molecular memory of cellular events. A growing body of evidence has highlighted the importance of epigenetic regulation in physiological tissue homeostasis and malignant transformation. Among epigenetic mechanisms, the replacement of replication-coupled histones with histone variants is the least ...
Chen-Jen Hsu +2 more
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Histone variants shape chromatin states in Arabidopsis [PDF]
eLife, 2023 How different intrinsic sequence variations and regulatory modifications of histones combine in nucleosomes remain unclear. To test the importance of histone variants in the organization of chromatin we investigated how histone variants and histone ...
Bhagyshree Jamge +8 more
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Histone Variants and Their Chaperones in Hematological Malignancies [PDF]
HemaSphere, 2023 Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins.
Ecem Kirkiz +3 more
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Histone variants at a glance. [PDF]
J Cell Sci, 2021 ABSTRACT Eukaryotic nucleosomes organize chromatin by wrapping 147 bp of DNA around a histone core particle comprising two molecules each of histone H2A, H2B, H3 and H4. The DNA entering and exiting the particle may be bound by the linker histone H1.
Talbert PB, Henikoff S.
europepmc +3 more sources
Advances in biological functions and mechanisms of histone variants in plants [PDF]
Frontiers in Genetics, 2023 Nucleosome is the basic subunit of chromatin, consisting of approximately 147bp DNA wrapped around a histone octamer, containing two copies of H2A, H2B, H3 and H4.
Xi Wu +4 more
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Histone variants and chromatin structure, update of advances [PDF]
Computational and Structural Biotechnology Journal, 2023 Histone proteins are highly conserved among all eukaryotes. They have two important functions in the cell: to package the genomic DNA and to regulate gene accessibility.
Vladyslava Sokolova +2 more
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Histone variants: key regulators of inflammation in cell dedifferentiation and transdifferentiation [PDF]
Frontiers in ImmunologyHistone variants are specialized isoforms of histone proteins that play crucial roles in regulating chromatin structure and function, influencing transcription, DNA repair, and cell cycle progression.
Manlio Vinciguerra, Desislava K. Tsoneva
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Contribution of histone variants to aneuploidy: a cancer perspective [PDF]
Frontiers in Genetics, 2023 Histone variants, which generally differ in few amino acid residues, can replace core histones (H1, H2A, H2B, and H3) to confer specific structural and functional features to regulate cellular functions.
Denise Ragusa, Paola Vagnarelli
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The Function of H2A Histone Variants and Their Roles in Diseases [PDF]
BiomoleculesEpigenetic regulation, which is characterized by reversible and heritable genetic alterations without changing DNA sequences, has recently been increasingly studied in diseases.
Xuemin Yin +4 more
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