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Histone Variants and Their Chaperones in Hematological Malignancies [PDF]
HemaSphere, 2023 Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins.
Ecem Kirkiz +3 more
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Contribution of histone variants to aneuploidy: a cancer perspective [PDF]
Frontiers in Genetics, 2023 Histone variants, which generally differ in few amino acid residues, can replace core histones (H1, H2A, H2B, and H3) to confer specific structural and functional features to regulate cellular functions.
Denise Ragusa, Paola Vagnarelli
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Histone variants and chromatin structure, update of advances [PDF]
Computational and Structural Biotechnology Journal, 2023 Histone proteins are highly conserved among all eukaryotes. They have two important functions in the cell: to package the genomic DNA and to regulate gene accessibility.
Vladyslava Sokolova +2 more
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Histone variants in skeletal myogenesis [PDF]
Epigenetics, 2021 Histone variants regulate chromatin accessibility and gene transcription. Given their distinct properties and functions, histone varint substitutions allow for profound alteration of nucleosomal architecture and local chromatin landscape.
Nandini Karthik, Reshma Taneja
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The Function of H2A Histone Variants and Their Roles in Diseases [PDF]
BiomoleculesEpigenetic regulation, which is characterized by reversible and heritable genetic alterations without changing DNA sequences, has recently been increasingly studied in diseases.
Xuemin Yin +4 more
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Histone variants shape chromatin states in Arabidopsis [PDF]
eLife, 2023 How different intrinsic sequence variations and regulatory modifications of histones combine in nucleosomes remain unclear. To test the importance of histone variants in the organization of chromatin we investigated how histone variants and histone ...
Bhagyshree Jamge +8 more
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Histone Variants: Guardians of Genome Integrity [PDF]
Cells, 2020 Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer.
Juliette Ferrand +2 more
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Advances in biological functions and mechanisms of histone variants in plants [PDF]
Frontiers in Genetics, 2023 Nucleosome is the basic subunit of chromatin, consisting of approximately 147bp DNA wrapped around a histone octamer, containing two copies of H2A, H2B, H3 and H4.
Xi Wu +4 more
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Histone variants: key regulators of inflammation in cell dedifferentiation and transdifferentiation [PDF]
Frontiers in ImmunologyHistone variants are specialized isoforms of histone proteins that play crucial roles in regulating chromatin structure and function, influencing transcription, DNA repair, and cell cycle progression.
Manlio Vinciguerra, Desislava K. Tsoneva
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Proteomic Analysis of Histone Variants and Their PTMs: Strategies and Pitfalls [PDF]
Proteomes, 2018 Epigenetic modifications contribute to the determination of cell fate and differentiation. The molecular mechanisms underlying histone variants and post-translational modifications (PTMs) have been studied in the contexts of development, differentiation,
Sara El Kennani +3 more
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