Quantitative Kinetic Analyses of Histone Turnover Using Imaging and Flow Cytometry
Bio-Protocol, 2020 Dynamic histone changes occur as a central part of chromatin regulation. Deposition of histone variants and post-translational modifications of histones are strongly associated with properties of chromatin status.
Hanae Sato, Robert Singer, John Greally
doaj +1 more source
Apicomplexa and Histone Variants: What’s New? [PDF]
, 2019 Plasmodium spp. and Toxoplasma gondii present a conserved nucleosome composition based on canonical H3 and variants, H4, canonical H2A and variants, and H2B.
Sergio Oscar Angel +5 more
core +1 more source
A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation
iScience, 2019 Summary: Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active regulatory regions associated with gene expression. Although the Tip60 complex is proposed to acetylate H2A.Z, functional studies suggest additional enzymes are involved.
Yolanda Colino-Sanguino +10 more
doaj +1 more source
Fine mapping of posttranslational modifications of the linker histone H1 from Drosophila melanogaster. [PDF]
, 2008 The linker histone H1 binds to the DNA in between adjacent nucleosomes and contributes to chromatin organization and transcriptional control. It is known that H1 carries diverse posttranslational modifications (PTMs), including phosphorylation, lysine ...
Villar-Garea, Ana +3 more
core +2 more sources
HistoneDB 2.0: a histone database with variants—an integrated resource to explore histones and their variants [PDF]
Database, 2016 Compaction of DNA into chromatin is a characteristic feature of eukaryotic organisms. The core (H2A, H2B, H3, H4) and linker (H1) histone proteins are responsible for this compaction through the formation of nucleosomes and higher order chromatin aggregates.
Eli J. Draizen +5 more
openaire +3 more sources
Frontiers in Immunology, 2022 In teleost fish, the nucleotide polymorphisms of histone H2A significantly affect the resistance or susceptibility of zebrafish to Edwardsiella piscicida infection.
Yuan Yuan Yang +10 more
doaj +1 more source
Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]
, 2011 Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Jose M. Arteaga-Salas +23 more
core +1 more source
Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
Nature Communications, 2017 Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers.
Fátima Valdés-Mora +18 more
doaj +1 more source
The evolution and functional divergence of the histone H2B family in plants.
PLoS Genetics, 2020 Chromatin regulation of eukaryotic genomes depends on the formation of nucleosome complexes between histone proteins and DNA. Histone variants, which are diversified by sequence or expression pattern, can profoundly alter chromatin properties.
Danhua Jiang +7 more
doaj +1 more source
Phylogenomics of unusual histone H2A Variants in Bdelloid rotifers. [PDF]
PLoS Genetics, 2009 Rotifers of Class Bdelloidea are remarkable in having evolved for millions of years, apparently without males and meiosis. In addition, they are unusually resistant to desiccation and ionizing radiation and are able to repair hundreds of radiation ...
Karine Van Doninck +7 more
doaj +1 more source