Results 21 to 30 of about 836,867 (274)
The Role of MacroH2A Histone Variants in Cancer. [PDF]
Cancers (Basel), 2021 The epigenome regulates gene expression and provides a molecular memory of cellular events. A growing body of evidence has highlighted the importance of epigenetic regulation in physiological tissue homeostasis and malignant transformation. Among epigenetic mechanisms, the replacement of replication-coupled histones with histone variants is the least ...
Hsu CJ, Meers O, Buschbeck M, Heidel FH.
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Histone Variants and Epigenetics [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Histones package and compact DNA by assembling into nucleosome core particles. Most histones are synthesized at S phase for rapid deposition behind replication forks. In addition, the replacement of histones deposited during S phase by variants that can be deposited independently of replication provide the most fundamental level of chromatin ...
Steven, Henikoff, M Mitchell, Smith
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DDM1 Maintains Heterochromatin by Regulating Histone Variants. [PDF]
Int J Mol SciChromatin remodeling factors efficiently and precisely establish, maintain, regulate, and distinguish between chromatin states in eukaryotes. DECREASE in DNA METHYLATION 1 (DDM1) is an important heterochromatin remodeling factor in plants that is ...
Sun Y +5 more
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Beyond the Usual Suspects: Examining the Role of Understudied Histone Variants in Breast Cancer. [PDF]
Int J Mol SciThe incorporation of histone variants has structural ramifications on nucleosome dynamics and stability. Due to their unique sequences, histone variants can alter histone–histone or histone–DNA interactions, impacting the folding of DNA ...
Dhahri H +3 more
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Epigenetic Regulation of Myogenesis: Focus on the Histone Variants. [PDF]
Int J Mol Sci, 2021 International audienceSkeletal muscle development and regeneration rely on the successive activation of specific transcription factors that engage cellular fate, promote commitment, and drive differentiation.
Esteves de Lima J, Relaix F.
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Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
Cells, 2020 The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law +2 more
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Histone variants in archaea - an undiscovered country. [PDF]
, 2022 Exchanging core histones in the nucleosome for paralogous variants can have important functional ramifications. Many of these variants, and their physiological roles, have been characterized in exquisite detail in model eukaryotes, including humans.
Stevens, Kathryn M +3 more
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Plant Histone HTB (H2B) Variants in Regulating Chromatin Structure and Function
Plants, 2020 Besides chemical modification of histone proteins, chromatin dynamics can be modulated by histone variants. Most organisms possess multiple genes encoding for core histone proteins, which are highly similar in amino acid sequence.
Janardan Khadka +2 more
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Journal of Integrative Neuroscience, 2023 Neurodevelopment is a highly regulated process that relies on the precise regulation of gene expression. Numerous epigenetic mechanisms contribute and cooperate to ensure the proper execution of developmental gene expression programs.
Karanveer S Johal +2 more
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Epigenetic Regulation by Histone Methylation and Histone Variants [PDF]
Molecular Endocrinology, 2005 Epigenetics is the study of heritable changes in gene expression that are not mediated at the DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include DNA methylation and chromatin/histone modifications. With the identification of key histone-modifying enzymes, the biological functions of many histone posttranslational ...
Peter, Cheung, Priscilla, Lau
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