Results 21 to 30 of about 93,929 (281)

DDM1 Maintains Heterochromatin by Regulating Histone Variants. [PDF]

Int J Mol Sci
Chromatin remodeling factors efficiently and precisely establish, maintain, regulate, and distinguish between chromatin states in eukaryotes. DECREASE in DNA METHYLATION 1 (DDM1) is an important heterochromatin remodeling factor in plants that is ...
Sun Y, Xie Q, Chu H, Lv B, Xie L, Zhang Q.   +5 more
europepmc   +2 more sources

Epigenetic Regulation of Myogenesis: Focus on the Histone Variants. [PDF]

Int J Mol Sci, 2021
International audienceSkeletal muscle development and regeneration rely on the successive activation of specific transcription factors that engage cellular fate, promote commitment, and drive differentiation.
Esteves de Lima J, Relaix F.
europepmc   +2 more sources

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

Cells, 2020
The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law, Fatima Valdes-Mora, David Gallego-Ortega   +2 more
doaj   +1 more source

Plant Histone HTB (H2B) Variants in Regulating Chromatin Structure and Function

Plants, 2020
Besides chemical modification of histone proteins, chromatin dynamics can be modulated by histone variants. Most organisms possess multiple genes encoding for core histone proteins, which are highly similar in amino acid sequence.
Janardan Khadka, Anat Pesok, Gideon Grafi   +2 more
doaj   +1 more source

Histone Variants and Their Chaperones: An Emerging Epigenetic Mechanism in Neurodevelopment and Neurodevelopmental Disorders

Journal of Integrative Neuroscience, 2023
Neurodevelopment is a highly regulated process that relies on the precise regulation of gene expression. Numerous epigenetic mechanisms contribute and cooperate to ensure the proper execution of developmental gene expression programs.
Karanveer S Johal, Manjinder S Cheema, Gilda Stefanelli   +2 more
doaj   +1 more source

Quantitative Kinetic Analyses of Histone Turnover Using Imaging and Flow Cytometry

Bio-Protocol, 2020
Dynamic histone changes occur as a central part of chromatin regulation. Deposition of histone variants and post-translational modifications of histones are strongly associated with properties of chromatin status.
Hanae Sato, Robert Singer, John Greally
doaj   +1 more source

Epigenetic Regulation by Histone Methylation and Histone Variants [PDF]

Molecular Endocrinology, 2005
Epigenetics is the study of heritable changes in gene expression that are not mediated at the DNA sequence level. Molecular mechanisms that mediate epigenetic regulation include DNA methylation and chromatin/histone modifications. With the identification of key histone-modifying enzymes, the biological functions of many histone posttranslational ...
Peter, Cheung, Priscilla, Lau
openaire   +2 more sources

A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation

iScience, 2019
Summary: Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active regulatory regions associated with gene expression. Although the Tip60 complex is proposed to acetylate H2A.Z, functional studies suggest additional enzymes are involved.
Yolanda Colino-Sanguino, Evan M. Cornett, David Moulder, Grady C. Smith, Joel Hrit, Eric Cordeiro-Spinetti, Robert M. Vaughan, Krzysztof Krajewski, Scott B. Rothbart, Susan J. Clark, Fátima Valdés-Mora   +10 more
doaj   +1 more source

Immunoprotective Effects of Two Histone H2A Variants in the Grass Carp Against Flavobacterium columnare Infection

Frontiers in Immunology, 2022
In teleost fish, the nucleotide polymorphisms of histone H2A significantly affect the resistance or susceptibility of zebrafish to Edwardsiella piscicida infection.
Yuan Yuan Yang, Yuan Yuan Yang, Si Yao Zheng, Si Yao Zheng, Hong Fang, Hong Fang, Xiao Man Wu, Jie Zhang, Ming Xian Chang, Ming Xian Chang, Ming Xian Chang   +10 more
doaj   +1 more source

Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]

, 2011
Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Jose M. Arteaga-Salas, Edith Mentele, Ralph A. W. Rupp, Arteaga-Salas, Jose M., Tobias D Schneider, Schneider, Tobias D., Tobias D. Schneider, Rupp, Ralph A. W., Jose M Arteaga-Salas, Ralph A W Rupp, Imhof, Axel, Nicetto, Dario, Dario Nicetto, Robert David, Axel Imhof, Mentele, Edith, David, Robert   +16 more
core   +1 more source