Results 1 to 10 of about 198,744 (258)

Histone modifications across cancers: mechanisms, therapy and clinical translation [PDF]

Molecular Cancer
Cancer continues to be a major cause of death across the globe, and epigenetic dysregulation, including histone modifications, has been recognized as a major hallmark of cancer development, heterogeneity, and drug resistance.
Pengde Lu, Yau-Tuen Chan, Chun-Fung Kwok, Qiucheng Li, Zhuofeng Jiang, Lin Xu, Zixin Feng, Hongchao Yuan, Jiaqi Zou, Yunqing Xun, Tung-Leong Fong, Chi-Ming Che, Ning Wang   +12 more
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Histone modifications: Unveiling the epigenetic enigma of degenerative skeletal diseases [PDF]

Journal of Orthopaedic Translation
Degenerative skeletal diseases, including osteoporosis, osteoarthritis, and intervertebral disc degeneration, are prevalent age-related conditions characterized by progressive tissue degeneration and functional decline. Histone modifications are covalent
Yao Zhang, Jiale Wang, Di Hua, Chunyang Fan, Wei He, Yongkang Deng, Maoting Tang, Dechun Geng, Xiexing Wu, Haiqing Mao   +9 more
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Editorial: Histone modifications in cancer [PDF]

Frontiers in Pharmacology
Jiaqian Luo, Sizhi P. Gao
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Histone modifications in neurodifferentiation of embryonic stem cells

Heliyon, 2022
Post-translational modifications of histone proteins regulate a long cascade of downstream cellular activities, including transcription and replication.
Min Huang, Xiaoxiao Xiao, Guanxu Ji, Qiang Wu   +3 more
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Histone variants shape chromatin states in Arabidopsis

eLife, 2023
How different intrinsic sequence variations and regulatory modifications of histones combine in nucleosomes remain unclear. To test the importance of histone variants in the organization of chromatin we investigated how histone variants and histone ...
Bhagyshree Jamge, Zdravko J Lorković, Elin Axelsson, Akihisa Osakabe, Vikas Shukla, Ramesh Yelagandula, Svetlana Akimcheva, Annika Luisa Kuehn, Frédéric Berger   +8 more
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Histone Modifications and Other Facets of Epigenetic Regulation in Trypanosomatids: Leaving Their Mark

mBio, 2020
Histone posttranslational modifications (PTMs) modulate several eukaryotic cellular processes, including transcription, replication, and repair. Vast arrays of modifications have been identified in conventional eukaryotes over the last 20 to 25 years ...
Swati Saha
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Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification

Cell Death and Disease, 2023
Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated immune responses and multiple organ dysfunction. The imbalance between hyperinflammation and immunosuppression is a crucial feature of sepsis immunity.
Dan Wu, Yuxin Shi, Hao Zhang, Changhong Miao   +3 more
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Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease

Frontiers in Pharmacology, 2021
Chronic liver disease (CLD) represents a global health problem, accounting for the heavy burden of disability and increased health care utilization. Epigenome alterations play an important role in the occurrence and progression of CLD.
Qiuyu Cai, Qiuyu Cai, Can Gan, Can Gan, Chengwei Tang, Chengwei Tang, Hao Wu, Jinhang Gao, Jinhang Gao   +8 more
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Modeling exon expression using histone modifications. [PDF]

PLoS ONE, 2013
Histones undergo numerous covalent modifications that play important roles in regulating gene expression. Previous investigations have focused on the effects of histone modifications on gene promoters, whereas efforts to unravel their effects on ...
Shijia Zhu, Guohua Wang, Bo Liu, Yadong Wang   +3 more
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The function of histone methylation and acetylation regulators in GBM pathophysiology

Frontiers in Oncology, 2023
Glioblastoma (GBM) is the most common and lethal primary brain malignancy and is characterized by a high degree of intra and intertumor cellular heterogeneity, a starkly immunosuppressive tumor microenvironment, and nearly universal recurrence.
Colin McCornack, Timothy Woodiwiss, Timothy Woodiwiss, Angela Hardi, Hiroko Yano, Hiroko Yano, Albert H. Kim, Albert H. Kim   +7 more
doaj   +1 more source