Results 1 to 10 of about 301,141 (302)

Editorial: Histone modifications in cancer [PDF]

Frontiers in Pharmacology
Jiaqian Luo, Sizhi P. Gao
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Histone Modifications and the Maintenance of Telomere Integrity

Cells, 2019
Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, play an integral role in protecting linear DNA from degradation. Dysregulation of telomeres can result in genomic instability and has been implicated in increased rates of ...
Meagan Jezek, Erin M. Green
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Reprogramming histone modification patterns to coordinate gene expression in early zebrafish embryos

BMC Genomics, 2019
Background Multicellular organisms require precise gene regulation during ontogeny, and epigenetic modifications, such as DNA methylation and histone modification, facilitate this precise regulation.
Wei Zhu, Xiaocui Xu, Xinxin Wang, Jiang Liu   +3 more
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Epigenetic modifications involving ncRNAs in digestive system cancers: focus on histone modification

Clinical Epigenetics
In recent years, epigenetic modifications have been strongly linked to tumor development, with histone modifications representing a key epigenetic mechanism. In addition, non-coding RNAs (ncRNAs) play a critical role in regulating cancer-related pathways.
Xiaodi Yin, Jingyi Li, Jiahui Zhao, Weihan Zheng, Aohua Zhang, Jun Ma   +5 more
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Protein kinase C coordinates histone H3 phosphorylation and acetylation

eLife, 2015
The re-assembly of chromatin following DNA replication is a critical event in the maintenance of genome integrity. Histone H3 acetylation at K56 and phosphorylation at T45 are two important chromatin modifications that accompany chromatin assembly.
Zoulfia Darieva, Aaron Webber, Stacey Warwood, Andrew D Sharrocks   +3 more
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Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice

Scientific Reports
During the development of multicellular organisms and cell differentiation, the chromatin structure in the cell nucleus undergoes extensive changes, and the nucleosome structure is formed by a combination of various histone variants.
Takayuki Kawaguchi, Michihiro Hashimoto, Reiko Nakagawa, Ryunosuke Minami, Masahito Ikawa, Jun-ichi Nakayama, Jun Ueda   +6 more
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Post-translational histone modifications associated with the development of metabolic dysfunction-associated fatty liver disease. Part 1. General provisions

Gastroenterologìa
Based on the analysis of literary sources of PubMed, MedLine, The Cochrane Library, EMBASE database, the authors of the article give general provisions regarding post-translational modifications of histones (small proteins with a molecular weight of 10 ...
O.E. Abaturov, A.O. Nikulina
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The BAF complex enhances transcription through interaction with H3K56ac in the histone globular domain

Nature Communications
Histone post-translational modifications play pivotal roles in eukaryotic gene expression. To date, most studies have focused on modifications in unstructured histone N-terminal tail domains and their binding proteins. However, transcriptional regulation
Kwangbeom Hyun, Jihye Ahn, Hyoungmin Kim, Jihyun Kim, Yong-In Kim, Hee-Sung Park, Robert G. Roeder, J. Eugene Lee, Jaehoon Kim   +8 more
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Role of histone post-translational modifications in atherosclerosis and the therapeutic potential of targeting epigenetic modifiers

Frontiers in Cell and Developmental Biology
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, with atherosclerosis being the primary pathological substrate underlying most CVD.
Lili Wu, Wei Li, Wei Ye
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An RNAi-based platform for spatiotemporal control of histone gene expression during animal development

Epigenetics & Chromatin
Background Mutational analysis of histones provides an important means of studying the function of histone post-translational modifications (PTMs) in epigenetic gene regulation.
Oscar M. Arroyo, Mary P. Leatham-Jensen, Daniel J. McKay   +2 more
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