Results 1 to 10 of about 2,172,961 (295)
The roles of histone modifications in tumorigenesis and associated inhibitors in cancer therapy
Journal of the National Cancer Center, 2022 Histone modifications are key factors in chromatin packaging, and are responsible for gene regulation during cell fate determination and development. Abnormal alterations in histone modifications potentially affect the stability of the genome and disrupt
Yunkai Yang, Min Zhang, Yan Wang
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Histone Modifications and Cancer [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In this article, we review many of the key and newly identified histone modifications known to be deregulated in cancer ...
James E, Audia, Robert M, Campbell
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The role of histone modifications: from neurodevelopment to neurodiseases
Signal Transduction and Targeted Therapy, 2022 Epigenetic regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and microRNA expression, play critical roles in cell differentiation and organ development through spatial and temporal gene regulation. Neurogenesis
Jisu Park +3 more
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Histone Modifications in Alzheimer’s Disease
Genes, 2023 Since Late-onset Alzheimer’s disease (LOAD) derives from a combination of genetic variants and environmental factors, epigenetic modifications have been predicted to play a role in the etiopathology of LOAD.
Dalileia A Santana +2 more
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Readers of histone modifications [PDF]
Cell Research, 2011 Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks. Accumulating evidence suggests that the key function of histone modifications is to signal for recruitment or activity of downstream effectors. Here, we discuss the latest discovery of
Jerry L Workman +2 more
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Histone Modifications as an Intersection Between Diet and Longevity
Frontiers in Genetics, 2019 Histone modifications are key epigenetic regulators that control chromatin structure and gene transcription, thereby impacting on various important cellular phenotypes.
Diego Molina-Serrano +4 more
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Histone modifications and their role in epigenetics of atopy and allergic diseases
Allergy, Asthma & Clinical Immunology, 2018 This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development.
Bilal Alaskhar Alhamwe +11 more
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Histone onco-modifications [PDF]
Oncogene, 2011 Post-translational modification of histones provides an important regulatory platform for processes such as gene expression, DNA replication and repair, chromosome condensation and segregation and apoptosis. Disruption of these processes has been linked to the multistep process of carcinogenesis.
Bertrand Joseph, Joseph B
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Cell Reports, 2019 Summary: Genomic DNA is framed by additional layers of information, referred to as the epigenome. Epigenomic marks such as DNA methylation, histone modifications, and histone variants are concentrated on specific genomic sites, where they can both ...
Célia Jeronimo +2 more
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Histone modifications: Unveiling the epigenetic enigma of degenerative skeletal diseases [PDF]
Journal of Orthopaedic TranslationDegenerative skeletal diseases, including osteoporosis, osteoarthritis, and intervertebral disc degeneration, are prevalent age-related conditions characterized by progressive tissue degeneration and functional decline. Histone modifications are covalent
Yao Zhang +9 more
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