Results 41 to 50 of about 2,172,961 (295)
Classification of Promoters Based on the Combination of Core Promoter Elements Exhibits Different Histone Modification Patterns. [PDF]
PLoS ONE, 2016 Four different histones (H2A, H2B, H3, and H4; two subunits each) constitute a histone octamer, around which DNA wraps to form histone-DNA complexes called nucleosomes.
Yayoi Natsume-Kitatani +1 more
doaj +1 more source
Molecules and Cells, 2019 Eukaryotic chromosomes contain compartments of various functions, which are marked by and enriched with specific histone modifications. However, the molecular mechanisms by which these histone marks function in chromosome compartmentalization are poorly ...
Liang Wang +14 more
semanticscholar +1 more source
Histones and histone modifications in protozoan parasites
Cellular Microbiology, 2006 Protozoan parasites are early branching eukaryotes causing significant morbidity and mortality in humans and livestock. Single-celled parasites have evolved complex life cycles, which may involve multiple host organisms, and strategies to evade host immune responses.
William J, Sullivan +2 more
openaire +2 more sources
Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases
Signal Transduction and Targeted TherapyHistone post-translational modifications (HPTMs), as one of the core mechanisms of epigenetic regulation, are garnering increasing attention due to their close association with the onset and progression of diseases and their potential as targeted ...
Weiyi Yao, Xinting Hu, Xin Wang
semanticscholar +1 more source
Resetting histone modifications during human parental-to-zygotic transition
Science, 2019 Epigenetics of human embryonic development Substantial epigenetic reprogramming occurs in mammalian early development. Xia et al. investigated the reprogramming dynamics of three key histone modifications in human early embryonic development.
Weikun Xia +23 more
semanticscholar +1 more source
Histone modifications during the life cycle of the brown alga Ectocarpus
Genome Biology, 2021 Background Brown algae evolved complex multicellularity independently of the animal and land plant lineages and are the third most developmentally complex phylogenetic group on the planet.
Simon Bourdareau +7 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Unraveling the complexity of the histone code: implications for gene regulation and disease
Genome BiologyHistone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical and variant histones generate a ...
Kiera L. Malone +13 more
doaj +1 more source
ChIP-seq profiling of H3K4me3 and H3K27me3 in an invasive insect, Bactroceradorsalis
Frontiers in Genetics, 2023 Introduction: While it has been suggested that histone modifications can facilitate animal responses to rapidly changing environments, few studies have profiled whole-genome histone modification patterns in invasive species, leaving the regulatory ...
Yan Zhao +3 more
doaj +1 more source
Histone Modifications at Human Enhancers Reflect Global Cell Type-Specific Gene Expression
Nature, 2009 The human body is composed of diverse cell types with distinct functions. Although it is known that lineage specification depends on cell-specific gene expression, which in turn is driven by promoters, enhancers, insulators and other cis-regulatory DNA ...
Nathaniel D. Heintzman +20 more
semanticscholar +1 more source