Results 21 to 30 of about 301,141 (302)
Modeling exon expression using histone modifications. [PDF]
PLoS ONE, 2013 Histones undergo numerous covalent modifications that play important roles in regulating gene expression. Previous investigations have focused on the effects of histone modifications on gene promoters, whereas efforts to unravel their effects on ...
Shijia Zhu +3 more
doaj +1 more source
The roles of histone modifications in tumorigenesis and associated inhibitors in cancer therapy
Journal of the National Cancer Center, 2022 Histone modifications are key factors in chromatin packaging, and are responsible for gene regulation during cell fate determination and development. Abnormal alterations in histone modifications potentially affect the stability of the genome and disrupt
Yunkai Yang, Min Zhang, Yan Wang
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Co-regulation of histone-modifying enzymes in cancer. [PDF]
PLoS ONE, 2011 Cancer is characterized by aberrant patterns of expression of multiple genes. These major shifts in gene expression are believed to be due to not only genetic but also epigenetic changes.
Abul B M M K Islam +4 more
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The function of histone methylation and acetylation regulators in GBM pathophysiology
Frontiers in Oncology, 2023 Glioblastoma (GBM) is the most common and lethal primary brain malignancy and is characterized by a high degree of intra and intertumor cellular heterogeneity, a starkly immunosuppressive tumor microenvironment, and nearly universal recurrence.
Colin McCornack +7 more
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The inheritance of histone modifications depends upon the location in the chromosome in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 Histone modifications are important epigenetic features of chromatin that must be replicated faithfully. However, the molecular mechanisms required to duplicate and maintain histone modification patterns in chromatin remain to be determined.
Hiroshi Masumoto +4 more
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GoPeaks: histone modification peak calling for CUT&Tag
Genome Biology, 2022 Genome-wide mapping of histone modifications is critical to understanding transcriptional regulation. CUT&Tag is a new method for profiling histone modifications, offering improved sensitivity and decreased cost compared with ChIP-seq.
William M. Yashar +8 more
doaj +1 more source
Combinatorial Pattern of Histone Modifications in Exon Skipping Event
Frontiers in Genetics, 2019 Histone modifications are associated with alternative splicing. It has been suggested that histone modifications act in combinational patterns in gene expression regulation.
Wei Chen +4 more
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Reciprocal intronic and exonic histone modification regions in humans. [PDF]
, 2010 While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine +3 more
core +2 more sources
SnapShot: Histone Modifications
Cell, 2014 Histone proteins are decorated by a variety of protein posttranslational modifications called histone marks that modulate chromatin structure and function, contributing to the cellular gene expression program. This SnapShot summarizes the reported human, mouse, and rat histone marks, including recently identified lysine acylation marks.
Huang, He +4 more
openaire +2 more sources
Histone Modifications and Cancer [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In this article, we review many of the key and newly identified histone modifications known to be deregulated in cancer ...
James E, Audia, Robert M, Campbell
openaire +2 more sources