Results 11 to 20 of about 301,141 (302)
Histone modifications: Unveiling the epigenetic enigma of degenerative skeletal diseases [PDF]
Journal of Orthopaedic TranslationDegenerative skeletal diseases, including osteoporosis, osteoarthritis, and intervertebral disc degeneration, are prevalent age-related conditions characterized by progressive tissue degeneration and functional decline. Histone modifications are covalent
Yao Zhang +9 more
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Epigenetic regulation of histone modifications in glioblastoma: recent advances and therapeutic insights [PDF]
Biomarker ResearchGlioblastoma (GBM) is the most common primary malignant brain tumor, characterized by its aggressive behavior, limited treatment options, and poor prognosis. Despite advances in surgery, radiotherapy, and chemotherapy, the median survival of GBM patients
Li Zhang +6 more
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Modeling the dynamics of bivalent histone modifications [PDF]
, 2013 Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the ...
Girvan, Michelle +4 more
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Histone modifications in neurodifferentiation of embryonic stem cells
Heliyon, 2022 Post-translational modifications of histone proteins regulate a long cascade of downstream cellular activities, including transcription and replication.
Min Huang +3 more
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Histone variants shape chromatin states in Arabidopsis
eLife, 2023 How different intrinsic sequence variations and regulatory modifications of histones combine in nucleosomes remain unclear. To test the importance of histone variants in the organization of chromatin we investigated how histone variants and histone ...
Bhagyshree Jamge +8 more
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Histones and histone modifications [PDF]
Current Biology, 2004 Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Peterson, Craig L, Laniel, Marc-André
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Histone onco-modifications [PDF]
Oncogene, 2011 Post-translational modification of histones provides an important regulatory platform for processes such as gene expression, DNA replication and repair, chromosome condensation and segregation and apoptosis. Disruption of these processes has been linked to the multistep process of carcinogenesis.
J, Füllgrabe, E, Kavanagh, B, Joseph
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mBio, 2020 Histone posttranslational modifications (PTMs) modulate several eukaryotic cellular processes, including transcription, replication, and repair. Vast arrays of modifications have been identified in conventional eukaryotes over the last 20 to 25 years ...
Swati Saha
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Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification
Cell Death and Disease, 2023 Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated immune responses and multiple organ dysfunction. The imbalance between hyperinflammation and immunosuppression is a crucial feature of sepsis immunity.
Dan Wu +3 more
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Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
Frontiers in Pharmacology, 2021 Chronic liver disease (CLD) represents a global health problem, accounting for the heavy burden of disability and increased health care utilization. Epigenome alterations play an important role in the occurrence and progression of CLD.
Qiuyu Cai +8 more
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