Results 11 to 20 of about 198,744 (258)
Epigenetic modifications of histones in cancer [PDF]
Genome Biology, 2019 The epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers.
Zibo Zhao, Ali Shilatifard
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Histones and histone modifications [PDF]
Current Biology, 2004 Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Peterson, Craig L, Laniel, Marc-André
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Histone Modifications and Cancer [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In this article, we review many of the key and newly identified histone modifications known to be deregulated in cancer ...
James E, Audia, Robert M, Campbell
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Co-regulation of histone-modifying enzymes in cancer. [PDF]
PLoS ONE, 2011 Cancer is characterized by aberrant patterns of expression of multiple genes. These major shifts in gene expression are believed to be due to not only genetic but also epigenetic changes.
Abul B M M K Islam +4 more
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The roles of histone modifications in tumorigenesis and associated inhibitors in cancer therapy
Journal of the National Cancer Center, 2022 Histone modifications are key factors in chromatin packaging, and are responsible for gene regulation during cell fate determination and development. Abnormal alterations in histone modifications potentially affect the stability of the genome and disrupt
Yunkai Yang, Min Zhang, Yan Wang
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The inheritance of histone modifications depends upon the location in the chromosome in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2011 Histone modifications are important epigenetic features of chromatin that must be replicated faithfully. However, the molecular mechanisms required to duplicate and maintain histone modification patterns in chromatin remain to be determined.
Hiroshi Masumoto +4 more
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GoPeaks: histone modification peak calling for CUT&Tag
Genome Biology, 2022 Genome-wide mapping of histone modifications is critical to understanding transcriptional regulation. CUT&Tag is a new method for profiling histone modifications, offering improved sensitivity and decreased cost compared with ChIP-seq.
William M. Yashar +8 more
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Combinatorial Pattern of Histone Modifications in Exon Skipping Event
Frontiers in Genetics, 2019 Histone modifications are associated with alternative splicing. It has been suggested that histone modifications act in combinational patterns in gene expression regulation.
Wei Chen +4 more
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Histone modifications and their role in epigenetics of atopy and allergic diseases
Allergy, Asthma & Clinical Immunology, 2018 This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the development of allergic diseases, including the immune mechanisms underlying this development.
Bilal Alaskhar Alhamwe +11 more
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The Histone Modifications of Neuronal Plasticity [PDF]
Neural Plasticity, 2021 Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation, and ubiquitination, which change the three-dimensional structure of chromosomes and affect gene ...
Huixia Geng +3 more
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