Results 11 to 20 of about 93,929 (281)
Histone Variants: Guardians of Genome Integrity [PDF]
Cells, 2020 Chromatin integrity is key for cell homeostasis and for preventing pathological development. Alterations in core chromatin components, histone proteins, recently came into the spotlight through the discovery of their driving role in cancer.
Juliette Ferrand +2 more
doaj +4 more sources
Histone Variants in Metazoan Development [PDF]
Developmental Cell, 2010 Embryonic development is regulated by both genetic and epigenetic mechanisms, with nearly all DNA-templated processes influenced by chromatin architecture. Sequence variations in histone proteins, core components of chromatin, provide a means to generate diversity in the chromatin structure, resulting in distinct and profound biological outcomes in the
Banaszynski, Laura A. +2 more
openaire +3 more sources
Histone variants and cellular plasticity [PDF]
Trends in Genetics, 2015 The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular signals and the DNA is the chromatin, a dynamic nucleoprotein complex that helps to mediate gene regulation.
Catherine Dulac
exaly +5 more sources
Proteomic Analysis of Histone Variants and Their PTMs: Strategies and Pitfalls [PDF]
Proteomes, 2018 Epigenetic modifications contribute to the determination of cell fate and differentiation. The molecular mechanisms underlying histone variants and post-translational modifications (PTMs) have been studied in the contexts of development, differentiation,
Sara El Kennani +3 more
doaj +2 more sources
Phylogenomics of unusual histone H2A Variants in Bdelloid rotifers. [PDF]
PLoS Genetics, 2009 Rotifers of Class Bdelloidea are remarkable in having evolved for millions of years, apparently without males and meiosis. In addition, they are unusually resistant to desiccation and ionizing radiation and are able to repair hundreds of radiation ...
Karine Van Doninck +7 more
doaj +3 more sources
Casting histone variants during mammalian reproduction. [PDF]
Chromosoma, 2023 International audienceDuring mammalian reproduction, germ cell chromatin packaging is key to prepare parental genomes for fertilization and to initiate embryonic development.
Karam G, Molaro A.
europepmc +2 more sources
Histone variants in archaea [PDF]
, 2022 Eukaryotic histone variants are involved in a wide range of processes and play a key role in altering nucleosome dynamics to shape the architecture of chromatin. The importance of individual variants has been studied extensively in many eukaryotes. In comparison, we know relatively little about histones in archaea.
Stevens, Kathryn
openaire +3 more sources
Visualizing the dynamics of histone variants in the S-phase nucleus [PDF]
Genome Biology, 2018 Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus remain poorly characterized.
Stella Maxouri +2 more
doaj +2 more sources
The roles of histone variants in fine-tuning chromatin organization and function [PDF]
Nature Reviews Molecular Cell Biology, 2020 Sara Martire +2 more
exaly +2 more sources
Histone Variants and Epigenetics [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Histones package and compact DNA by assembling into nucleosome core particles. Most histones are synthesized at S phase for rapid deposition behind replication forks. In addition, the replacement of histones deposited during S phase by variants that can be deposited independently of replication provide the most fundamental level of chromatin ...
Steven, Henikoff, M Mitchell, Smith
openaire +2 more sources