Results 11 to 20 of about 33,260 (245)

Histone chaperone networks shaping chromatin function [PDF]

Nature Reviews Molecular Cell Biology, 2017
The association of histones with specific chaperone complexes is important for their folding, oligomerization, post-translational modification, nuclear import, stability, assembly and genomic localization. In this way, the chaperoning of soluble histones is a key determinant of histone availability and fate, which affects all chromosomal processes ...
Hammond, Colin, Strømme, Caroline Bianchi, Huang, Hongda, Patel, Dinshaw J, Groth, Anja   +4 more
openaire   +5 more sources

DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network [PDF]

Molecular Cell, 2021
From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is unclear.
Hammond, Colin M., Bao, Hongyu, Hendriks, Ivo A., Carraro, Massimo, García-Nieto, Alberto, Liu, Yanhong, Reverón-Gómez, Nazaret, Spanos, Christos, Chen, Liu, Rappsilber, Juri, Nielsen, Michael L., Patel, Dinshaw J., Huang, Hongda, Groth, Anja   +13 more
openaire   +7 more sources

Histone Chaperones: Modulators of Chromatin Marks [PDF]

Molecular Cell, 2011
The many factors that control chromatin biology play key roles in essential nuclear functions like transcription, DNA damage response and repair, recombination, and replication and are critical for proper cell-cycle progression, stem cell renewal, differentiation, and development. These players belong to four broad classes: histone modifiers, chromatin
Avvakumov, Nikita, Nourani, Amine, Côté, Jacques   +2 more
openaire   +4 more sources

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone [PDF]

eLife, 2019
We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface.
Abhilash Padavannil, Prithwijit Sarkar, Seung Joong Kim, Tolga Cagatay, Jenny Jiou, Chad A Brautigam, Diana R Tomchick, Andrej Sali, Sheena D'Arcy, Yuh Min Chook   +9 more
doaj   +3 more sources

Histone variant H3.5 in testicular cell differentiation and its interactions with histone chaperones [PDF]

Scientific Reports
Testicular cell differentiation is a highly regulated process, essential for male reproductive health. The histone variant H3.5 is apparently a critical player in this intricate orchestra of cell types, but its regulation and function remains poorly ...
Patrick Philipp Weil, Anton Pembaur, Beatrice Wirth, Eda Oetjen, Hannes Büsscher, Klemens Zirngibl, Malte Czarnetzki, Stella Braun, Jann-Frederik Cremers, Daniel Gödde, Stephan Degener, Jan Postberg   +11 more
doaj   +2 more sources

Histone chaperones, histone acetylation, and the fluidity of the chromogenome. [PDF]

J Cell Physiol, 2010
AbstractThe “chromogenome” is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post‐translational acetylation of histones, and modulation of the chromogenome.
Hansen JC, Nyborg JK, Luger K, Stargell LA.   +3 more
europepmc   +4 more sources

TSPY-like 2, Beyond the Histone Chaperone Role [PDF]

Biomolecules
Chromatin is a dynamic cellular structure basically constituted by nucleosomes, which consist of a DNA sequence wrapped around an octameric histones core.
Emanuele Bonenti, Miriana Cardano, Giacomo Buscemi, Laura Zannini   +3 more
doaj   +2 more sources

ATAD2 mediates chromatin-bound histone chaperone turnover [PDF]

eLife
ATAD2, a conserved protein which is predominantly expressed in embryonic stem (ES) cells and spermatogenic cells, emerges as a crucial regulator of chromatin plasticity. Our previous parallel studies conducted in both ES cells and S.
Ariadni Liakopoulou, Fayçal Boussouar, Daniel Perazza, Sophie Barral, Emeline Lambert, Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Charlyne Gard, Denis Puthier, Sophie Rousseaux, Christophe Arnoult, André Verdel, Saadi Khochbin   +13 more
doaj   +2 more sources

Histones, histone chaperones and nucleosome assembly [PDF]

Protein & Cell, 2010
Chromatin structure governs a number of cellular processes including DNA replication, transcription, and DNA repair. During DNA replication, chromatin structure including the basic repeating unit of chromatin, the nucleosome, is temporarily disrupted, and then reformed immediately after the passage of the replication fork.
Rebecca J, Burgess, Zhiguo, Zhang
openaire   +2 more sources

Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus

FEBS Open Bio, 2021
Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually just regarded as an apoptotic trigger.
Katiuska González‐Arzola, Alejandra Guerra‐Castellano, Francisco Rivero‐Rodríguez, Miguel Á. Casado‐Combreras, Gonzalo Pérez‐Mejías, Antonio Díaz‐Quintana, Irene Díaz‐Moreno, Miguel A. De la Rosa   +7 more
doaj   +1 more source