Histone Variants and Their Chaperones in Hematological Malignancies [PDF]
HemaSphere, 2023 Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins.
Ecem Kirkiz +3 more
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Histone chaperones regulate histone exchange during transcription [PDF]
The EMBO Journal, 2007 Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway,
Hye-Jin, Kim +4 more
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Coordination of histone chaperones for parental histone segregation and epigenetic inheritance. [PDF]
Genes DevChromatin-based epigenetic memory relies on the accurate distribution of parental histone H3–H4 tetramers to newly replicated DNA strands. Mcm2, a subunit of the replicative helicase, and Dpb3/4, subunits of DNA polymerase ε, govern parental histone H3–H4 deposition to the lagging and leading strands, respectively.
Fang Y +6 more
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The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast. [PDF]
PLoS ONE, 2015 In the meiotic prophase, programmed DNA double-strand breaks (DSB) are introduced along chromosomes to promote homolog pairing and recombination. Although meiotic DSBs usually occur in nucleosome-depleted, accessible regions of chromatin, their repair by
Elsa Brachet +3 more
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Histone acetylation-independent transcription stimulation by a histone chaperone [PDF]
Nucleic Acids Research, 2006 Histone chaperones are thought to be important for maintaining the physiological activity of histones; however, their exact roles are not fully understood. The physiological function of template activating factor (TAF)-I, one of the histone chaperones, also remains unclear; however, its biochemical properties have been well studied.
Kato, Kohsuke +3 more
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Chaperoning the histone H3 family
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012 Chromatin is a highly dynamic nucleoprotein structure, which orchestrates all nuclear process from DNA replication to DNA repair, fromtranscription to recombination. The proper in vivo assembly of nucleosome, the basic repeating unit of chromatin, requires the deposition of two H3-H4 dimer pairs followed by the addition of two dimers of H2A and H2B ...
Ali, Hamiche, Muhammad, Shuaib
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Histone Chaperones and Digestive Cancer: A Review of the Literature. [PDF]
Cancers (Basel), 2022 Background: The global burden of digestive cancer is expected to increase. Therefore, crucial for the prognosis of patients with these tumors is to identify early diagnostic markers or novel therapeutic targets.
Zhao Z, Cai Z, Jiang T, Han J, Zhang B.
europepmc +2 more sources
ATP-dependent chromatin remodeling by Cockayne syndrome protein B and NAP1-like histone chaperones is required for efficient transcription-coupled DNA repair. [PDF]
PLoS Genetics, 2013 The Cockayne syndrome complementation group B (CSB) protein is essential for transcription-coupled DNA repair, and mutations in CSB are associated with Cockayne syndrome--a devastating disease with complex clinical features, including the appearance of ...
Iltaeg Cho +4 more
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The Effect of the Histone Chaperones HSPA8 and DEK on Tumor Immunity in Hepatocellular Carcinoma. [PDF]
Int J Mol Sci, 2023 Complex immune contexture leads to resistance to immunotherapy in hepatocellular carcinoma (HCC), and the need for new potential biomarkers of immunotherapy in HCC is urgent.
Yang C +7 more
europepmc +2 more sources
Towards a mechanism for histone chaperones. [PDF]
Biochim Biophys Acta, 2013 Histone chaperones can be broadly defined as histone-binding proteins that influence chromatin dynamics in an ATP-independent manner. Their existence reflects the importance of chromatin homeostasis and the unique and unusual biochemistry of the histone proteins.
Elsässer SJ, D'Arcy S.
europepmc +5 more sources