Results 51 to 60 of about 31,902 (257)
ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Chioda, Mariacristina +2 more
core +1 more source
Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]
, 2013 Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
core +1 more source
The yeast histone chaperone hif1p functions with RNA in nucleosome assembly. [PDF]
PLoS ONE, 2014 Hif1p is an H3/H4-specific histone chaperone that associates with the nuclear form of the Hat1p/Hat2p complex (NuB4 complex) in the yeast Saccharomyces cerevisiae. While not capable of depositing histones onto DNA on its own, Hif1p can act in conjunction
Amy R Knapp, Huanyu Wang, Mark R Parthun
doaj +1 more source
Histone Variants and Their Chaperones in Hematological Malignancies
HemaSphere, 2023 Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins. While canonical histone proteins are incorporated into chromatin through a replication-coupled process, structural variants of histones, commonly named histone ...
Kirkiz, Ecem +3 more
openaire +3 more sources
Histone chaperone-mediated nucleosome assembly process. [PDF]
PLoS ONE, 2015 A huge amount of information is stored in genomic DNA and this stored information resides inside the nucleus with the aid of chromosomal condensation factors.
Hsiu-Fang Fan +4 more
doaj +1 more source
The histone variant H3.3 regulates the transcription of the hepatitis B virus
Annals of Hepatology, 2021 Introduction and Objectives: About 250 million people around the world are chronically infected with the hepatitis B virus (HBV). Those people are at risk of developing hepatocellular carcinoma.
Francisca Alvarez-Astudillo +5 more
doaj +1 more source
Dissecting the roles of histone deacetylase 1 and 2 in the hematopoietic system [PDF]
, 2008 Reversible histone acetylation on lysine residues has been intensively studied as an epigenetic mark for gene activation in a variety of eukaryotes. Histone deacetylases (HDACs) act to repress gene expression by removing acetyl groups from histones and ...
Yamaguchi, Teppei
core +1 more source
A Developmental Requirement for HIRA-Dependent H3.3 Deposition Revealed at Gastrulation in Xenopus
Cell Reports, 2012 Discovering how histone variants that mark distinct chromatin regions affect a developmental program is a major challenge in the epigenetics field. To assess the importance of the H3.3 histone variant and its dedicated histone chaperone HIRA, we used an ...
Emmanuelle Szenker +2 more
doaj +1 more source
Histone Chaperones: Modulators of Chromatin Marks [PDF]
Molecular Cell, 2011 The many factors that control chromatin biology play key roles in essential nuclear functions like transcription, DNA damage response and repair, recombination, and replication and are critical for proper cell-cycle progression, stem cell renewal, differentiation, and development. These players belong to four broad classes: histone modifiers, chromatin
Avvakumov, Nikita +2 more
openaire +2 more sources
Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription [PDF]
, 2005 Histone chaperones are a group of proteins that aid in the dynamic chromatin organization during different cellular processes. Here, we report that the human histone chaperone nucleophosmin interacts with the core histones H3, H2B, and H4 but that this ...
Kishore, A. Hari +3 more
core +1 more source