Results 61 to 70 of about 31,902 (257)
Regulation of replicative histone RNA metabolism by the histone chaperone ASF1
Molecular Cell, 2022 SUMMARY In S phase, duplication and assembly of the whole genome into chromatin requires upregulation of replicative histone gene expression. Here, we explored a potential role of histone chaperones in this process thereby linking chromatin assembly with histone production in human cells.
Mendiratta, Shweta +6 more
openaire +3 more sources
Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex [PDF]
, 2015 Histone chaperones bind specific histones to mediate their storage, eviction or deposition from/or into chromatin. The HIRA histone chaperone complex, composed of HIRA, ubinuclein-1 (UBN1) and CABIN1, cooperates with the histone chaperone ASF1a to ...
Henry Hoff +17 more
core +1 more source
Chz1, a Nuclear Chaperone for Histone H2AZ [PDF]
Molecular Cell, 2007 The histone variant H2AZ marks nucleosomes flanking the promoters of most genes of budding yeast. The incorporation of H2AZ into chromatin is dependent on the SWR1 complex, which catalyses the replacement of conventional histone H2A with H2AZ. In cells, the pool of unincorporated histone H2AZ has previously been found in association with Nap1, a ...
Luk, Ed +10 more
openaire +2 more sources
mBio, 2021 Histone chaperoning ensures genomic integrity during routine processes such as DNA replication and transcription as well as DNA repair upon damage. Here, we identify a nuclear J domain protein, Dnj4, in the fungal pathogen Cryptococcus neoformans and ...
Linda C. Horianopoulos +7 more
doaj +1 more source
Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75 [PDF]
, 2011 Histone acetylation and nucleosome remodeling regulate DNA damage repair, replication and transcription. Rtt109, a recently discovered histone acetyltransferase (HAT) from Saccharomyces cerevisiae, functions with the histone chaperone Asf1 to acetylate ...
Keck, James G. +7 more
core +2 more sources
Enhanced ESC phenotype by histone variant and chaperone mutations. [PDF]
, 2016 Enhanced ESC phenotype by histone variant and chaperone mutations.
Devendran A. Sadasivam (2541448) +1 more
core +1 more source
Epigenetics & Chromatin, 2021 Background Asf1 is a well-conserved histone chaperone that regulates multiple cellular processes in different species. Two paralogous genes, Asf1a and Asf1b exist in mammals, but their role during fertilization and early embryogenesis remains to be ...
Xuemei Wang +7 more
doaj +1 more source
eLife, 2022 A newly discovered pathway suggests histone proteins H3 and H4 are imported into the nucleus as individual units rather than joined together as heterodimers as was previously thought.
Hongyu Bao, Hongda Huang
doaj +1 more source
The histone chaperone FACT modulates nucleosome structure by tethering its components
Life Science Alliance, 2018 The histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.
Tao Wang +5 more
doaj +1 more source
Nature Communications, 2018 The HIRA histone chaperone complex is involved in the deposition of the histone variant H3.3. Here the authors, by using biochemical and crystallographic approaches, report the homotrimerization of the HIRA subunit which is critical for the functional ...
Dominique Ray-Gallet +7 more
doaj +1 more source