Chromatin Assembly and Disassembly
The FASEB Journal, 2013 The eukaryotic genome is packaged together with histone proteins to form the nucleoprotein structure called chromatin. This packaging of DNA into chromatin is critical to prevent inappropriate access to the DNA in order to enable the fundamental processes of the genome, such as gene expression, DNA repair and DNA replication, to be highly regulated ...
jessica Tyler
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The histone chaperone FACT modulates nucleosome structure by tethering its components
Life Science Alliance, 2018 The histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.
Tao Wang +5 more
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Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus
FEBS Open Bio, 2021 Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually just regarded as an apoptotic trigger.
Katiuska González‐Arzola +7 more
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The mechanism and consequences of chromatin assembly and disassembly [PDF]
Epigenetics & Chromatin, 2013 The Eukaryotic genome is packaged together with histone proteins to form the nucleoprotein structure called chromatin. This packaging of DNA into chromatin is critical to prevent inappropriate access to the DNA in order to enable the fundamental processes of the genome, such as gene expression, DNA repair and DNA replication, to be highly regulated ...
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ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Chioda, Mariacristina +2 more
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Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability [PDF]
, 2023 Chromatin is dynamically reorganized when DNA replication forks are challenged. However, the process of epigenetic reorganization and its implication for fork stability is poorly understood.
Simone Sidoli +44 more
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FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1. [PDF]
PLoS Genetics, 2010 The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT subunits, alter the expression of G1 cyclins and exhibit defects in the G1/S ...
Macarena Morillo-Huesca +9 more
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Chromatin Assembly and Disassembly During Genomic Processes
The FASEB Journal, 2008 Chromatin assembly and disassembly has long been acknowledged to accompany the process of DNA replication. Accordingly, we previously discovered a key histone chaperone involved in the assembly of chromatin during DNA replication, termed Asf1 (Tyler et al., Nature 1999).
Jessica K Tyler +3 more
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A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans. [PDF]
PLoS Genetics, 2012 Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevisiae and Candida albicans. These kinetochores are clustered together throughout the cell cycle.
Jitendra Thakur, Kaustuv Sanyal
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Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms [PDF]
, 2007 Alteration of chromatin structure by chromatin modifying and remodelling activities is a key stage in the regulation of many nuclear processes. These activities are frequently interlinked, and many chromatin remodelling enzymes contain motifs that ...
Owen-Hughes, Tom; id_orcid +3 more
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