Results 11 to 20 of about 31,713 (195)

Effective dynamics of nucleosome configurations at the yeast PHO5 promoter

eLife, 2021
Chromatin dynamics are mediated by remodeling enzymes and play crucial roles in gene regulation, as established in a paradigmatic model, the Saccharomyces cerevisiae PHO5 promoter. However, effective nucleosome dynamics, that is, trajectories of promoter
Michael Roland Wolff, Andrea Schmid, Philipp Korber, Ulrich Gerland   +3 more
doaj   +1 more source

Nucleosome proteostasis and histone turnover

Frontiers in Molecular Biosciences, 2022
Maintenance of protein folding homeostasis, or proteostasis is critical for cell survival as well as for execution of cell type specific biological processes such as muscle cell contractility, neuronal synapse and memory formation, and cell transition ...
Adrian Arrieta, Thomas M. Vondriska, Thomas M. Vondriska, Thomas M. Vondriska   +3 more
doaj   +1 more source

Structural comparisons reveal diverse binding modes between nucleosome assembly proteins and histones

Epigenetics & Chromatin, 2022
Nucleosome assembly proteins (NAPs) are histone chaperones that play a central role in facilitating chromatin assembly/disassembly which is of fundamental importance for DNA replication, gene expression regulation, and progression through the cell cycle.
Jasmita Gill, Anuj Kumar, Amit Sharma
doaj   +1 more source

The histone chaperone FACT modulates nucleosome structure by tethering its components

Life Science Alliance, 2018
The histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.
Tao Wang, Yang Liu, Garrett Edwards, Daniel Krzizike, Hataichanok Scherman, Karolin Luger   +5 more
doaj   +1 more source

ATP-dependent chromatosome remodeling [PDF]

, 2008
Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S., Langst G., Loyola A., Ner S.S., Shogren-Knaak M., Varga-Weisz P.D., Wisniewski J.R.   +6 more
core   +1 more source

Nuclear inclusion of nontargeted and chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles [PDF]

, 2011
The nuclear membrane is one of the major cellular barriers in the delivery of plasmid DNA (pDNA). Cell division has a positive influence on the expression efficiency since, at the end of mitosis, pDNA or pDNA containing complexes near the chromatin are ...
De Smedt, Stefaan, Demeester, Jo, Mattaj, Iain, Remaut, Katrien, Symens, Nathalie, Walczak, Rudolf   +5 more
core   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus

FEBS Open Bio, 2021
Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually just regarded as an apoptotic trigger.
Katiuska González‐Arzola, Alejandra Guerra‐Castellano, Francisco Rivero‐Rodríguez, Miguel Á. Casado‐Combreras, Gonzalo Pérez‐Mejías, Antonio Díaz‐Quintana, Irene Díaz‐Moreno, Miguel A. De la Rosa   +7 more
doaj   +1 more source

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution [PDF]

, 2013
NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a ...
Andrew Bowman, Andrew Stirling, Andrews, Berndsen, Bonangelino, Bowman, Colin M. Hammond, Das, David A. Robinson, David G. Norman, Del Rosario, Dmitri I. Svergun, Driscoll, D’Arcy, D’Arcy, Fillingham, Fleissner, Hagelueken, Hansen, Hassane El-Mkami, Ishimi, Jeschke, Kolonko, Konarev, Krogan, Kuryan, Laskey, McBryant, McBryant, Milov, Newman, Noda, Ohkuni, Park, Park, Petoukhov, Pramila, Ransom, Richard Ward, Roessle, Schwieters, Selth, Selth, Su, Svergun, Svergun, Tang, Tang, Tom Owen-Hughes, Toth, Tsubota, Ward, Weifeng Shang, Xue   +53 more
core   +8 more sources

FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1. [PDF]

PLoS Genetics, 2010
The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT subunits, alter the expression of G1 cyclins and exhibit defects in the G1/S ...
Macarena Morillo-Huesca, Douglas Maya, Mari Cruz Muñoz-Centeno, Rakesh Kumar Singh, Vincent Oreal, Gajjalaiahvari Ugander Reddy, Dun Liang, Vincent Géli, Akash Gunjan, Sebastián Chávez   +9 more
doaj   +1 more source