Results 21 to 30 of about 31,713 (195)

TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. [PDF]

, 2015
The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset.
Bhalla, Needhi, Chen, Pin-Hsi, Hwang, Tom, Nelson, Christian R   +3 more
core   +1 more source

CUL-2^LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis [PDF]

, 2017
Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase (CDC45-MCM-GINS).
A Franz, A Franz, A Franz, A Gambus, A Gambus, A Gambus, A Saha, A Sarikas, Agnieszka Gambus, Anton Gartner, Axel Knebel, B Hodgson, B Ossareh-Nazari, B Vaz, C. James Hastie, Clare Johnson, CW Menges, D Avci, DM Duda, DR Semlow, DW Lee, F Pelisch, G Fullbright, GA Khoudoli, H Meyer, H Morohashi, HH Meyer, I Ilves, J Merlet, J Mouysset, JC Walter, JJ Lee, JM Dewar, K Labib, Karim Labib, L Timmons, M Maric, M O’Donnell, ML Edgley, NG Starostina, O Cuvier, P Kloppsteck, PJ Gillespie, R Sonneville, R Sonneville, Remi Sonneville, S Bandau, S Brenner, S Heubes, S Sengupta, Sara Priego Moreno, SE Moyer, SP Bell, SP Bell, SP Moreno, T Maculins, TA Prokhorova, TA Soucy, TD Deegan, WJ Sharrock   +59 more
core   +2 more sources

A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans. [PDF]

PLoS Genetics, 2012
Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevisiae and Candida albicans. These kinetochores are clustered together throughout the cell cycle.
Jitendra Thakur, Kaustuv Sanyal
doaj   +1 more source

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization [PDF]

, 2013
The origin recognition complex (ORC) of Saccharomyces cerevisiae binds origin DNA and cooperates with Cdc6 and Cdt1 to load the replicative helicase MCM2–7 onto DNA. Helicase loading involves two MCM2–7 hexamers that assemble into a double hexamer around
A. Fernandez-Cid, A. Riera, Bell, Bowers, Bray, C. Evrin, C. Speck, Casas-Terradellas, Chen, Cocker, Coleman, Costa, Donovan, Dueber, Gillespie, Herbig, Holm, J. Zech, Klemm, Krupinski, Laemmli, Liang, Liang, Liu, M. C. Herrera, Mizushima, Neuwald, P. Clarke, Perkins, R. Lurz, Randell, Remus, Remus, Roy, S. Brill, Schepers, Seki, Singleton, Steven, Stoeber, Takara, Tanaka, Watanabe, Weinreich, Wendler, Williams, Ying, Zhang   +47 more
core   +1 more source

Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]

, 2017
The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D, Komives, Elizabeth A, West, Alan MV   +2 more
core   +2 more sources

Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction [PDF]

, 2019
p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their ...
Long, David T., Rycenga, Halley B., Wolfe, Kelly B., Yeh, Elizabeth S.   +3 more
core   +1 more source

Quantitative analysis of the transcription control mechanism

Molecular Systems Biology, 2010
Gene transcription requires a sequence of promoter state transitions, including chromatin remodeling, assembly of the transcription machinery, and clearance of the promoter by RNA polymerase.
Changhui Mao, Christopher R Brown, Elena Falkovskaia, Shawfeng Dong, Eva Hrabeta‐Robinson, Lauren Wenger, Hinrich Boeger   +6 more
doaj   +1 more source

DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation [PDF]

, 2015
The acquisition of endocrine therapy resistance in estrogen receptor a (ERa) breast cancer patients represents a major clinical problem. Notch signalling has been extensively linked to breast cancer especially in patients who fail to respond to endocrine
Aifantis, Apatira, Apweiler, Brennan, Carroll, Chazotte, Chen, Coombes, Darbre, Eikesdal, Forgac, Goloubeva, Gul, Hill, Ho, Joffe, Johnston, Jones, Jones, Jones, Kane, Kang, Kocak, Lake, Le Borgne, Lendahl, Liu, Lupien, Mader, Mao, Martinez, McPherson, Medici, Meyer, Miele, Miele, Miele, Miyamoto, Nguyen, Nicolson, Roegiers, Sarkar, Schiff, Schilling, Schupbach, Sutherland, Taylor, Urbe, Vaccari, Venkanteshan, Wang, Webster, Wieczorek, Wong, Zahler   +54 more
core   +3 more sources

Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly

eLife, 2016
The cell achieves DNA double-strand break (DSB) repair in the context of chromatin structure. However, the mechanisms used to expose DSBs to the repair machinery and to restore the chromatin organization after repair remain elusive.
Xuan Li, Jessica K Tyler
doaj   +1 more source

Kinetochore assembly: if you build it, they will come [PDF]

, 2010
Accurate chromosome segregation requires the interaction of chromosomes with the microtubules from the mitotic spindle. This interaction is mediated by the macro-molecular kinetochore complex, which assembles only at the centromeric region of each ...
Cheeseman, Iain McPherson, Gascoigne, Karen E   +1 more
core   +1 more source