Results 31 to 40 of about 31,713 (195)

Histone deposition promotes recombination-dependent replication at arrested forks.

PLoS Genetics, 2019
Replication stress poses a serious threat to genome stability. Recombination-Dependent-Replication (RDR) promotes DNA synthesis resumption from arrested forks.
Julien Hardy, Dingli Dai, Anissia Ait Saada, Ana Teixeira-Silva, Louise Dupoiron, Fatemeh Mojallali, Karine Fréon, Francoise Ochsenbein, Brigitte Hartmann, Sarah Lambert   +9 more
doaj   +1 more source

Membraneless organelles: a smart design for metabolic control

FEBS Open Bio, 2021
While most organelles are surrounded by membranes, cells also contain membraneless organelles, which remain separated in the cell by avoiding the mixture of their components with the surroundings.
Irene Díaz‐Moreno, Miguel A. De la Rosa   +1 more
doaj   +1 more source

Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells [PDF]

, 2014
Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based
A Albini, A Cock-Rada, A Grigoriadis, An Wouters, AP Mazar, B Castellana, B Grin, B Jayaprakasam, D Hanahan, D Sarrio, Dariusz Ratman, DG Johnson, DR Hurst, ER Hahm, Erik Fransen, F Pereira, F Zambelli, Filip Lardon, G Chiappetta, G Natoli, GK Smyth, Guy Van Camp, H Yu, Ilse M. Beck, J Chia, J Lee, J Lee, JB Mitchem, JH Nijwening, JJ Steffan, JT Thaiparambil, K Belguise, K Miyazaki, Karen Heyninck, Karolien De Bosscher, Katarzyna Szarc vel Szic, KD Brown, Ken Declerck, Ken Op de Beeck, L Dumartin, L Ma, LC Mishra, LP Blair, M Endo, M Kaileh, M Tian, Marc Bracke, MD Edmonds, MJ Duffy, MJ Dunning, MN Ndlovu, N Brunner, N Pouliot, N Widodo, O De Wever, P Chi, PH O'Donnell, PJ Boimel, R Nanda, R Santana-Davila, Rajeev Samant, S Mirza, S Ramadoss, S Subbaram, SC Smith, SD Stan, SD Stan, SL Floor, TW Rockway, W Vanden Berghe, Wim Vanden Berghe, WL Berry, WW Bhat, Y He, YJ Surh   +74 more
core   +3 more sources

How the cell cycle impacts chromatin architecture and influences cell fate

Frontiers in Genetics, 2015
Since the earliest observations of cells undergoing mitosis, it has been clear that there is an intimate relationship between the cell cycle and nuclear chromatin architecture.
Yiqin eMa, Kiriaki eKanakousaki, Laura eButtitta   +2 more
doaj   +1 more source

Regulation of lamin properties and functions: does phosphorylation do it all? [PDF]

Open Biology, 2015
The main functions of lamins are their mechanical and structural roles as major building blocks of the karyoskeleton. They are also involved in chromatin structure regulation, gene expression, intracellular signalling pathway modulation and development ...
Magdalena Machowska, Katarzyna Piekarowicz, Ryszard Rzepecki   +2 more
doaj   +1 more source

Repo-Man/protein phosphatase 1 SUMOylation mediates binding to lamin A and serine 22 dephosphorylation

Open Biology, 2022
Lamin A phosphorylation/de-phosphorylation is an important process during cells division as it allows for nuclear envelope (NE) disassembly at mitotic entry and its re-assembly during mitotic exit.
Florentin Huguet, Ezgi Gokhan, Helen A. Foster, Hasnat A. Amin, Paola Vagnarelli   +4 more
doaj   +1 more source

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source

Dynamic Changes in Occupancy of Histone Variant H2A.Z during Induced Somatic Cell Reprogramming

Stem Cells International, 2016
The development of induced pluripotent stem cells (iPSCs) has enabled study of the mechanisms underlying cellular reprogramming. Here, we have studied the dynamic distribution of H2A.Z during induced reprogramming with chromatin immunoprecipitation deep ...
Fulu Dong, Zhenwei Song, Jiali Yu, Baole Zhang, BaoChun Jiang, Ying Shen, Youde Lu, Chunlei Song, Peiqing Cong, Honglin Liu   +9 more
doaj   +1 more source

Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. [PDF]

PLoS Genetics, 2007
To investigate the DNA damage response, we undertook a genome-wide study in Saccharomyces cerevisiae and identified 86 gene deletions that lead to increased levels of spontaneous Rad52 foci in proliferating diploid cells.
David Alvaro, Michael Lisby, Rodney Rothstein   +2 more
doaj   +1 more source

Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy

Frontiers in Molecular Biosciences, 2018
Cullin-RING (Really Interesting New Gene) E3 ubiquitin ligases (CRLs), the largest family of E3 ubiquitin ligases, are functional multi-subunit complexes including substrate receptors, adaptors, cullin scaffolds, and RING-box proteins.
Sang-Min Jang, Christophe E. Redon, Mirit I. Aladjem   +2 more
doaj   +1 more source