Regulation of lamin properties and functions: does phosphorylation do it all? [PDF]
Open Biology, 2015 The main functions of lamins are their mechanical and structural roles as major building blocks of the karyoskeleton. They are also involved in chromatin structure regulation, gene expression, intracellular signalling pathway modulation and development ...
Magdalena Machowska +2 more
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Open Biology, 2022 Lamin A phosphorylation/de-phosphorylation is an important process during cells division as it allows for nuclear envelope (NE) disassembly at mitotic entry and its re-assembly during mitotic exit.
Florentin Huguet +4 more
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Improved tools for efficient mapping of fission yeast genes:identification of microtubule nucleation modifier mod22-1 as an allele of chromatin- remodelling factor gene swr1 [PDF]
, 2008 Fission yeast genes identified in genetic screens are usually cloned by transformation of mutants with plasmid libraries. However, for some genes this can be difficult, and positional cloning approaches are required.
Sawin, Kenneth E +3 more
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Dynamic Changes in Occupancy of Histone Variant H2A.Z during Induced Somatic Cell Reprogramming
Stem Cells International, 2016 The development of induced pluripotent stem cells (iPSCs) has enabled study of the mechanisms underlying cellular reprogramming. Here, we have studied the dynamic distribution of H2A.Z during induced reprogramming with chromatin immunoprecipitation deep ...
Fulu Dong +9 more
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Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. [PDF]
PLoS Genetics, 2007 To investigate the DNA damage response, we undertook a genome-wide study in Saccharomyces cerevisiae and identified 86 gene deletions that lead to increased levels of spontaneous Rad52 foci in proliferating diploid cells.
David Alvaro +2 more
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Frontiers in Molecular Biosciences, 2018 Cullin-RING (Really Interesting New Gene) E3 ubiquitin ligases (CRLs), the largest family of E3 ubiquitin ligases, are functional multi-subunit complexes including substrate receptors, adaptors, cullin scaffolds, and RING-box proteins.
Sang-Min Jang +2 more
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Chromatin remodeling pathways in smooth muscle cell differentiation, and evidence for an integral role for p300. [PDF]
PLoS ONE, 2010 Phenotypic alteration of vascular smooth muscle cells (SMC) in response to injury or inflammation is an essential component of vascular disease. Evidence suggests that this process is dependent on epigenetic regulatory processes.
Joshua M Spin +2 more
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, 2021 As the elementary unit of eukaryotic chromatin, nucleosomes in vivo are highly dynamic in many biological processes, such as DNA replication, repair, recombination, or transcription, to allow the necessary factors to gain access to their substrate.
Mingxin Guo (669847) +8 more
core +1 more source
H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]
, 2013 Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Pünzeler, Sebastian +29 more
core +1 more source
Mechanism of curaxin-dependent nucleosome unfolding by FACT
Frontiers in Molecular Biosciences, 2022 Human FACT (FACT) is a multifunctional histone chaperone involved in transcription, replication and DNA repair. Curaxins are anticancer compounds that induce FACT-dependent nucleosome unfolding and trapping of FACT in the chromatin of cancer cells (c ...
Olesya I. Volokh +14 more
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