Results 51 to 60 of about 19,014 (210)

The role of emerin and LEM domain proteins in nuclear envelope assembly and cytoskeleton organisation [PDF]

, 2005
The nuclear envelope (NE) plays a fundamental role in the cell by separating nuclear from cytoplasmic activities, and mutations in NE proteins have been associated with a diverse array of diseases.
Saipingidou, Georgia, Salpingidou, Georgia   +1 more
core  

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation

eLife, 2017
Mitotic chromosome assembly remains a big mystery in biology. Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic chromatin remains unknown.
Ewa Piskadlo, Alexandra Tavares, Raquel A Oliveira   +2 more
doaj   +1 more source

The Modular Circuitry of Apicomplexan Cell Division Plasticity

Frontiers in Cellular and Infection Microbiology, 2021
The close-knit group of apicomplexan parasites displays a wide variety of cell division modes, which differ between parasites as well as between different life stages within a single parasite species. The beginning and endpoint of the asexual replication
Marc-Jan Gubbels, Isabelle Coppens, Kourosh Zarringhalam, Manoj T. Duraisingh, Klemens Engelberg   +4 more
doaj   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Evaluation of mammalian cell-free systems of nuclear assembly and disassembly

, 2005
Mammalian cell-free systems are very useful for the biochemical and structural study of nuclear disassembly and assembly. Through manipulation, the role of specific proteins in these processes can be investigated.
Vaillant, Dominique
core   +2 more sources

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

Nature Communications
The CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability.
Derek L. Bolhuis, Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas G. Brown, Michael J. Emanuele   +7 more
doaj   +1 more source

Characterization of anti-silencing factor 1 in Leishmania major

Memorias do Instituto Oswaldo Cruz, 2012
Anti-silencing factor 1 (ASF1) is a histone chaperone that contributes to the histone deposition during nucleosome assembly in newly replicated DNA. It is involved in chromatin disassembly, transcription activation and in the cellular response to DNA ...
Ricardo Scher, Juliana Bório Ferreira Garcia, Bruno Pascoalino, Sergio Schenkman, Angela Kaysel Cruz   +4 more
doaj   +1 more source

Bod1, a novel kinetochore protein required for chromosome biorientation [PDF]

, 2007
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein
McClelland, Sarah E., Khoudoli, Guennadi A., Swedlow, Jason R.; id_orcid, Andersen, Jens S., McAinsh, Andrew D., Andrew D. McAinsh, Swedlow, Jason R, Iain M. Porter, J. Julian Blow, Khoudoli, Guennadi A, Hunter, Christopher J., Blow, J. Julian; id_orcid, Guennadi A. Khoudoli, Jason R. Swedlow, Hunter, Christopher J, Sarah E. McClelland, Porter, Iain M, Porter, Iain M., Blow, J Julian, Andersen, Jens S; id_orcid, McClelland, Sarah E, Swedlow, Jason R., McAinsh, Andrew D, Blow, J. Julian, Jens S. Andersen, Christopher J. Hunter   +25 more
core   +1 more source