Results 51 to 60 of about 31,713 (195)

Chromosome Duplication in Saccharomyces cerevisiae [PDF]

, 2016
The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic cells, the assembly of the multi-enzyme replisomes that perform replication is divided into stages that occur at distinct phases of the cell cycle.
Abid Ali, Alabert, Alabert, Albert, Alcasabas, Allen, Amin, Antczak, Aparicio, Aparicio, Arias, Ayyagari, Bae, Bando, Bastos de Oliveira, Baxter, Bechhoefer, Bell, Bell, Belsky, Ben-Shahar, Berbenetz, Bermejo, Bermejo, Berndsen, Bianchi, Bleichert, Blitzblau, Blow, Bochman, Bochman, Boiteux, Borges, Bowers, Branzei, Branzei, Breier, Brewer, Brewer, Brewster, Broach, Bruck, Bruin, Buchman, Budd, Bylund, Calzada, Chan, Chang, Chang, Chen, Chen, Cheng, Chilkova, Choi, Clausen, Collins, Costa, Costa, Coster, Crabbe, Czajkowsky, Dahmann, Daigaku, Dalgaard, Das, Davey, Davé, De Koning, De Piccoli, Desany, Deshpande, Devault, Dewar, Diffley, Diffley, Diffley, Diffley, Dion, Dornreiter, Downs, Driscoll, Drury, Dua, Dutta, Eaton, Elledge, English, Evrin, Evrin, Evrin, Fachinetti, Fanning, Ferguson, Ferguson, Fernandez-Cid, Finley, Fiorani, Flanagan, Fletcher, Fletcher, Foltman, Francis, Friedel, Friedman, Frigola, Froelich, Fu, Gambus, Gambus, Gangloff, Garcia-Rodriguez, Garg, Gary, Ge, Georgescu, Georgescu, Ghodgaonkar, Godinho Ferreira, Green, Green, Greenfeder, Haering, Hanna, Hardy, Hartwell, Hawkins, Heller, Hennessy, Hickson, Hills, Hiraga, Hodgson, Hoege, Hogg, Hoggard, Hsiao, Huang, Huang, Huang, Huberman, Hurwitz, Iida, Ilves, Ivessa, Ivessa, Ivessa, Iyer, Jacob, Jacobson, Johnson, Kamimura, Kamimura, Kanellis, Kanemaki, Kanemaki, Kang, Kang, Kaplan, Katan-Khaykovich, Kato, Katou, Kaufman, Kaykov, Kegel, Kelly, Kesti, Khayrutdinov, Kim, Kitamura, Klein, Klemm, Knott, Knott, Kobayashi, Komata, Krings, Kubota, Kubota, Kunkel, Kunkel, Kunkel, Labib, Labib, Labib, Labib, Lahaye, Langston, Le, Lee, Lee, Lee, Lengronne, Li, Li, Li, Li, Liachko, Liachko, Linskens, Lipford, Liu, Liu, Looke, Lopez-Mosqueda, Lou, Lucchini, Lujan, Luke, Lydeard, Lyons, MacAlpine, Maculins, Maine, Makovets, Mantiero, Marahrens, Maric, Marston, Masumoto, Mattarocci, Mayer, Mayer, McGuffee, McInerney, Mohanty, Moldovan, Mori, Morohashi, Muramatsu, Nasmyth, Natsume, Natsume, Nguyen, Nguyen, Nick McElhinny, Nick McElhinny, Nick McElhinny, Oliveira, Oppikofer, Orphanides, Osborn, Paciotti, Paeschke, Paeschke, Pan, Papamichos-Chronakis, Papouli, Park, Parker, Pasero, Pavlov, Pellegrini, Perera, Pfander, Pohl, Prior, Pursell, Putnam, Quan, Radman-Livaja, Raghuraman, Ramer, Randell, Randell, Ransom, Rao, Rao, Reijns, Remus, Remus, Reyes-Lamothe, Richet, Ricke, Rolef Ben-Shahar, Rouse, Rowland, Rowley, Samel, Samora, Santocanale, Santocanale, Santocanale, Schalbetter, Schlesinger, Schneider, Scholes, Segal, Segurado, Segurado, Sekedat, Seki, Selth, Sengupta, Shcherbakova, Sheu, Sheu, Shimada, Shirahige, Shundrovsky, Siddiqui, Simmons, Simon, Simpson, Siow, Sjogren, Skibbens, Skibbens, Smith, Sogo, Speck, Stelter, Stevenson, Stinchcomb, Strom, Sun, Sun, Sun, Sundin, Szyjka, Szyjka, Takara, Takayama, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tercero, Tercero, Theis, Theis, Ticau, Toth, Tourriere, Travesa, Tsubota, Tsubota, Uhlmann, Uhlmann, Ulrich, Ulrich, Unal, Unal, van Attikum, van Deursen, Versini, Vestner, Villa, Vincent, Vogelauer, Waga, Wang, Warren, Watase, Weinert, Weinert, Weinreich, Wellinger, Whitehouse, Wilmes, Wilmes, Winkler, Wittmeyer, Wu, Wyrick, Wyrick, Xu, Yabuki, Yamasu, Yao, Yardimci, Yeeles, Yoshida, Yu, Yuan, Zegerman, Zegerman, Zegerman, Zhang, Zhang, Zhao, Zhao, Zhou, Zhou, Zhu, Zou, Zou, Zou, Zou   +390 more
core   +2 more sources

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast. [PDF]

PLoS Genetics, 2013
Centromeres are specialized chromatin regions marked by the presence of nucleosomes containing the centromere-specific histone H3 variant CENP-A, which is essential for chromosome segregation.
Ulrika Norman-Axelsson, Mickaël Durand-Dubief, Punit Prasad, Karl Ekwall   +3 more
doaj   +1 more source

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication [PDF]

, 2015
© 2015, Chang et al.To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly.
Speck, C
core   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases

eLife, 2017
For transcription through chromatin, RNA polymerase (Pol) II associates with elongation factors (EFs). Here we show that many EFs crosslink to RNA emerging from transcribing Pol II in the yeast Saccharomyces cerevisiae.
Sofia Battaglia, Michael Lidschreiber, Carlo Baejen, Phillipp Torkler, Seychelle M Vos, Patrick Cramer   +5 more
doaj   +1 more source

Kinesins relocalize the chromosomal passenger complex to the midzone for spindle disassembly. [PDF]

, 2018
Mitotic spindle disassembly after chromosome separation is as important as spindle assembly, yet the molecular mechanisms for spindle disassembly are unclear.
Avunie-Masala, Buvelot, Cheeseman, Chen, Cleary, Cormier, Cottingham, David G. Drubin, Foiani, Fridman, Georjana Barnes, Gruneberg, Hoyt, Hoyt, Hsu, Itziar Ibarlucea-Benitez, Jaqaman, Kang, Khmelinskii, Kotwaliwale, Longtine, Luke S. Ferro, Morawska, Movshovich, Murata-Hori, Nakajima, Nakajima, Nicholas, Nishimura, Norden, Petersen, Reck-Peterson, Saunders, Saunders, Shannon, Straight, Tarantino, Thomas, Varga, Woodruff, Woodruff, Xing, Zhang, Zimniak   +43 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenation

eLife, 2017
Mitotic chromosome assembly remains a big mystery in biology. Condensin complexes are pivotal for chromosome architecture yet how they shape mitotic chromatin remains unknown.
Ewa Piskadlo, Alexandra Tavares, Raquel A Oliveira   +2 more
doaj   +1 more source

The Modular Circuitry of Apicomplexan Cell Division Plasticity

Frontiers in Cellular and Infection Microbiology, 2021
The close-knit group of apicomplexan parasites displays a wide variety of cell division modes, which differ between parasites as well as between different life stages within a single parasite species. The beginning and endpoint of the asexual replication
Marc-Jan Gubbels, Isabelle Coppens, Kourosh Zarringhalam, Manoj T. Duraisingh, Klemens Engelberg   +4 more
doaj   +1 more source