Results 71 to 80 of about 19,014 (210)

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution [PDF]

, 2013
NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a ...
El-Mkami, H., Bowman, A., Dmitri I. Svergun, Hammond, C. M., Hassane El-mkami, Ward, R., David G. Norman, Ward, Richard, Norman, David G., Owen-Hughes, Tom; id_orcid, Svergun, Dmitri, El-Mkami, Hassane, Richard Ward, Stirling, A., Svergun, Dmitri I., Owen-Hughes, Tom, Norman, D. G., Stirling, Andrew, Andrew Stirling, Bowman, Andrew, Shang, Weifeng, Robinson, David A., El Mkami, Hassane, Colin M. Hammond, Andrew Bowman, Hammond, Colin M., Shang, W., Robinson, D. A., David A. Robinson, Weifeng Shang, Tom Owen-hughes, Owen-Hughes, T.   +31 more
core   +1 more source

The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase [PDF]

, 2022
Complex cellular processes are driven by the regulated assembly and disassembly of large multiprotein complexes. While we are beginning to understand the molecular mechanism for assembly of the eukaryotic DNA replication machinery (replisome), we still ...
Tarcan, Zeynep, Gambus, Agnieszka; id_orcid, Divyasree Poovathumkadavil, Gambus, Agnieszka, Poovathumkadavil, Divyasree, Zeynep Tarcan, Aggeliki Skagia, Skagia, Aggeliki, Agnieszka Gambus   +8 more
core   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Compositional and structural analysis of selected chromosomal domains from Saccharomyces cerevisiae

, 2012
In eukaryotic genomes, chromatin is the template of all nuclear processes including transcription, recombination and replication. Besides the wrapping of DNA in nucleosome core particles, eukaryotic chromatin is associated, interpreted and modified by ...
Hamperl, Stephan
core   +1 more source

Involvement of the lamin rod domain in heterotypic lamin interactions important for nuclear organization [PDF]

, 2001
The nuclear lamina is a meshwork of intermediate-type filament proteins (lamins) that lines the inner nuclear membrane. The lamina is proposed to be an important determinant of nuclear structure, but there has been little direct testing of this idea.
Tinglu Guan, Gerace, L, Eric C. Schirmer, Schirmer, Eric, Guan, T, Larry Gerace   +5 more
core   +1 more source

Redox‐responsive dual‐drug nanomedicine integrating cisplatin and trypsin for synergistic reversal of tumor chemoresistance

Smart Molecules, EarlyView.
This study presents a novel glutathione‐activatable prodrug nanomedicine (cRGD‐PEG‐PGlu‐NP (ssTrypsin & CDDP)) that co‐encapsulates cisplatin and a masked protease to combat cisplatin resistance. The dual‐drug system selectively targets resistant tumor cells, enhancing the efficacy of cisplatin while minimizing systemic toxicity.
Xiaolan Yin, Qi Wang, Ming Zhang, Cheng Zhang, Qixian Chen, Haidong Li, Yan Zhao, Yue Wang, Jingyun Wang, Liuwei Zhang, Hongyan Cui   +10 more
wiley   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Accessible chromatin upregulates circadian rhythm transcription factor NPAS2 to promote Ferroptosis Resistance in Gastric Cancer Cells

陆军军医大学学报
Objective To explore the impact of epigenetic remodeling-mediated regulation of circadian genes on ferroptosis in gastric cancer cells. Methods The data from Assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), bulk
LI Yaping, HU Xiao
doaj   +1 more source

Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery [PDF]

, 2014
Copyright @ 2014 Booth et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.When the nucleolus ...
Elizabeth Petfalski, Vagnarelli, Paola, Ponting, Christopher, David Tollervey, Earnshaw, William C, Imamoto, N, Petfalski, Elizabeth, Sanchez-Pulido, Luis, Giulia Vargiu, Takagi, M, Booth, DG, Luis Sanchez-Pulido, Tollervey, David, Ponting, Chris P, Petfalski, E, Ponting, CP, Vargiu, Giulia, Tollervey, D, Naoko Imamoto, Ponting, Chris P.; id_orcid, Earnshaw, William C., Daniel G Booth, Vagnarelli, P, Kumiko Samejima, Imamoto, Naoko, Booth, Daniel G, William C Earnshaw, Masatoshi Takagi, Samejima, Kumiko, Sanchez-Pulido, L, Vargiu, G, Booth, Daniel G., Chris P Ponting, Paola Vagnarelli, Takagi, Masatoshi, Samejima, K, Earnshaw, WC   +36 more
core   +1 more source