Results 81 to 90 of about 31,713 (195)

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, EarlyView.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

Towards a proteomics meta-classification [PDF]

, 2004
that can serve as a foundation for more refined ontologies in the field of proteomics. Standard data sources classify proteins in terms of just one or two specific aspects.
Kumar, Anand, Smith, Barry
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Accessible chromatin upregulates circadian rhythm transcription factor NPAS2 to promote Ferroptosis Resistance in Gastric Cancer Cells

陆军军医大学学报
Objective To explore the impact of epigenetic remodeling-mediated regulation of circadian genes on ferroptosis in gastric cancer cells. Methods The data from Assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), bulk
LI Yaping, HU Xiao
doaj   +1 more source

Uncovering a previously unknown function of polyphosphate in polyadenylated RNA‐induced amyloidogenesis of Hfq

The FEBS Journal, EarlyView.
Polyphosphate interaction with Hfq and RNA drives phase separation and amyloid self‐assembly, uncovering a previously unrecognized role for polyP in bacterial stress responses. Our findings reveal new insights into the molecular mechanisms of RNA‐mediated phase separation, highlighting the role of polyP as a key modulator of this process. Polyphosphate
Kevin Mosca, Florian Turbant, Sambhasan Banerjee, Frank Wien, Richard R. Sinden, Véronique Arluison   +5 more
wiley   +1 more source

B23/nucleophosmin is involved in regulation of adenovirus chromatin structure at late infection stages, but not in virus replication and transcription [PDF]

, 2012
B23/nucleophosmin has been identified in vitro as a stimulatory factor for replication of adenovirus DNA complexed with viral basic core proteins. In the present study, the in vivo function of B23 in the adenovirus life cycle was studied.
Komatsu Tetsuro, Nagata Kyosuke, Okuwaki Mitsuru, Samad Mohammad Abdus, 奧脇 暢, 小松 哲郎, 永田 恭介   +6 more
core   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Potential functions of histone H3.3 lysine 56 acetylation in mammals

Epigenetics, 2022
H3K56 acetylation (H3K56Ac) was first identified in yeast and has recently been reported to play important roles in maintaining genomic stability, chromatin assembly, DNA replication, cell cycle progression and DNA repair.
Lei Fang, Danqi Chen, Jingzi Zhang, Hongjie Li, Beatrix Bradford, Chunyuan Jin   +5 more
doaj   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Structural basis of nucleosome assembly by the Abo1 AAA+ ATPase histone chaperone [PDF]

, 2019
The fundamental unit of chromatin, the nucleosome, is an intricate structure that requires histone chaperones for assembly. ATAD2 AAA+???ATPases are a family of histone chaperones that regulate nucleosome density and chromatin dynamics.
A Fazly, A Gradolatto, A Kucukelbir, A Leitner, AL Yokom, Andres H. de la Peña, C Caron, C Das, C Gal, CR Sandate, Cristina Puchades, CY Zhou, EC Greene, EF Pettersen, EV Kalashnikova, Han Han, JP Erzberger, JR Kardon, JX Zou, JY Lee, K Luger, LG Trabuco, LM Lombardi, LM Lombardi, M Cattaneo, P Chen, PD Adams, PV Sauer, RD Vale, RJ Burgess, SE Glynn, SN Gates, SQ Zheng, T Fazio, T Uchihashi, T Wang, Y Morozumi, YJ Park, ZA Gurard-Levin   +38 more
core   +1 more source