Results 21 to 30 of about 109,383 (351)
Transcriptional Regulators Compete with Nucleosomes Post-replication
Cell, 2016 Srinivas Ramachandran, Steven Henikoff
exaly +2 more sources
Breaking the aging epigenetic barrier
Frontiers in Cell and Developmental Biology, 2022 Aging is an inexorable event occurring universally for all organisms characterized by the progressive loss of cell function. However, less is known about the key events occurring inside the nucleus in the process of aging.
Sweta Sikder +3 more
doaj +1 more source
An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
eLife, 2023 In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylation (
Kanishk Jain +29 more
doaj +1 more source
Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription
Cell Reports, 2020 Summary: Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized ...
Jatinder Kaur Gill +4 more
doaj +1 more source
Frontiers in Genetics, 2022 Tight packaging of DNA in chromatin severely constrains DNA accessibility and dynamics. In contrast, nucleosomes in active chromatin state are highly flexible, can exchange their histones, and are virtually “transparent” to RNA polymerases, which ...
Wladyslaw A. Krajewski
doaj +1 more source
Proceedings of the National Academy of Sciences, 1997 Archaeacontain histones that have primary sequences in common with eukaryal nucleosome core histones and a three-dimensional structure that is essentially only the histone fold. Here we report the results of experiments that document that archaeal histones compact DNAin vivointo structures similar to the structure formed by the histone (H3+H4)2tetramer
S L, Pereira +3 more
openaire +2 more sources
Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast
Epigenetics, 2022 Recent studies have unveiled an association between an L61R substitution within the human histone H3.3 protein and the presentation of neurodevelopmental disorders in two patients.
Alex Pablo-Kaiser +6 more
doaj +1 more source
The TFIIH complex is required to establish and maintain mitotic chromosome structure
eLife, 2022 Condensins compact chromosomes to promote their equal segregation during mitosis, but the mechanism of condensin engagement with and action on chromatin is incompletely understood.
Julian Haase +5 more
doaj +1 more source
Cell Reports, 2021 Summary: The ARID1A subunit of SWI/SNF chromatin remodeling complexes is a potent tumor suppressor. Here, a degron is applied to detect rapid loss of chromatin accessibility at thousands of loci where ARID1A acts to generate accessible minidomains of ...
Seraina Blümli +13 more
doaj +1 more source
Structural basis for the inhibition of cGAS by nucleosomes
Science, 2020 Saving a host cell from itself A fundamental mammalian defense mechanism against pathogens and damaged cellular DNA is to recognize DNA fragments in the cytosol and trigger an inflammatory response.
T. Kujirai +8 more
semanticscholar +1 more source