Results 31 to 40 of about 129,047 (304)

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution [PDF]

, 2013
NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a ...
El-Mkami, H., Bowman, A., Dmitri I. Svergun, Hammond, C. M., Hassane El-mkami, Ward, R., David G. Norman, Ward, Richard, Norman, David G., Owen-Hughes, Tom; id_orcid, Svergun, Dmitri, El-Mkami, Hassane, Richard Ward, Stirling, A., Svergun, Dmitri I., Owen-Hughes, Tom, Norman, D. G., Stirling, Andrew, Andrew Stirling, Bowman, Andrew, Shang, Weifeng, Robinson, David A., El Mkami, Hassane, Colin M. Hammond, Andrew Bowman, Hammond, Colin M., Shang, W., Robinson, D. A., David A. Robinson, Weifeng Shang, Tom Owen-hughes, Owen-Hughes, T.   +31 more
core   +1 more source

The Hypersaline Archaeal Histones HpyA and HstA Are DNA Binding Proteins That Defy Categorization According to Commonly Used Functional Criteria

mBio, 2023
Histone proteins are found across diverse lineages of Archaea, many of which package DNA and form chromatin. However, previous research has led to the hypothesis that the histone-like proteins of high-salt-adapted archaea, or halophiles, function ...
Saaz Sakrikar, Rylee K. Hackley, Mar Martinez-Pastor, Cynthia L. Darnell, Angie Vreugdenhil, Amy K. Schmid   +5 more
doaj   +1 more source

Elevated Plasma Histone H4 Levels Are an Important Risk Factor in the Development of Septic Cardiomyopathy

Balkan Medical Journal, 2020
Background:Myocardial impairment is a major complication and an important prognostic predictor of sepsis. Therefore, early and accurate diagnosis as well as timely management of septic cardiomyopathy is critical to achieve favorable outcomes.Aims:To ...
Nian-Fang Lu, Li Jiang, Bo Zhu, De-Gang Yang, Rui-Qiang Zheng, Jun Shao, Jing Yuan, Xiu-Ming Xi   +7 more
doaj   +1 more source

Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage

Biomolecules, 2023
Extracellular histones, part of the protein group known as damage-associated molecular patterns (DAMPs), are released from damaged or dying cells and can instigate cellular toxicity.
Mario C. Rico, Oscar Perez-Leal, Mary F. Barbe, Mamta Amin, Dennis J. Colussi, Magda L. Florez, Victor Olusajo, Dennise S. Rios, Carlos A. Barrero   +8 more
doaj   +1 more source

A novel role for lipid droplets in the organismal antibacterial response

eLife, 2012
We previously discovered histones bound to cytosolic lipid droplets (LDs); here we show that this forms a cellular antibacterial defense system. Sequestered on droplets under normal conditions, in the presence of bacterial lipopolysaccharide (LPS) or ...
Preetha Anand, Silvia Cermelli, Zhihuan Li, Adam Kassan, Marta Bosch, Robilyn Sigua, Lan Huang, Andre J Ouellette, Albert Pol, Michael A Welte, Steven P Gross   +10 more
doaj   +1 more source

Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype

, 2022
Jesús Beltrán-García,1– 3 Rebeca Osca-Verdegal,1,3 Daniel Pérez-Cremades,2,3 Susana Novella,2,3 Carlos Hermenegildo,2,3 Federico V Pallardó,1– 3 José Luis García-Giménez1– 3 1Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER ...
Hermenegildo C, Pallardó FV, Osca-Verdegal R, Beltrán-García J, Pérez-Cremades D, Novella S, García-Giménez JL   +6 more
core  

Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. [PDF]

, 2020
Microvascular thrombosis and blood-brain barrier (BBB) breakdown are key components of cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain swelling.
Toh, Cheng Hock, Taylor, Terrie E., Molyneux, Malcolm, Sam Kampondeni (114917), Moxon, Christopher A, Abrams, Simon T, Craig, Alister G, Abrams, Simon T., Taylor, Terrie E, James O'Donnell (7895615), Ko, Joo Yeon, García-Cardeña, Guillermo, Potchen, Michael, Kampondeni, Sam, Karl B Seydel (10940154), Toh, Cheng-Hock, Cheng-Hock Toh (739342), O'Donnell, James S., Niamh O'Regan (698186), Moxon, Christopher A., Toh, Cheng, McGuinness, Dagmara, Lane, Steven, Craig, Alister, O’Donnell, James S, Toh, Julien M.H., Seydel, Karl B., Yasir Alhamdi (611011), Wang, Guozheng, Storm, Janet, Simon T Abrams (10940165), Alhamdi, Yasir, O'Donnell, James S, Murphy, George, Alhamadi, Yasir, Alister G Craig (10940163), Julien M H Toh (10940148), Guozheng Wang (611014), Janet Storm (37473), George Murphy (214866), O’Regan, Niamh, Dagmara McGuinness (430856), Seydel, Karl B, Michael Potchen (3500972), Malcolm Molyneux (1711), O'Regan, Niamh, Steven Lane (347900), Joo Yeon Ko (10940151), Toh, Julien MH, Guillermo García-Cardenã (10940162), Terrie E Taylor (10940153), García- Cardeña, Guillermo, Christopher A Moxon (10940147)   +52 more
core   +1 more source

Antifungal Activity of Antimicrobial Peptides and Proteins against Aspergillus fumigatus

Journal of Fungi, 2020
Antimicrobial peptides and proteins (AMPs) provide an important line of defence against invading microorganisms. However, the activity of AMPs against the human fungal pathogen Aspergillus fumigatus remains poorly understood.
Eloise Ballard, Raif Yucel, Willem J. G. Melchers, Alistair J. P. Brown, Paul E. Verweij, Adilia Warris   +5 more
doaj   +1 more source

Phasor Histone FLIM-FRET Microscopy Maps Nuclear-Wide Nanoscale Chromatin Architecture With Respect to Genetically Induced DNA Double-Strand Breaks

Frontiers in Genetics, 2021
A DNA double-strand break (DSB) takes place in the context of chromatin, and there is increasing evidence for chromatin structure to play a functional role in DSB signaling and repair.
Jieqiong Lou, Jieqiong Lou, Ashleigh Solano, Ashleigh Solano, Zhen Liang, Zhen Liang, Elizabeth Hinde, Elizabeth Hinde   +7 more
doaj   +1 more source

Exploring the substrate scope of histone demethylases

, 2021
Post-translational modifications of histones play key roles in regulation of eukaryotic transcription and in epigenetics. Lysine methylation of histones is a dynamic balance between activity of methyl transferases and demethylases (KDMs).
Bonnici, Joanna
core   +1 more source