Results 31 to 40 of about 136,607 (295)
Current Approaches to Epigenetic Therapy
Epigenomes, 2023 Epigenetic therapy is a promising tool for the treatment of a wide range of diseases. Several fundamental epigenetic approaches have been proposed. Firstly, the use of small molecules as epigenetic effectors, as the most developed pharmacological method,
Ekaterina D. Griazeva +10 more
doaj +1 more source
Neutralizing the pathological effects of extracellular histones with small polyanions.
, 2020 Extracellular histones in neutrophil extracellular traps (NETs) or in chromatin from injured tissues are highly pathological, particularly when liberated by DNases.
Quah, Benjamin JC +14 more
core +1 more source
The Histone Database: an integrated resource for histones and histone fold-containing proteins [PDF]
Database, 2011 Eukaryotic chromatin is composed of DNA and protein components-core histones-that act to compactly pack the DNA into nucleosomes, the fundamental building blocks of chromatin. These nucleosomes are connected to adjacent nucleosomes by linker histones. Nucleosomes are highly dynamic and, through various core histone post-translational modifications and ...
Leonardo Mariño-Ramírez +6 more
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Structural Diversity of Bacterial Histones [PDF]
Histones are an important class of proteins involved in chromatin formation in eukaryotes and archaea. Bacteria have generally been thought to use other proteins to organize their genomes, but have recently been shown to contain genes that encode histone
Gupta, Nikhil
core +4 more sources
Biological applications of chemically modified recombinant histones [PDF]
, 2022 In eukaryotes, DNA is packaged into repeating units called nucleosomes, which consist of ~150 base pairs of DNA wrapped around eight proteins called histones.
Josephson, Brian
core +1 more source
A novel role for lipid droplets in the organismal antibacterial response
eLife, 2012 We previously discovered histones bound to cytosolic lipid droplets (LDs); here we show that this forms a cellular antibacterial defense system. Sequestered on droplets under normal conditions, in the presence of bacterial lipopolysaccharide (LPS) or ...
Preetha Anand +10 more
doaj +1 more source
The EMBO Reports, 2020 Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post-translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase, regulating the acetylation of both histone and non-histone proteins. However, the role of HAT1 in succinylation modulation remains unclear.
Guang Yang +14 more
openaire +3 more sources
Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
Frontiers in Immunology, 2019 Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure.
Binita Shrestha +8 more
doaj +1 more source
Balkan Medical Journal, 2020 Background:Myocardial impairment is a major complication and an important prognostic predictor of sepsis. Therefore, early and accurate diagnosis as well as timely management of septic cardiomyopathy is critical to achieve favorable outcomes.Aims:To ...
Nian-Fang Lu +7 more
doaj +1 more source
mBio, 2023 Histone proteins are found across diverse lineages of Archaea, many of which package DNA and form chromatin. However, previous research has led to the hypothesis that the histone-like proteins of high-salt-adapted archaea, or halophiles, function ...
Saaz Sakrikar +5 more
doaj +1 more source