Results 31 to 40 of about 138,386 (301)

Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage

Biomolecules, 2023
Extracellular histones, part of the protein group known as damage-associated molecular patterns (DAMPs), are released from damaged or dying cells and can instigate cellular toxicity.
Mario C. Rico, Oscar Perez-Leal, Mary F. Barbe, Mamta Amin, Dennis J. Colussi, Magda L. Florez, Victor Olusajo, Dennise S. Rios, Carlos A. Barrero   +8 more
doaj   +1 more source

Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype

, 2022
Jesús Beltrán-García,1– 3 Rebeca Osca-Verdegal,1,3 Daniel Pérez-Cremades,2,3 Susana Novella,2,3 Carlos Hermenegildo,2,3 Federico V Pallardó,1– 3 José Luis García-Giménez1– 3 1Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER ...
Hermenegildo C, Pallardó FV, Osca-Verdegal R, Beltrán-García J, Pérez-Cremades D, Novella S, García-Giménez JL   +6 more
core  

Antifungal Activity of Antimicrobial Peptides and Proteins against Aspergillus fumigatus

Journal of Fungi, 2020
Antimicrobial peptides and proteins (AMPs) provide an important line of defence against invading microorganisms. However, the activity of AMPs against the human fungal pathogen Aspergillus fumigatus remains poorly understood.
Eloise Ballard, Raif Yucel, Willem J. G. Melchers, Alistair J. P. Brown, Paul E. Verweij, Adilia Warris   +5 more
doaj   +1 more source

Phasor Histone FLIM-FRET Microscopy Maps Nuclear-Wide Nanoscale Chromatin Architecture With Respect to Genetically Induced DNA Double-Strand Breaks

Frontiers in Genetics, 2021
A DNA double-strand break (DSB) takes place in the context of chromatin, and there is increasing evidence for chromatin structure to play a functional role in DSB signaling and repair.
Jieqiong Lou, Jieqiong Lou, Ashleigh Solano, Ashleigh Solano, Zhen Liang, Zhen Liang, Elizabeth Hinde, Elizabeth Hinde   +7 more
doaj   +1 more source

Additional file 1 of Viral histones: pickpocket’s prize or primordial progenitor?

, 2022
Additional file 1: Table S1. Eukaryotic histones. Table S2. Cultured viral histones. Table S3.
Karim-Jean Armache (12674824), Paul B. Talbert (12674821), Steven Henikoff (12259929)   +2 more
core   +1 more source

Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis

Current Issues in Molecular Biology
Cellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta, Sauradeep Dutta, Payaningal R. Somanath, S. Priya Narayanan, Xiaoyun Wang, Duo Zhang   +5 more
doaj   +1 more source

Histones and histone modifications in protozoan parasites

Cellular Microbiology, 2006
Protozoan parasites are early branching eukaryotes causing significant morbidity and mortality in humans and livestock. Single-celled parasites have evolved complex life cycles, which may involve multiple host organisms, and strategies to evade host immune responses.
William J, Sullivan, Arunasalam, Naguleswaran, Sergio O, Angel   +2 more
openaire   +2 more sources

Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis

, 2020
Histones are typically located within the intracellular compartment, and more specifically, within the nucleus. When histones are located within the extracellular compartment, they change roles and become damage-associated molecular patterns (DAMPs ...
Wong, Keith H. K., Vanderburg, Charles R., Frydman, Galit H., Irimia, Daniel, Tompkins, Ronald G., Tessier, Shannon N., Fox, James G, Toner, Mehmet   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Proteomic Analysis of Serum Lysine Acetylation in Uyghur Patients With T2DM

Frontiers in Molecular Biosciences, 2022
Lysine acetylation is a reversible modification process after protein translation, which plays a key regulatory role in various metabolic diseases such as diabetes.
Liang Yin, Gang Feng, Chun Huang, Weijuan Cai   +3 more
doaj   +1 more source