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Current Approaches to Epigenetic Therapy
Epigenomes, 2023 Epigenetic therapy is a promising tool for the treatment of a wide range of diseases. Several fundamental epigenetic approaches have been proposed. Firstly, the use of small molecules as epigenetic effectors, as the most developed pharmacological method,
Ekaterina D. Griazeva +10 more
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The histone database: A comprehensive resource for histones and histone fold‐containing proteins [PDF]
Proteins: Structure, Function, and Bioinformatics, 2005 AbstractTheThe Histone Database is a curated and searchable collection of full‐length sequences and structures of histones and nonhistone proteins containing histone‐like folds, compiled from major public databases. Several new histone fold‐containing proteins have been identified, including the huntingtin‐interacting protein HYPM.
Leonardo, Mariño-Ramírez +3 more
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The EMBO Reports, 2020 Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post-translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase, regulating the acetylation of both histone and non-histone proteins. However, the role of HAT1 in succinylation modulation remains unclear.
Guang Yang +14 more
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A novel role for lipid droplets in the organismal antibacterial response
eLife, 2012 We previously discovered histones bound to cytosolic lipid droplets (LDs); here we show that this forms a cellular antibacterial defense system. Sequestered on droplets under normal conditions, in the presence of bacterial lipopolysaccharide (LPS) or ...
Preetha Anand +10 more
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Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
Frontiers in Immunology, 2019 Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure.
Binita Shrestha +8 more
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Balkan Medical Journal, 2020 Background:Myocardial impairment is a major complication and an important prognostic predictor of sepsis. Therefore, early and accurate diagnosis as well as timely management of septic cardiomyopathy is critical to achieve favorable outcomes.Aims:To ...
Nian-Fang Lu +7 more
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mBio, 2023 Histone proteins are found across diverse lineages of Archaea, many of which package DNA and form chromatin. However, previous research has led to the hypothesis that the histone-like proteins of high-salt-adapted archaea, or halophiles, function ...
Saaz Sakrikar +5 more
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Extracellular Acetylated Histone 3.3 Induces Inflammation and Lung Tissue Damage
Biomolecules, 2023 Extracellular histones, part of the protein group known as damage-associated molecular patterns (DAMPs), are released from damaged or dying cells and can instigate cellular toxicity.
Mario C. Rico +8 more
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Antifungal Activity of Antimicrobial Peptides and Proteins against Aspergillus fumigatus
Journal of Fungi, 2020 Antimicrobial peptides and proteins (AMPs) provide an important line of defence against invading microorganisms. However, the activity of AMPs against the human fungal pathogen Aspergillus fumigatus remains poorly understood.
Eloise Ballard +5 more
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Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis
Current Issues in Molecular BiologyCellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta +5 more
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