Results 11 to 20 of about 114,303 (263)
Biomedicines, 2022 Histones have a specific key role in the remodeling of chromatin and gene transcription. In the blood, free histones are damage-connected proteins. Myelin basic protein (MBP) is the major component of the myelin-proteolipid sheath of axons.
Georgy A. Nevinsky +2 more
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Frontiers in Microbiology, 2016 Histones are small polycationic proteins located in the cell nucleus. Together, DNA and histones are integral constituents of the nucleosomes. Upon apoptosis, necrosis and infection - induced cell death, histones are released from the cell.
Asaf Sol +4 more
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Histones, histone chaperones and nucleosome assembly [PDF]
Protein & Cell, 2010 Chromatin structure governs a number of cellular processes including DNA replication, transcription, and DNA repair. During DNA replication, chromatin structure including the basic repeating unit of chromatin, the nucleosome, is temporarily disrupted, and then reformed immediately after the passage of the replication fork.
Rebecca J, Burgess, Zhiguo, Zhang
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DNA and factor VII–activating protease protect against the cytotoxicity of histones
Blood Advances, 2017 : Circulating histones have been implicated as major mediators of inflammatory disease because of their strong cytotoxic effects. Histones form the protein core of nucleosomes; however, it is unclear whether histones and nucleosomes are equally cytotoxic.
Gerben Marsman +6 more
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Diseases, 2021 Lysine methylation is among the key posttranslational modifications to histones that contribute to epigenetic regulation. SMYD3 is a lysine methyltransferase that is essential for the proliferation of a range of tumorigenic cells. The findings that SMYD3
Dillon K. Jarrell +4 more
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Histone-Histone Interactions and Centromere Function [PDF]
Molecular and Cellular Biology, 2000 Cse4p is a structural component of the core centromere of Saccharomyces cerevisiae and is a member of the conserved CENP-A family of specialized histone H3 variants. The histone H4 allele hhf1-20 confers defects in core centromere chromatin structure and mitotic chromosome transmission.
L, Glowczewski +4 more
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The role of histones in the immune responses of aquatic invertebrates [PDF]
Invertebrate Survival Journal, 2013 Histones are primary components of eukaryotic chromatin and highly abundant in all animal cells. In addition to their important role in chromatin structure and transcriptional regulation, histones contribute to innate immune responses. In several aquatic
C Nikapitiya +2 more
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Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation
Cells, 2022 NETosis is a key host immune process against a pathogenic infection during innate immune activation, consisting of a neutrophil “explosion” and, consequently, NET formation, containing mainly DNA, histones, and other nuclear proteins.
Rebeca Osca-Verdegal +8 more
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H2A-H2B Histone Dimer Plasticity and Its Functional Implications
Cells, 2022 The protein core of the nucleosome is composed of an H3-H4 histone tetramer and two H2A-H2B histone dimers. The tetramer organizes the central 60 DNA bp, while H2A-H2B dimers lock the flanking DNA segments. Being positioned at the sides of the nucleosome,
Anastasiia S. Kniazeva +2 more
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The Histone Database: an integrated resource for histones and histone fold-containing proteins [PDF]
Database, 2011 Eukaryotic chromatin is composed of DNA and protein components-core histones-that act to compactly pack the DNA into nucleosomes, the fundamental building blocks of chromatin. These nucleosomes are connected to adjacent nucleosomes by linker histones. Nucleosomes are highly dynamic and, through various core histone post-translational modifications and ...
Leonardo Mariño-Ramírez +6 more
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