Results 11 to 20 of about 138,386 (301)
Bacterial and Archaeal Histones Structure DNA Differently [PDF]
, 2023 Histones are small DNA binding proteins that structure DNA. Eukaryotes use well conserved histones to wrap DNA into nucleosomes; discrete packages used to regulate gene expression and structure genomes. Most archaea also encode histones, such as HMfB and
Laursen, Shawn P.
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Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]
, 2013 Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Szabó, László +23 more
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The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]
, 2011 Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, Andrew +17 more
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DNA and factor VII–activating protease protect against the cytotoxicity of histones
Blood Advances, 2017 : Circulating histones have been implicated as major mediators of inflammatory disease because of their strong cytotoxic effects. Histones form the protein core of nucleosomes; however, it is unclear whether histones and nucleosomes are equally cytotoxic.
Gerben Marsman +6 more
doaj +1 more source
Histone-Histone Interactions and Centromere Function [PDF]
Molecular and Cellular Biology, 2000 Cse4p is a structural component of the core centromere of Saccharomyces cerevisiae and is a member of the conserved CENP-A family of specialized histone H3 variants. The histone H4 allele hhf1-20 confers defects in core centromere chromatin structure and mitotic chromosome transmission.
L, Glowczewski +4 more
openaire +2 more sources
The role of histones in the immune responses of aquatic invertebrates [PDF]
Invertebrate Survival Journal, 2013 Histones are primary components of eukaryotic chromatin and highly abundant in all animal cells. In addition to their important role in chromatin structure and transcriptional regulation, histones contribute to innate immune responses. In several aquatic
C Nikapitiya +2 more
doaj +1 more source
Histone Citrullination Mediates a Protective Role in Endothelium and Modulates Inflammation
Cells, 2022 NETosis is a key host immune process against a pathogenic infection during innate immune activation, consisting of a neutrophil “explosion” and, consequently, NET formation, containing mainly DNA, histones, and other nuclear proteins.
Rebeca Osca-Verdegal +8 more
doaj +1 more source
Structural Diversity of Bacterial Histones [PDF]
Histones are an important class of proteins involved in chromatin formation in eukaryotes and archaea. Bacteria have generally been thought to use other proteins to organize their genomes, but have recently been shown to contain genes that encode histone
Gupta, Nikhil
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LPS-Challenged Macrophages Release Microvesicles Coated With Histones
Frontiers in Immunology, 2018 Histones are the protein component of nucleosomes, which are the basic packing unit of chromatin. However, histones are also found in the blood, both as components of nucleosomes leaked out from dead cells, or expelled from neutrophils in the active ...
Rohini Ravindran Nair +5 more
doaj +1 more source
H2A-H2B Histone Dimer Plasticity and Its Functional Implications
Cells, 2022 The protein core of the nucleosome is composed of an H3-H4 histone tetramer and two H2A-H2B histone dimers. The tetramer organizes the central 60 DNA bp, while H2A-H2B dimers lock the flanking DNA segments. Being positioned at the sides of the nucleosome,
Anastasiia S. Kniazeva +2 more
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