Results 31 to 40 of about 11,616,495 (310)
Frontiers in Genetics, 2022 DNA double-strand breaks (DSBs) can be repaired through various pathways. Understanding how these pathways are regulated is of great interest for cancer research and optimization of gene editing.
Ruben Schep +5 more
doaj +1 more source
Nucleus and gene regulation [PDF]
Current Opinion in Cell Biology, 2006 At the close of a 1973 meeting on Chromosome Structure and Function, an observer commented that chromosomes resembled “a bad day at a macaroni factory” [1]. But things change. Only a few months later nucleosomes were discovered and within just a few more years it began to be appreciated that the nucleus is organized as functionally distinct domains ...
Thoru, Pederson, Robert H, Singer
openaire +2 more sources
Gene Regulation and Cellular Metabolism: An Essential Partnership
Trends in Genetics, 2020 It is recognized that cell metabolism is tightly connected to other cellular processes such as regulation of gene expression. Metabolic pathways not only provide the precursor molecules necessary for gene expression, but they also provide ATP, the ...
R. Carthew
semanticscholar +1 more source
PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription
Cell Reports, 2013 Polo-like kinase 1 (PLK1) is a key regulator of cell division and is overexpressed in many types of human cancers. Compared to its well-characterized role in mitosis, little is known about PLK1 functions in interphase.
Michael Wierer +6 more
doaj +1 more source
Mechanical determinants of chromatin topology and gene expression
Nucleus, 2022 The compaction of linear DNA into micrometer-sized nuclear boundaries involves the establishment of specific three-dimensional (3D) DNA structures complexed with histone proteins that form chromatin.
Rajiv Kumar Jha +2 more
doaj +1 more source
Gene Regulation in and out of Equilibrium.
Annual Review of Biophysics, 2020 Determining whether and how a gene is transcribed are two of the central processes of life. The conceptual basis for understanding such gene regulation arose from pioneering biophysical studies in eubacteria.
Felix Wong, J. Gunawardena
semanticscholar +1 more source
Metabolic regulation of gene expression by histone lactylation
Nature, 2019 The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells.
Di Zhang +23 more
semanticscholar +1 more source
SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
Nature Communications, 2018 The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ...
Shuai Wu +11 more
doaj +1 more source
TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection
JHEP Reports, 2020 Background & Aims: HDV infection induces the most severe form of human viral hepatitis. However, the specific reasons for the severity of the disease remain unknown.
Carla Usai +9 more
doaj +1 more source
The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element
Genome Biology, 2017 Background It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset of them are long non-coding RNAs (lncRNAs).
Oskar Marín-Béjar +12 more
doaj +1 more source