Results 21 to 30 of about 11,616,495 (310)
Gene Therapy for Acquired and Genetic Cholestasis
Biomedicines, 2022 Cholestatic diseases can be caused by the dysfunction of transporters involved in hepatobiliary circulation. Although pharmacological treatments constitute the current standard of care for these diseases, none are curative, with liver transplantation ...
Javier Martínez-García +4 more
doaj +1 more source
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
Science, 2015 Expression, genetic variation, and tissues Human genomes show extensive genetic variation across individuals, but we have only just started documenting the effects of this variation on the regulation of gene expression.
K. Ardlie +132 more
semanticscholar +1 more source
Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
Nature Communications, 2020 ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren +11 more
doaj +1 more source
Chromatin complex dependencies reveal targeting opportunities in leukemia
Nature Communications, 2023 Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia cells to discover compensatory non-lethal or synergistic lethal combinations with ...
Fadi J. Najm +11 more
doaj +1 more source
Argonaute—a database for gene regulation by mammalian microRNAs
Nucleic Acids Res., 2005 MicroRNAs (miRNAs) constitute a recently discovered class of small non-coding RNAs that regulate expression of target genes either by decreasing the stability of the target mRNA or by translational inhibition.
Priyanka Shahi +9 more
semanticscholar +1 more source
AMB Express, 2019 Epsilon toxin (Etx) produced by Clostridium perfringens types B and D, a major causative agent of enterotoxaemia causes significant economic losses to animal industry.
Himani Kaushik +5 more
doaj +1 more source
Differential analysis of gene regulation at transcript resolution with RNA-seq
Nature Biotechnology, 2012 Differential analysis of gene and transcript expression using high-throughput RNA sequencing (RNA-seq) is complicated by several sources of measurement variability and poses numerous statistical challenges.
C. Trapnell +5 more
semanticscholar +1 more source
Regulation of the Erythropoietin Gene [PDF]
Blood, 1999 Erythropoietin (Epo), the hormone that stimulates red blood cell production, is induced by hypoxia. We have utilized the human hepatoma cell line, Hep3B, to investigate the regulation of the Epo gene. We present evidence that the oxygen sensor in Hep3B cells is a heme protein.
B L, Ebert, H F, Bunn
openaire +4 more sources
Wellcome Open Research, 2018 Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly +6 more
doaj +1 more source
Proximity labeling identifies a repertoire of site-specific R-loop modulators
Nature Communications, 2022 R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan +6 more
doaj +1 more source