Results 41 to 50 of about 11,616,495 (310)
Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Metabolic plasticity allows cancer cells to adjust their metabolic phenotypes to adapt in hostile environments. There is an urgent need to understand the cross-talk between gene regulation and metabolic pathways underlying cancer metabolic ...
D. Jia +7 more
semanticscholar +1 more source
Structural basis underlying viral hijacking of a histone chaperone complex
Nature Communications, 2016 The Epstein-Barr virus tegument protein BNRF1 is required for the establishment of selective viral gene expression during latency and interacts with the histone chaperone DAXX.
Hongda Huang +6 more
doaj +1 more source
TRANSFAC® and its module TRANSCompel®: transcriptional gene regulation in eukaryotes
Nucleic Acids Res., 2005 The TRANSFAC® database on transcription factors, their binding sites, nucleotide distribution matrices and regulated genes as well as the complementing database TRANSCompel® on composite elements have been further enhanced on various levels.
V. Matys +15 more
semanticscholar +1 more source
Multi-locus CRISPRi targeting with a single truncated guide RNA
Nature CommunicationsA critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Functional characterization remains a challenge due to the abundance and complexity of candidate elements. Here,
Molly M. Moore +14 more
doaj +1 more source
TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance
Nature Communications, 2022 The authors reveal insights into miRNA tailing specificity of TENTs and their effect on miRNA levels by combinatory KOs of TENT2, TUT4 and TUT7. They show uridylation is linked to TENT2 and identify non-redundant functions between TUT4 and TUT7.
Acong Yang +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker +11 more
wiley +1 more source
The Penn State Protein Ladder system for inexpensive protein molecular weight markers
Scientific Reports, 2021 We have created the Penn State Protein Ladder system to produce protein molecular weight markers easily and inexpensively (less than a penny a lane). The system includes plasmids which express 10, 15, 20, 30, 40, 50, 60, 80 and 100 kD proteins in E. coli.
Ryan T. Santilli +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke +4 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2011 Invasiveness, cellular atypia, and proliferation are hallmarks of malignant gliomas. To effectively target each of these characteristics, it is important to understand their sequence during tumorigenesis. However, because most gliomas are diagnosed at an
Oltea Sampetrean +11 more
doaj +1 more source
Nature Communications, 2019 While genetic variation at chromatin loops is relevant for human disease, the relationships between contact propensity (the probability that loci at loops physically interact), genetics, and gene regulation are unclear.
William W. Greenwald +10 more
semanticscholar +1 more source