Results 31 to 40 of about 9,293,313 (313)
Disparate expression specificities coded by a shared Hox-C enhancer
eLife, 2020 Can a single regulatory sequence be shared by two genes undergoing functional divergence? Here we describe a single promiscuous enhancer within the Drosophila Antennapedia Complex, EO053, that directs aspects of the expression of two adjacent genes, pb ...
Steve W Miller, James W Posakony
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eLife, 2019 Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm ...
Jeehae Park +10 more
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Shared enhancer gene regulatory networks between wound and oncogenic programs
eLife, 2023 Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs, including apoptosis, proliferation, and cell migration ...
Swann Floc'hlay +14 more
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Activity-by-Contact model of enhancer-promoter regulation from thousands of CRISPR perturbations
Nature Genetics, 2019 Enhancer elements in the human genome control how genes are expressed in specific cell types and harbor thousands of genetic variants that influence risk for common diseases1–4. Yet, we still do not know how enhancers regulate specific genes, and we lack
C. Fulco +18 more
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Enhancers, enhancers – from their discovery to today’s universe of transcription enhancers [PDF]
Biological Chemistry, 2015 AbstractTranscriptional enhancers are short (200–1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes as key determinants of cell-
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From enhanced coinduction towards enhanced induction [PDF]
Proceedings of the ACM on Programming Languages, 2022 There exist a rich and well-developed theory of enhancements of the coinduction proof method, widely used on behavioural relations such as bisimilarity. We study how to develop an analogous theory for inductive behaviour relations, i.e., relations defined from inductive observables.
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Frontiers in Oncology, 2023 Breast cancer biology varies markedly among patients. Basal-like breast cancer is one of the most challenging subtypes to treat because it lacks effective therapeutic targets.
Kohei Kumegawa +4 more
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Frontiers in Physiology, 2021 Cardiac pacemaker cells differentiate and functionally specialize early in embryonic development through activation of critical gene regulatory networks.
Ravi Mandla +2 more
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The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 2019 The range of opportunities people enjoy in life largely depends on social, biological, and genetic factors for which individuals are not responsible. Philosophical debates about equality of opportunities have focussed mainly on addressing social determinants of inequalities.
Giubilini, A, Minerva, F
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Enhancer RNAs are an important regulatory layer of the epigenome
Nature Structural & Molecular Biology, 2020 Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing and translation.
V. Sartorelli, Shannon M. Lauberth
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