Results 31 to 40 of about 370,708 (316)
Enhancers, enhancers – from their discovery to today’s universe of transcription enhancers [PDF]
Biological Chemistry, 2015 AbstractTranscriptional enhancers are short (200–1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes as key determinants of cell-
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AdelmanLab/Enhancer-Annotation: CoGENT
, 2022 Connecting Genes to Enhancers with Nascent Transcriptomics Scripts developed by Andrew Field for the purpose of filtering and annotating enhancers peaks generated with dREG. dREG peaks are filtered by read count, p-value, and peak score with dRIP_filt.R.
arfield1
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Frontiers in Oncology, 2023 Breast cancer biology varies markedly among patients. Basal-like breast cancer is one of the most challenging subtypes to treat because it lacks effective therapeutic targets.
Kohei Kumegawa +4 more
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From enhanced coinduction towards enhanced induction [PDF]
Proceedings of the ACM on Programming Languages, 2022 There exist a rich and well-developed theory of enhancements of the coinduction proof method, widely used on behavioural relations such as bisimilarity. We study how to develop an analogous theory for inductive behaviour relations, i.e., relations defined from inductive observables.
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Frontiers in Physiology, 2021 Cardiac pacemaker cells differentiate and functionally specialize early in embryonic development through activation of critical gene regulatory networks.
Ravi Mandla +2 more
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, 2023 BackgroundSuper-enhancer (SE) refers to a regulatory element with super transcriptional activity, which can enrich transcription factors and drive gene expression. SE-related genes play an important role in the pathogenesis of malignant tumors, including
Qian Guo (107009) +15 more
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The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 2019 The range of opportunities people enjoy in life largely depends on social, biological, and genetic factors for which individuals are not responsible. Philosophical debates about equality of opportunities have focussed mainly on addressing social determinants of inequalities.
Giubilini, A, Minerva, F
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, 2023 BackgroundSuper-enhancer (SE) refers to a regulatory element with super transcriptional activity, which can enrich transcription factors and drive gene expression. SE-related genes play an important role in the pathogenesis of malignant tumors, including
Qian Guo (107009) +15 more
core +1 more source
Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene [PDF]
, 1989 In this paper we demonstrate that modulator sequences upstream of the enhancer of the major immediate-early promoter of human cytomegalovirus exert a differential effect on the level of transcription in a variety of cells and that this region has the ...
Lubon, H +6 more
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Cell-specific expression of the FAP gene is regulated by enhancer elements
Frontiers in Molecular Biosciences, 2023 Fibroblast activation protein (FAP) is an integral membrane serine protease that acts as both dipeptidyl peptidase and collagenase. In recent years, FAP has attracted considerable attention due to its specific upregulation in multiple types of tumor cell
Dina V. Antonova +11 more
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