Results 31 to 40 of about 293,755 (268)

Cell-specific expression of the FAP gene is regulated by enhancer elements

Frontiers in Molecular Biosciences, 2023
Fibroblast activation protein (FAP) is an integral membrane serine protease that acts as both dipeptidyl peptidase and collagenase. In recent years, FAP has attracted considerable attention due to its specific upregulation in multiple types of tumor cell
Dina V. Antonova, Dmitry A. Gnatenko, Elena S. Kotova, Victor V. Pleshkan, Victor V. Pleshkan, Alexey I. Kuzmich, Alexey I. Kuzmich, Dmitry A. Didych, Eugene D. Sverdlov, Irina V. Alekseenko, Irina V. Alekseenko, Irina V. Alekseenko   +11 more
doaj   +1 more source

A SNP uncoupling Mina expression from the TGFβ signaling pathway

Immunity, Inflammation and Disease, 2018
Introduction Mina is a JmjC family 2‐oxoglutarate oxygenase with pleiotropic roles in cell proliferation, cancer, T cell differentiation, pulmonary inflammation, and intestinal parasite expulsion.
Shang L. Lian, Belgacem Mihi, Madoka Koyanagi, Toshinori Nakayama, Mark Bix   +4 more
doaj   +1 more source

DIMETILSULFOKSID SEBAGAI ENHANCER TRANSPOR TRANSDERMAL TEOFILIN SEDIAAN GEL

Pharmaciana, 2013
Dimethylsulfoxide (DMSO) has been intensively studied the 19th century. This substance is used as a medicine and solve. It can also be used as an absorption enhancer of various drugs, either synthetical or herbal medicines.
Resty Annisa Damayanti, Tedjo Yuwono
doaj   +1 more source

Differential Requirement of Cd8 Enhancers E8I and E8VI in Cytotoxic Lineage T Cells and in Intestinal Intraepithelial Lymphocytes

Frontiers in Immunology, 2019
CD8 expression in T lymphocytes is tightly regulated by the activity of at least six Cd8 enhancers (E8I-E8VI), however their complex developmental stage-, subset-, and lineage-specific interplays are incompletely understood.
Alexandra Franziska Gülich, Teresa Preglej, Patricia Hamminger, Marlis Alteneder, Caroline Tizian, Maria Jonah Orola, Sawako Muroi, Ichiro Taniuchi, Wilfried Ellmeier, Shinya Sakaguchi   +9 more
doaj   +1 more source

Targeted screening of genetic associations with COVID-19 susceptibility and severity

Frontiers in Genetics, 2022
The COVID-19 pandemic has resulted in great morbidity and mortality worldwide and human genetic factors have been implicated in the susceptibility and severity of COVID-19.
Ping Li, Yuehua Ke, Wenlong Shen, Shu Shi, Yahao Wang, Kailin Lin, Xinjie Guo, Changjun Wang, Yan Zhang, Zhihu Zhao   +9 more
doaj   +1 more source

eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways

eLife, 2023
Cancer is driven by both genetic and epigenetic changes that impact on gene expression profiles and the resulting tumourigenic phenotype. Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring of gene ...
Ibrahim Ahmed, Shen-Hsi Yang, Samuel Ogden, Wei Zhang, Yaoyong Li, The OCCAMs consortium, Andrew D Sharrocks   +6 more
doaj   +1 more source

REDfly: An Integrated Knowledgebase for Insect Regulatory Genomics

Insects, 2022
We provide here an updated description of the REDfly (Regulatory Element Database for Fly) database of transcriptional regulatory elements, a unique resource that provides regulatory annotation for the genome of Drosophila and other insects.
Soile V. E. Keränen, Angel Villahoz-Baleta, Andrew E. Bruno, Marc S. Halfon   +3 more
doaj   +1 more source

HUBUNGAN POLA KONSUMSI SUMBER ZAT BESI, INHIBITOR DAN ENHANCER ZAT BESI DENGAN KEJADIAN ANEMIA PADA SANTRIWATI PONDOK PESANTREN AL-MIZAN MUHAMMADIYAH LAMONGAN
Correlation between consumption patterns of iron sources, iron inhibitor, and iron enhancer, with the occurence of anemia among female students in Islamic Boarding School Al-Mizan Muhammadiyah Lamongan

Media Gizi Indonesia, 2022
Anemia merupakan salah satu permasalahan defisiensi zat gizi yang rentan dialami oleh remaja putri. Anemia adalah kondisi dimana kadar hemoglobin (Hb) lebih rendah dari 12 g/dL. Anemia dapat disebabkan karena kekurangan darah, penyakit infeksi, rendahnya
Fanti Septia Nabilla, Lailatul Muniroh, Mahmud Aditya Rifqi   +2 more
doaj   +1 more source

Decoding regulatory associations of G-quadruplex with epigenetic and transcriptomic functional components

Frontiers in Genetics, 2022
G-quadruplex (G4) has been previously observed to be associated with gene expression. In this study, we performed integrative analysis on G4 multi-omics data from in-silicon prediction and ChIP-seq in human genome. Potential G4 sites were classified into
Shuyi Fang, Sheng Liu, Sheng Liu, Danzhou Yang, Danzhou Yang, Lei Yang, Lei Yang, Lei Yang, Chang-Deng Hu, Chang-Deng Hu, Jun Wan, Jun Wan, Jun Wan, Jun Wan   +13 more
doaj   +1 more source

Human Enhancement [PDF]

, 2011
Der Mensch strebt seit Urzeiten danach, seine Möglichkeiten zu erweitern und seine Leistungsfähigkeit zu steigern. Mittel dazu reichen von den ersten Werkzeugen bis zur Computertechnik, von der Erfindung des Buchdrucks bis zum drahtlosen Internet. Zunehmend beobachtbar ist die Tendenz, dass gesunde Personen Wirkstoffe zu sich nehmen in der Hoffnung auf
Eckhardt, Anne, Bachmann, Andreas, Marti, Michèle, Rütsche, Bernhard, Telser, Harry   +4 more
openaire   +4 more sources