Results 21 to 30 of about 370,708 (316)

The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]

, 1985
The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael, Schaffner, Walter, Weber, Frank, Dorsch-Häsler, Karoline, Jahn, Gerhard, Rüger, Rüdiger, Fleckenstein, Bernhard, Stoerker, Jay, Calendar, R., Gold, L.   +9 more
core   +1 more source

Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERα-positive breast cancer cells

Epigenetics, 2022
Aberrant DNA methylation is an epigenetic hallmark of malignant tumours. The DNA methylation level is regulated by not only DNA methyltransferases (DNMTs) but also Ten-Eleven Translocation (TET) family proteins.
Ruitu Lyu, Xuguo Zhu, Yinghui Shen, Lijun Xiong, Lu Liu, Hang Liu, Feizhen Wu, Christian Argueta, Li Tan   +8 more
doaj   +1 more source

Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

eLife, 2017
Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood.
Pierre Khoueiry, Charles Girardot, Lucia Ciglar, Pei-Chen Peng, E Hilary Gustafson, Saurabh Sinha, Eileen EM Furlong   +6 more
doaj   +1 more source

bianlab-hub/Chen_Sci_Adv_2022: enhancer

, 2022
Aberrations in tissue-specific enhancers underlie many developmental defects. Disrupting a noncoding region distal from the human SOX9 gene causes the Pierre Robin sequence (PRS) characterized by the undersized lower jaw.
bianlab-hub
core   +1 more source

Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis

Frontiers in Immunology, 2018
The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis.
Haeja Kessler, Kaiyu Jiang, James N. Jarvis, James N. Jarvis   +3 more
doaj   +1 more source

Disparate expression specificities coded by a shared Hox-C enhancer

eLife, 2020
Can a single regulatory sequence be shared by two genes undergoing functional divergence? Here we describe a single promiscuous enhancer within the Drosophila Antennapedia Complex, EO053, that directs aspects of the expression of two adjacent genes, pb ...
Steve W Miller, James W Posakony
doaj   +1 more source

Transcriptional control by enhancers and enhancer RNAs [PDF]

Transcription, 2019
The regulation of gene expression is a fundamental cellular process and its misregulation is a key component of disease. Enhancers are one of the most salient regulatory elements in the genome and help orchestrate proper spatiotemporal gene expression during development, in homeostasis, and in response to signaling.
Michael W. Lewis, Shen Li, Hector L. Franco   +2 more
openaire   +2 more sources

A novel Nodal enhancer dependent on pluripotency factors and Smad2/3 signaling conditions a regulatory switch during epiblast maturation [PDF]

, 2014
During early development, modulations in the expression of Nodal, a TGFβ family member, determine the specification of embryonic and extra-embryonic cell identities.
Jérôme Collignon (34631), Francina Langa (49327), Jérôme Collignon, Ataaillah Benhaddou (588226), Ataaillah Benhaddou, Costis Papanayotou, Valérie Mezger (588227), Délara Sabéran-Djoneidi (588228), Collignon, Jérôme, Aitana Perea-Gomez, Délara Sabéran-Djoneidi, Aitana Perea-Gomez (34627), Anne Camus (246751), Perea-Gomez, Aitana, Jouneau, Alice, Camus, Anne, Langa, Francina, Benhaddou, Ataaillah, Francina Langa, Sascha Ott, Anne Camus, Sabéran-Djoneidi, Délara, Alice Jouneau, Papanayotou, Costis, Costis Papanayotou (83558), Sascha Ott (192042), Alice Jouneau (328085), Ott, Sascha, Mezger, Valérie, Valérie Mezger, Ott Sascha, Perea-Gomez Aitana, Collignon Jérôme, Langa Francina, Mezger Valérie, Sabéran-Djoneidi Délara, Benhaddou Ataaillah, Camus Anne, Papanayotou Costis, Jouneau Alice   +39 more
core   +1 more source

Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

eLife, 2019
Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm ...
Jeehae Park, Javier Estrada, Gemma Johnson, Ben J Vincent, Chiara Ricci-Tam, Meghan DJ Bragdon, Yekaterina Shulgina, Anna Cha, Zeba Wunderlich, Jeremy Gunawardena, Angela H DePace   +10 more
doaj   +1 more source

Shared enhancer gene regulatory networks between wound and oncogenic programs

eLife, 2023
Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs, including apoptosis, proliferation, and cell migration ...
Swann Floc'hlay, Ramya Balaji, Dimitrije Stanković, Valerie M Christiaens, Carmen Bravo González-Blas, Seppe De Winter, Gert J Hulselmans, Maxime De Waegeneer, Xiaojiang Quan, Duygu Koldere, Mardelle Atkins, Georg Halder, Mirka Uhlirova, Anne-Kathrin Classen, Stein Aerts   +14 more
doaj   +1 more source