Results 21 to 30 of about 293,755 (268)
Frontiers in Immunology, 2018 The presence of abnormal gene expression signatures is a well-described feature of the oligoarticular and polyarticular forms of juvenile idiopathic arthritis.
Haeja Kessler +3 more
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Disparate expression specificities coded by a shared Hox-C enhancer
eLife, 2020 Can a single regulatory sequence be shared by two genes undergoing functional divergence? Here we describe a single promiscuous enhancer within the Drosophila Antennapedia Complex, EO053, that directs aspects of the expression of two adjacent genes, pb ...
Steve W Miller, James W Posakony
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eLife, 2019 Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm ...
Jeehae Park +10 more
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Shared enhancer gene regulatory networks between wound and oncogenic programs
eLife, 2023 Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs, including apoptosis, proliferation, and cell migration ...
Swann Floc'hlay +14 more
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Enhancers, enhancers – from their discovery to today’s universe of transcription enhancers [PDF]
Biological Chemistry, 2015 AbstractTranscriptional enhancers are short (200–1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes as key determinants of cell-
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Frontiers in Oncology, 2023 Breast cancer biology varies markedly among patients. Basal-like breast cancer is one of the most challenging subtypes to treat because it lacks effective therapeutic targets.
Kohei Kumegawa +4 more
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Frontiers in Physiology, 2021 Cardiac pacemaker cells differentiate and functionally specialize early in embryonic development through activation of critical gene regulatory networks.
Ravi Mandla +2 more
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Psychopharmaceutical Enhancers: Enhancing Identity? [PDF]
Neuroethics, 2009 The use of psychopharmaceuticals to enhance human mental functioning such as cognition and mood has raised a debate on questions regarding identity and authenticity. While some hold that psychopharmaceutical substances can help users to ‘become who they really are’ and thus strengthen their identity and authenticity, others believe that the substances ...
Bolt, Ineke, Schermer, Maartje
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The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of Medicine, 2019 The range of opportunities people enjoy in life largely depends on social, biological, and genetic factors for which individuals are not responsible. Philosophical debates about equality of opportunities have focussed mainly on addressing social determinants of inequalities.
Giubilini, A, Minerva, F
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From enhanced coinduction towards enhanced induction [PDF]
Proceedings of the ACM on Programming Languages, 2022 There exist a rich and well-developed theory of enhancements of the coinduction proof method, widely used on behavioural relations such as bisimilarity. We study how to develop an analogous theory for inductive behaviour relations, i.e., relations defined from inductive observables.
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