Results 11 to 20 of about 9,209,436 (353)
Cell, 2018 Summary Increased androgen receptor (AR) activity drives therapeutic resistance in advanced prostate cancer. The most common resistance mechanism is amplification of this locus presumably targeting the AR gene.
Sándor Spisak +2 more
exaly +2 more sources
Journal of Bioethical Inquiry, 2022 AbstractTransgender healthcare faces a dilemma. On the one hand, access to certain medical interventions, including hormone treatments or surgeries, where desired, may be beneficial or even vital for some gender dysphoric trans people. But on the other hand, access to medical interventions typically requires a diagnosis, which, in turn, seems to imply ...
Hazem Zohny +2 more
openaire +3 more sources
Molecular Therapy: Nucleic Acids, 2021 Glioma is the most common malignancy in the central nervous system with no immediate prospect of a cure. Comprehensive understanding on the pathogenesis of the disorder contributes to a better outcome.
Meixiong Cheng +5 more
doaj +1 more source
Enhancing Photorealism Enhancement
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2023 Code and data available at https://github.com/intel-isl/PhotorealismEnhancement Video available at https://youtu.be ...
Stephan R. Richter +2 more
openaire +3 more sources
Genome-wide enhancer maps link risk variants to disease genes
Nature, 2021 Genome-wide association studies (GWAS) have identified thousands of noncoding loci that are associated with human diseases and complex traits, each of which could reveal insights into the mechanisms of disease1. Many of the underlying causal variants may
J. Nasser +31 more
semanticscholar +1 more source
Nonlinear control of transcription through enhancer–promoter interactions
Nature, 2021 Chromosome structure in mammals is thought to regulate transcription by modulating three-dimensional interactions between enhancers and promoters, notably through CTCF-mediated loops and topologically associating domains (TADs)1–4.
J. Zuin +15 more
semanticscholar +1 more source
An encyclopedia of enhancer-gene regulatory interactions in the human genome
bioRxiv, 2023 Identifying transcriptional enhancers and their target genes is essential for understanding gene regulation and the impact of human genetic variation on disease1–6.
A. Gschwind +40 more
semanticscholar +1 more source
Autonomy and Enhancement [PDF]
Neuroethics, 2013 Some have objected to human enhancement on the grounds that it violates the autonomy of the enhanced. These objections, however, overlook the interesting possibility that autonomy itself could be enhanced. How, exactly, to enhance autonomy is a difficult problem due to the numerous and diverse accounts of autonomy in the literature.
Schaefer G.O., Kahane G., Savulescu J.
openaire +3 more sources
Mechanisms of enhancer action: the known and the unknown
Genome Biology, 2021 Differential gene expression mechanisms ensure cellular differentiation and plasticity to shape ontogenetic and phylogenetic diversity of cell types.
A. Panigrahi, B. O’Malley
semanticscholar +1 more source
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
Nature, 2021 The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodelling1 and is altered in over 20% of cancers2,3. Here we developed a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and ...
Lanbo Xiao +37 more
semanticscholar +1 more source