Results 11 to 20 of about 9,293,313 (313)
An encyclopedia of enhancer-gene regulatory interactions in the human genome
bioRxiv, 2023 Identifying transcriptional enhancers and their target genes is essential for understanding gene regulation and the impact of human genetic variation on disease1–6.
A. Gschwind +40 more
semanticscholar +1 more source
Mechanisms of enhancer action: the known and the unknown
Genome Biology, 2021 Differential gene expression mechanisms ensure cellular differentiation and plasticity to shape ontogenetic and phylogenetic diversity of cell types.
A. Panigrahi, B. O’Malley
semanticscholar +1 more source
Autonomy and Enhancement [PDF]
Neuroethics, 2013 Some have objected to human enhancement on the grounds that it violates the autonomy of the enhanced. These objections, however, overlook the interesting possibility that autonomy itself could be enhanced. How, exactly, to enhance autonomy is a difficult problem due to the numerous and diverse accounts of autonomy in the literature.
Schaefer G.O., Kahane G., Savulescu J.
openaire +3 more sources
Frontiers in Immunology, 2022 γδ T cells play important roles in immune responses by rapidly producing large quantities of cytokines. Recently, γδ T cells have been found to be involved in tissue homeostatic regulation, playing roles in thermogenesis, bone regeneration and synaptic ...
Alonso Rodríguez-Caparrós +6 more
doaj +1 more source
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
Nature, 2021 The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodelling1 and is altered in over 20% of cancers2,3. Here we developed a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and ...
Lanbo Xiao +37 more
semanticscholar +1 more source
Achievement and Enhancement [PDF]
Canadian Journal of Philosophy, 2019 AbstractWe engage with the nature and the value of achievement through a critical examination of an argument according to which biomedical “enhancement” of our capacities is impermissible because enhancing ourselves in this way would threaten our achievements. We call this the argument against enhancement from achievement.
Lisa Forsberg, Anthony Skelton
openaire +2 more sources
Frontiers in Genetics, 2020 The overall aim of the Ovine FAANG project is to provide a comprehensive annotation of the new highly contiguous sheep reference genome sequence (Oar rambouillet v1.0).
Mazdak Salavati +14 more
doaj +1 more source
Pterostilbene Changes Epigenetic Marks at Enhancer Regions of Oncogenes in Breast Cancer Cells
Antioxidants, 2021 Epigenetic aberrations are linked to sporadic breast cancer. Interestingly, certain dietary polyphenols with anti-cancer effects, such as pterostilbene (PTS), have been shown to regulate gene expression by altering epigenetic patterns.
Sadaf Harandi-Zadeh +11 more
doaj +1 more source
Compatibility rules of human enhancer and promoter sequences
Nature, 2022 Gene regulation in the human genome is controlled by distal enhancers that activate specific nearby promoters1. A proposed model for this specificity is that promoters have sequence-encoded preferences for certain enhancers, for example, mediated by ...
Drew T. Bergman +14 more
semanticscholar +1 more source
Frontiers in Genetics, 2021 Enhancers are regulatory DNA sequences that could be bound by specific proteins named transcription factors (TFs). The interactions between enhancers and TFs regulate specific genes by increasing the target gene expression.
Kun Niu +5 more
doaj +1 more source