Results 41 to 50 of about 9,209,436 (353)

Activity-by-Contact model of enhancer-promoter regulation from thousands of CRISPR perturbations

Nature Genetics, 2019
Enhancer elements in the human genome control how genes are expressed in specific cell types and harbor thousands of genetic variants that influence risk for common diseases1–4. Yet, we still do not know how enhancers regulate specific genes, and we lack
C. Fulco, J. Nasser, T. Jones, Glen Munson, Drew T. Bergman, V. Subramanian, S. Grossman, Rockwell Anyoha, Benjamin R. Doughty, Tejal A. Patwardhan, Tung H. Nguyen, Michael Kane, Elizabeth M. Perez, Neva C. Durand, C. Lareau, Elena K. Stamenova, Erez Lieberman Aiden, E. Lander, J. Engreitz   +18 more
semanticscholar   +1 more source

Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

eLife, 2019
Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm ...
Jeehae Park, Javier Estrada, Gemma Johnson, Ben J Vincent, Chiara Ricci-Tam, Meghan DJ Bragdon, Yekaterina Shulgina, Anna Cha, Zeba Wunderlich, Jeremy Gunawardena, Angela H DePace   +10 more
doaj   +1 more source

Shared enhancer gene regulatory networks between wound and oncogenic programs

eLife, 2023
Wound response programs are often activated during neoplastic growth in tumors. In both wound repair and tumor growth, cells respond to acute stress and balance the activation of multiple programs, including apoptosis, proliferation, and cell migration ...
Swann Floc'hlay, Ramya Balaji, Dimitrije Stanković, Valerie M Christiaens, Carmen Bravo González-Blas, Seppe De Winter, Gert J Hulselmans, Maxime De Waegeneer, Xiaojiang Quan, Duygu Koldere, Mardelle Atkins, Georg Halder, Mirka Uhlirova, Anne-Kathrin Classen, Stein Aerts   +14 more
doaj   +1 more source

Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion. [PDF]

, 2013
Serine recombinases are often tightly controlled by elaborate, topologically-defined, nucleoprotein complexes. Hin is a member of the DNA invertase subclass of serine recombinases that are regulated by a remote recombinational enhancer element containing
Chang, Yong, Dhar, Gautam, Heiss, John K, Johnson, Reid C, McLean, Meghan M   +4 more
core   +1 more source

FOXD1 is associated with poor outcome and maintains tumor-promoting enhancer–gene programs in basal-like breast cancer

Frontiers in Oncology, 2023
Breast cancer biology varies markedly among patients. Basal-like breast cancer is one of the most challenging subtypes to treat because it lacks effective therapeutic targets.
Kohei Kumegawa, Liying Yang, Kenichi Miyata, Reo Maruyama, Reo Maruyama   +4 more
doaj   +1 more source

The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]

, 1985
The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael, Calendar, R., Dorsch-Häsler, Karoline, Fleckenstein, Bernhard, Gold, L., Jahn, Gerhard, Rüger, Rüdiger, Schaffner, Walter, Stoerker, Jay, Weber, Frank   +9 more
core   +1 more source

Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial Node

Frontiers in Physiology, 2021
Cardiac pacemaker cells differentiate and functionally specialize early in embryonic development through activation of critical gene regulatory networks.
Ravi Mandla, Catherine Jung, Vasanth Vedantham   +2 more
doaj   +1 more source

Psychopharmaceutical Enhancers: Enhancing Identity? [PDF]

Neuroethics, 2009
The use of psychopharmaceuticals to enhance human mental functioning such as cognition and mood has raised a debate on questions regarding identity and authenticity. While some hold that psychopharmaceutical substances can help users to ‘become who they really are’ and thus strengthen their identity and authenticity, others believe that the substances ...
Bolt, Ineke, Schermer, Maartje
openaire   +2 more sources

Mapping the Shh long-range regulatory domain [PDF]

, 2014
Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms.
Amano, Belloni, Bickmore, Chuong, Davis, Dixon, Echelard, Epstein, Hecksher-Sorensen, Jeong, Jeong, Klopocki, Kokubu, Lettice, Lettice, Lettice, Lettice, Lettice, Lettice, Liu, Marinić, Mates, Montavon, Nagy, Niedermaier, Osoegawa, Paek, Riddle, Ruf, Sagai, Sagai, Sagai, Sharpe, Sharpe, Shen, Smallwood, Spitz, Sun, Symmons, Symmons, The ENCODE Consortium Project, Tsukiji   +41 more
core   +2 more sources

Enhancer grammar in development, evolution, and disease – dependencies and interplay

Developmental Cell, 2021
Each language has standard books describing that language’s grammatical rules. Biologists have searched for similar, albeit more complex, principles relating enhancer sequence to gene expression.
Granton A. Jindal, E. Farley
semanticscholar   +1 more source