Results 41 to 50 of about 9,293,313 (313)
Cell-specific expression of the FAP gene is regulated by enhancer elements
Frontiers in Molecular Biosciences, 2023 Fibroblast activation protein (FAP) is an integral membrane serine protease that acts as both dipeptidyl peptidase and collagenase. In recent years, FAP has attracted considerable attention due to its specific upregulation in multiple types of tumor cell
Dina V. Antonova +11 more
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Enhancer grammar in development, evolution, and disease – dependencies and interplay
Developmental Cell, 2021 Each language has standard books describing that language’s grammatical rules. Biologists have searched for similar, albeit more complex, principles relating enhancer sequence to gene expression.
Granton A. Jindal, E. Farley
semanticscholar +1 more source
YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Cell, 2017 SUMMARY There is considerable evidence that chromosome structure plays important roles in gene control, but we have limited understanding of the proteins that contribute to structural interactions between gene promoters and their enhancer elements. Large
A. Weintraub +15 more
semanticscholar +1 more source
Psychopharmaceutical Enhancers: Enhancing Identity? [PDF]
Neuroethics, 2009 The use of psychopharmaceuticals to enhance human mental functioning such as cognition and mood has raised a debate on questions regarding identity and authenticity. While some hold that psychopharmaceutical substances can help users to ‘become who they really are’ and thus strengthen their identity and authenticity, others believe that the substances ...
Bolt, Ineke, Schermer, Maartje
openaire +2 more sources
A SNP uncoupling Mina expression from the TGFβ signaling pathway
Immunity, Inflammation and Disease, 2018 Introduction Mina is a JmjC family 2‐oxoglutarate oxygenase with pleiotropic roles in cell proliferation, cancer, T cell differentiation, pulmonary inflammation, and intestinal parasite expulsion.
Shang L. Lian +4 more
doaj +1 more source
DIMETILSULFOKSID SEBAGAI ENHANCER TRANSPOR TRANSDERMAL TEOFILIN SEDIAAN GEL
Pharmaciana, 2013 Dimethylsulfoxide (DMSO) has been intensively studied the 19th century. This substance is used as a medicine and solve. It can also be used as an absorption enhancer of various drugs, either synthetical or herbal medicines.
Resty Annisa Damayanti, Tedjo Yuwono
doaj +1 more source
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
Cell, 2014 SUMMARY Macrophages are critical for innate immune defense and also control organ homeostasis in a tissue-specific manner. They provide a fitting model to study the impact of ontogeny and microenvironment on chromatin state and whether chromatin ...
Yonit Lavin +7 more
semanticscholar +1 more source
Frontiers in Immunology, 2019 CD8 expression in T lymphocytes is tightly regulated by the activity of at least six Cd8 enhancers (E8I-E8VI), however their complex developmental stage-, subset-, and lineage-specific interplays are incompletely understood.
Alexandra Franziska Gülich +9 more
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Targeted screening of genetic associations with COVID-19 susceptibility and severity
Frontiers in Genetics, 2022 The COVID-19 pandemic has resulted in great morbidity and mortality worldwide and human genetic factors have been implicated in the susceptibility and severity of COVID-19.
Ping Li +9 more
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Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
Nature Communications, 2020 Tissue-specific gene expression requires coordinated control of gene-proximal and -distal cis-regulatory elements (CREs), yet functional analysis of gene-distal CREs such as enhancers remains challenging.
Kailong Li +10 more
semanticscholar +1 more source