Results 51 to 60 of about 9,293,313 (313)

eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways

eLife, 2023
Cancer is driven by both genetic and epigenetic changes that impact on gene expression profiles and the resulting tumourigenic phenotype. Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring of gene ...
Ibrahim Ahmed, Shen-Hsi Yang, Samuel Ogden, Wei Zhang, Yaoyong Li, The OCCAMs consortium, Andrew D Sharrocks   +6 more
doaj   +1 more source

Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells

Genome Biology, 2020
H3K27ac is well recognized as a marker for active enhancers and a great indicator of enhancer activity. However, its functional impact on transcription has not been characterized.
Tiantian Zhang, Zhuqiang Zhang, Q. Dong, J. Xiong, Bing Zhu   +4 more
semanticscholar   +1 more source

REDfly: An Integrated Knowledgebase for Insect Regulatory Genomics

Insects, 2022
We provide here an updated description of the REDfly (Regulatory Element Database for Fly) database of transcriptional regulatory elements, a unique resource that provides regulatory annotation for the genome of Drosophila and other insects.
Soile V. E. Keränen, Angel Villahoz-Baleta, Andrew E. Bruno, Marc S. Halfon   +3 more
doaj   +1 more source

Increased Enhancer—Promoter Interactions during Developmental Enhancer Activation in Mammals

bioRxiv
Remote enhancers are thought to interact with their target promoters via physical proximity, yet the importance of this proximity for enhancer function remains unclear. Here, we investigate the 3D conformation of enhancers during mammalian development by
Zhuoxin Chen, V. Snetkova, Grace Bower, Sandra H. Jacinto, Benjamin Clock, Atrin Dizehchi, I. Barozzi, B. Mannion, Ana Alcaina-Caro, J. López-Ríos, D. Dickel, A. Visel, L. Pennacchio, Evgeny Z. Kvon   +13 more
semanticscholar   +1 more source

Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions

Cell, 2015
SUMMARY Mammalian genomes are organized into megabase-scale topologically associated domains (TADs). We demonstrate that disruption of TADs can rewire long-range regulatory architecture and result in pathogenic phenotypes.
D. Lupiáñez, K. Kraft, V. Heinrich, P. Krawitz, F. Brancati, E. Klopocki, D. Horn, H. Kayserili, John M. Opitz, R. Laxová, F. Santos-Simarro, B. Gilbert-Dussardier, L. Wittler, Marina Borschiwer, Stefan A. Haas, M. Osterwalder, Martin Franke, B. Timmermann, Jochen Hecht, M. Spielmann, A. Visel, S. Mundlos   +21 more
semanticscholar   +1 more source

HUBUNGAN POLA KONSUMSI SUMBER ZAT BESI, INHIBITOR DAN ENHANCER ZAT BESI DENGAN KEJADIAN ANEMIA PADA SANTRIWATI PONDOK PESANTREN AL-MIZAN MUHAMMADIYAH LAMONGAN
Correlation between consumption patterns of iron sources, iron inhibitor, and iron enhancer, with the occurence of anemia among female students in Islamic Boarding School Al-Mizan Muhammadiyah Lamongan

Media Gizi Indonesia, 2022
Anemia merupakan salah satu permasalahan defisiensi zat gizi yang rentan dialami oleh remaja putri. Anemia adalah kondisi dimana kadar hemoglobin (Hb) lebih rendah dari 12 g/dL. Anemia dapat disebabkan karena kekurangan darah, penyakit infeksi, rendahnya
Fanti Septia Nabilla, Lailatul Muniroh, Mahmud Aditya Rifqi   +2 more
doaj   +1 more source

Decoding regulatory associations of G-quadruplex with epigenetic and transcriptomic functional components

Frontiers in Genetics, 2022
G-quadruplex (G4) has been previously observed to be associated with gene expression. In this study, we performed integrative analysis on G4 multi-omics data from in-silicon prediction and ChIP-seq in human genome. Potential G4 sites were classified into
Shuyi Fang, Sheng Liu, Sheng Liu, Danzhou Yang, Danzhou Yang, Lei Yang, Lei Yang, Lei Yang, Chang-Deng Hu, Chang-Deng Hu, Jun Wan, Jun Wan, Jun Wan, Jun Wan   +13 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Genome-Wide Histone H3K27 Acetylation Profiling Identified Genes Correlated With Prognosis in Papillary Thyroid Carcinoma

Frontiers in Cell and Developmental Biology, 2021
Thyroid carcinoma (TC) is the most common endocrine malignancy, and papillary TC (PTC) is the most frequent subtype of TC, accounting for 85–90% of all the cases. Aberrant histone acetylation contributes to carcinogenesis by inducing the dysregulation of
Luyao Zhang, Dan Xiong, Qian Liu, Yiling Luo, Yuhan Tian, Xi Xiao, Ye Sang, Yihao Liu, Shubin Hong, Shuang Yu, Jie Li, Weiming Lv, Yanbing Li, Zhonghui Tang, Rengyun Liu, Qian Zhong, Haipeng Xiao   +16 more
doaj   +1 more source

Establishment and function of chromatin modification at enhancers [PDF]

Open Biology, 2020
How a single genome can give rise to distinct cell types remains a fundamental question in biology. Mammals are able to specify and maintain hundreds of cell fates by selectively activating unique subsets of their genome.
Amanuel Tafessu, Laura A. Banaszynski
doaj   +1 more source