Results 71 to 80 of about 9,209,436 (353)
Disruptions of Topological Chromatin Domains Cause Pathogenic Rewiring of Gene-Enhancer Interactions
Cell, 2015 SUMMARY Mammalian genomes are organized into megabase-scale topologically associated domains (TADs). We demonstrate that disruption of TADs can rewire long-range regulatory architecture and result in pathogenic phenotypes.
D. Lupiáñez +21 more
semanticscholar +1 more source
REDfly: An Integrated Knowledgebase for Insect Regulatory Genomics
Insects, 2022 We provide here an updated description of the REDfly (Regulatory Element Database for Fly) database of transcriptional regulatory elements, a unique resource that provides regulatory annotation for the genome of Drosophila and other insects.
Soile V. E. Keränen +3 more
doaj +1 more source
International Journal of Scientific and Research Publications (IJSRP), 2021 The Theory of Enhancement is a detailed theoretical research that presents the creative framework of the environment. It accounts for the formation of the universe taking into consideration all the laws and forces involved. The thread of this is the mathematical account of the enhancement of the nucleus.
openaire +1 more source
Media Gizi Indonesia, 2022 Anemia merupakan salah satu permasalahan defisiensi zat gizi yang rentan dialami oleh remaja putri. Anemia adalah kondisi dimana kadar hemoglobin (Hb) lebih rendah dari 12 g/dL. Anemia dapat disebabkan karena kekurangan darah, penyakit infeksi, rendahnya
Fanti Septia Nabilla +2 more
doaj +1 more source
Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data [PDF]
, 2013 Genome-wide association studies (GWASs) identify single nucleotide polymorphisms (SNPs) that are enriched in individuals suffering from a given disease. Most disease-associated SNPs fall into non-coding regions, so that it is not straightforward to infer
A Milosavljevic +57 more
core +6 more sources
Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences. [PDF]
, 2020 Hematopoietic stem cell gene therapy is a promising approach for treating disorders of the hematopoietic system. Identifying combinations of cis-regulatory elements that do not impede packaging or transduction efficiency when included in lentiviral ...
Aleshe, Bamidele +14 more
core +1 more source
Discriminating between viable and membrane-damaged cells of the plant pathogen Xylella fastidiosa. [PDF]
, 2019 Xylella fastidiosa is a plant pathogenic bacterium with devastating consequences to several crops of economic importance across the world. While this pathogen has been studied for over a century in the United States, several aspects of its biology remain
Almeida, Rodrigo +5 more
core +4 more sources
Frontiers in Genetics, 2022 G-quadruplex (G4) has been previously observed to be associated with gene expression. In this study, we performed integrative analysis on G4 multi-omics data from in-silicon prediction and ChIP-seq in human genome. Potential G4 sites were classified into
Shuyi Fang +13 more
doaj +1 more source
Reporter constructs with low background activity utilizing the cat gene [PDF]
, 1992 Reporter plasmids utilizing the cat gene for the analysis of promoter and enhancer sequences in vertebrate cells, were constructed. These plasmids minimize the background of transcription derived from cryptic promoters or cryptic regulatory elements ...
Andrea Schmidt +11 more
core +1 more source
, 2011 Der Mensch strebt seit Urzeiten danach, seine Möglichkeiten zu erweitern und seine Leistungsfähigkeit zu steigern. Mittel dazu reichen von den ersten Werkzeugen bis zur Computertechnik, von der Erfindung des Buchdrucks bis zum drahtlosen Internet. Zunehmend beobachtbar ist die Tendenz, dass gesunde Personen Wirkstoffe zu sich nehmen in der Hoffnung auf
Eckhardt, Anne +4 more
openaire +4 more sources