Results 71 to 80 of about 9,293,313 (313)

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos

Cell Genomics, 2022
Summary: DNA accessibility of cis-regulatory elements (CREs) dictates transcriptional activity and drives cell differentiation during development.
Alison C. McGarvey, Wolfgang Kopp, Dubravka Vučićević, Kenny Mattonet, Rieke Kempfer, Antje Hirsekorn, Ilija Bilić, Marine Gil, Alexandra Trinks, Anne Margarete Merks, Daniela Panáková, Ana Pombo, Altuna Akalin, Jan Philipp Junker, Didier Y.R. Stainier, David Garfield, Uwe Ohler, Scott Allen Lacadie   +17 more
doaj   +1 more source

Testing the super-enhancer concept

Nature reviews genetics, 2021
Many enhancers exist as clusters in the genome, which has led to the coining of the term ‘super-enhancer’. In this Viewpoint, five experts discuss our biological understanding of enhancer clusters, how we can responsibly study their functions, and their ...
G. Blobel, D. Higgs, Jennifer A. Mitchell, D. Notani, R. Young   +4 more
semanticscholar   +1 more source

Human Enhancement [PDF]

, 2011
Der Mensch strebt seit Urzeiten danach, seine Möglichkeiten zu erweitern und seine Leistungsfähigkeit zu steigern. Mittel dazu reichen von den ersten Werkzeugen bis zur Computertechnik, von der Erfindung des Buchdrucks bis zum drahtlosen Internet. Zunehmend beobachtbar ist die Tendenz, dass gesunde Personen Wirkstoffe zu sich nehmen in der Hoffnung auf
Eckhardt, Anne, Bachmann, Andreas, Marti, Michèle, Rütsche, Bernhard, Telser, Harry   +4 more
openaire   +4 more sources

Psychosocial Functioning After Pediatric Bone Sarcoma: Generic and Survivor‐Specific Outcomes in Adolescent and Young Adult Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric bone sarcoma patients and survivors may experience psychosocial challenges related to childhood cancer after their intensive, body‐altering treatment. This cross‐sectional study aimed to evaluate generic and survivor‐specific psychosocial outcomes in a national cohort of pediatric bone sarcoma patients and survivors, and ...
Hinke van der Hoek, Heleen Maurice‐Stam, Laura R. Beek, Jennifer van Dijk, Marjolein E. M. Langemeijer, Relinde W. Slooff‐Lentink, Alied M. van der Aa‐van Delden, Anne Westerweel, Marloes van Gorp, Hendrik W. B. Schreuder, Lianne M. Haveman, W. Peter Bekkering, Leonie G. Tigelaar, Johannes H. M. Merks, Martha A. Grootenhuis   +14 more
wiley   +1 more source

Ironic Medications: A Narrative‐Based Psycho‐Educational Intervention to Explore Patient–Provider Communication in Adolescents With Haematological Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with haematological malignancies face significant emotional and relational challenges, often accompanied by difficulties in communicating their needs within the healthcare context. To address these issues, a narrative‐based psycho‐educational intervention based on the creation and prescription of Ironic Medications was ...
Marta Stoppa, Elena Pagani Bagliacca, Selena Russo, Giulia Rampoldi, Maria Grazia Strepparava, Adriana Cristina Balduzzi, Andrea Biondi, Marco Spinelli   +7 more
wiley   +1 more source

Identification of novel prognostic biomarkers in the TF-enhancer-target regulatory network in hepatocellular carcinoma and immune infiltration analysis

Frontiers in Genetics, 2023
Background: Hepatocellular carcinoma (HCC) remains notorious for its high malignancy, poor prognosis and high mortality. The exploration of novel therapeutic agents for HCC has remained challenging due to its complex aetiology. Therefore, it is necessary
Jianing Yan, Jianing Yan, Guoliang Ye, Guoliang Ye, Yongfu Shao, Yongfu Shao, Hanxuan Zhou   +6 more
doaj   +1 more source

Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly

Nature Structural & Molecular Biology, 2019
A crucial feature of differentiated cells is the rapid activation of enhancer-driven transcriptional programs in response to signals. The potential contributions of physicochemical properties of enhancer assembly in signaling events remain poorly ...
Sreejith J. Nair, Lu Yang, Dario Meluzzi, Soohwan Oh, Feng Yang, Meyer J. Friedman, Susan Wang, Tom Suter, Ibraheem Alshareedah, A. Gamliel, Qi Ma, Jie Zhang, Yi-ren Hu, Yuliang Tan, K. Ohgi, R. Jayani, Priya R Banerjee, A. Aggarwal, M. Rosenfeld   +18 more
semanticscholar   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

Interallelic Transcriptional Enhancement as an in Vivo Measure of Transvection in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2016
Transvection—pairing-dependent interallelic regulation resulting from enhancer action in trans—occurs throughout the Drosophila melanogaster genome, likely as a result of the extensive somatic homolog pairing seen in Dipteran species.
Geoffrey P. Noble, Patrick J. Dolph, Surachai Supattapone   +2 more
doaj   +1 more source

Krüppel‐Like Factors Orchestrate Endothelial Gene Expression Through Redundant and Non‐Redundant Enhancer Networks

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Proper function of endothelial cells is critical for vascular integrity and organismal survival. Studies over the past 2 decades have identified 2 members of the KLF (Krüppel‐like factor) family of proteins, KLF2 and KLF4, as nodal regulators ...
David R. Sweet, Roshan Padmanabhan, Xudong Liao, Himanshu R. Dashora, Xinmiao Tang, Lalitha Nayak, Rajan Jain, Sarah De Val, Vinesh Vinayachandran, Mukesh K. Jain   +9 more
doaj   +1 more source