Results 91 to 100 of about 9,293,313 (313)
Prodrug Strategies for Enhancing the Percutaneous Absorption of Drugs
Molecules, 2014 The transdermal application of drugs has attracted increasing interest over the last decade or so, due to the advantages it offers, compared to other delivery methods.
David D. N'Da
doaj +1 more source
AttnW2V-Enhancer: Leveraging attention and Word2Vec for enhanced enhancer prediction
Computational and Structural Biotechnology JournalAccurate identification of enhancer regions in DNA sequences is essential for understanding gene regulation and its role in diverse biological processes. Enhancers are regulatory elements that influence gene expression, but their detection remains challenging due to the complexity and variability of genomic sequences.
Rehman, Mobeen Ur +3 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger +8 more
wiley +1 more source
Expanded Insights Into Mechanisms of Gene Expression and Disease Related Disruptions
Frontiers in Molecular Biosciences, 2018 Definitive molecular diagnoses in disorders apparently due to genetic or genomic defects are still lacking in a significant number of investigated cases, despite use of studies designed to discover defects in the protein coding regions of the genome ...
Moyra Smith, Pamela L. Flodman
doaj +1 more source
Long non-coding RNAs with enhancer-like function in human
Cell, 2010 While the long non-coding RNAs (ncRNAs) constitute a large portion of the mammalian transcriptome, their biological functions has remained elusive. A few long ncRNAs that have been studied in any detail silence gene expression in processes such as X ...
U. A. Ørom +11 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neurodevelopmental and neurocognitive difficulties are prevalent among individuals with sickle cell disease and warrant prompt identification and support. This Special Report provides an executive summary of standards and recommendations for surveillance, screening, and evaluation for development and cognition across the lifespan developed by ...
Alyssa M. Schlenz +12 more
wiley +1 more source
Enhancer control of transcriptional bursting
Cell, 2016 Summary Transcription is episodic, consisting of a series of discontinuous bursts. Using live imaging methods and quantitative analysis, we examine transcriptional bursting in living Drosophila embryos.
Takashi Fukaya, Bomyi Lim, M. Levine
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior +11 more
wiley +1 more source
Dynamic interplay between enhancer-promoter topology and gene activity
Nature Genetics, 2018 A long-standing question in gene regulation is how remote enhancers communicate with their target promoters, and specifically how chromatin topology dynamically relates to gene activation.
Hongtao Chen +5 more
semanticscholar +1 more source
Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source