Results 91 to 100 of about 9,209,436 (353)

Genome-Wide Histone Modifications and CTCF Enrichment Predict Gene Expression in Sheep Macrophages

Frontiers in Genetics, 2021
Alveolar macrophages function in innate and adaptive immunity, wound healing, and homeostasis in the lungs dependent on tissue-specific gene expression under epigenetic regulation.
Alisha T. Massa, Michelle R. Mousel, Michelle R. Mousel, Maria K. Herndon, David R. Herndon, Brenda M. Murdoch, Brenda M. Murdoch, Stephen N. White, Stephen N. White, Stephen N. White   +9 more
doaj   +1 more source

Identification of a Chondrocyte-Specific Enhancer in the Hoxc8 Gene

Journal of Developmental Biology
Hox genes encode transcription factors whose roles in patterning animal body plans during embryonic development are well-documented. Multiple studies demonstrate that Hox genes continue to act in adult cells, in normal differentiation, in regenerative ...
Stephania A. Cormier, Claudia Kappen
doaj   +1 more source

ZPA Regulatory Sequence Variants in Chinese Patients With Preaxial Polydactyly: Genetic and Clinical Characteristics

Frontiers in Pediatrics, 2022
Preaxial polydactyly (PPD) is a common congenital abnormality with an incidence of 0.8–1.4% in Asians, characterized by the presence of extra digit(s) on the preaxial side of the hand or foot.
Lei Zeng, Jie-Yuan Jin, Jie-Yuan Jin, Fang-Mei Luo, Fang-Mei Luo, Yue Sheng, Pan-Feng Wu, Pan-Feng Wu, Rong Xiang, Rong Xiang, Rong Xiang, Rong Xiang   +11 more
doaj   +1 more source

Large-scale discovery of enhancers from human heart tissue. [PDF]

, 2011
Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers.
Afzal, Veena, Akiyama, Jennifer A, Black, Brian L, Blow, Matthew J, Bristow, James, Holt, Amy, Jensen, Brian C, Kaplan, Tommy, May, Dalit, McCulley, David J, Pennacchio, Len A, Plajzer-Frick, Ingrid, Rubin, Edward M, Shoukry, Malak, Simpson, Paul C, Visel, Axel, Wright, Crystal   +16 more
core  

Extinction of gene expression in somatic cell hybrids. a reflection of important regulatory mechanisms? [PDF]

, 1993
Extinction in somatic cell hybrids is a multifactorial process that leads to loss of cell-type-specific gene expression. The underlying mechanisms are thought to mirror, at least in part, the repertoire of regulatory mechanisms controlling mammalian cell
Boshart, Michael, Nitsch, Doris, Schütz, Günther   +2 more
core   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Endogenous retroviral solo-LTRs in human genome

Frontiers in Genetics
Human endogenous retroviruses (HERVs) are derived from the infection and integration of exogenetic retroviruses. HERVs account for 8% of human genome, and the majority of HERVs are solitary LTRs (solo-LTRs) due to homologous recombination.
Mingyue Chen, Xiaolong Huang, Chunlei Wang, Chunlei Wang, Chunlei Wang, Shibo Wang, Lei Jia, Lei Jia, Lin Li, Lin Li   +9 more
doaj   +1 more source

Single-cell-resolved dynamics of chromatin architecture delineate cell and regulatory states in zebrafish embryos

Cell Genomics, 2022
Summary: DNA accessibility of cis-regulatory elements (CREs) dictates transcriptional activity and drives cell differentiation during development.
Alison C. McGarvey, Wolfgang Kopp, Dubravka Vučićević, Kenny Mattonet, Rieke Kempfer, Antje Hirsekorn, Ilija Bilić, Marine Gil, Alexandra Trinks, Anne Margarete Merks, Daniela Panáková, Ana Pombo, Altuna Akalin, Jan Philipp Junker, Didier Y.R. Stainier, David Garfield, Uwe Ohler, Scott Allen Lacadie   +17 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]

, 1994
Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core   +2 more sources