Results 111 to 120 of about 370,708 (316)

Mechanisms of enhancer-driven oncogene activation [PDF]

An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there ...
Pastoors, Dorien, Delwel, Ruud, Vriend, Joyce   +2 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Summary of enhancer analysis.

, 2015
Summary of enhancer analysis.
Enrico D’Aniello (798447), Padmapriyadarshini Ravisankar (798448), Joshua S. Waxman (443499)   +2 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A transcribed enhancer dictates mesendoderm specification in pluripotency [PDF]

, 2017
Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome during mesendoderm specification.
Marco Mina, Ibberson, M., Plaisance, Isabelle, Ounzain, S., Leib, S.L., Burdet, Frédéric, Kernen, Jasmin, Alexanian, Michael, Maric, D., Friedman, C.E., Nemir, Mohamed, Jenkinson, S.P., Micheletti, R., Alexanian, M., Villeneuve, D., Villeneuve, Dominic, Pedrazzini, T., Ching-Chia Ting, Damien Maison, Thierry Pedrazzini, Nemir, M., Mina, M., Clayton E. Friedman, Iole Pezzuto, Ounzain, Samir, Hernandez, Nouria, Stephen P. Jenkinson, Maric, Daniel, Daniel Maric, Maison, D., Kernen, J., Ting, Ching-Chia, Mark Ibberson, Pedrazzini, Thierry, Nathan J. Palpant, Burdet, F., Plaisance, I., Pezzuto, Iole, Pezzuto, I., Stephen L. Leib, Nouria Hernandez, Maison, Damien, Leib, Stephen, Mohamed Nemir, Frédéric Burdet, Mina, Marco, Ibberson, Mark, Ting, C.C., Samir Ounzain, Rudi Micheletti, Jasmin Kernen, Palpant, Nathan J., Jenkinson, Stephen Philip, Micheletti, Rudi, Isabelle Plaisance, Dominic Villeneuve, Palpant, N.J., Michael Alexanian, Friedman, Clayton E., Hernandez, N., Burdet F, Maison D, Pezzuto I, Villeneuve D, Pedrazzini T, Mina M, Nemir M, Maric D, Micheletti R, Ting CC, Palpant NJ, Plaisance I, Ounzain S, Friedman CE, Kernen J, Leib SL, Hernandez N, Ibberson M, Alexanian M, Jenkinson SP   +79 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Evaluating promoter and enhancer specificity to determine optimum transgenic construc configuration for enhancer characterization.

, 2013
Evaluating promoter and enhancer specificity to determine optimum transgenic construc configuration for enhancer characterization.
Gabriela G. Loots (9841), Anne Bergmann (433903), Ivan Ovcharenko (9842), Catherine E. Oldenburg (433905), Na Hu (115586), Andrea E. Wills (433906), Nicholas R. Hum (433904), Richard M. Harland (433907)   +7 more
core   +1 more source