Results 111 to 120 of about 9,209,436 (353)
Long non-coding RNAs with enhancer-like function in human
Cell, 2010 While the long non-coding RNAs (ncRNAs) constitute a large portion of the mammalian transcriptome, their biological functions has remained elusive. A few long ncRNAs that have been studied in any detail silence gene expression in processes such as X ...
U. A. Ørom +11 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee +9 more
wiley +1 more source
Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells. [PDF]
, 2017 Endothelial cells (ECs) are critical determinants of vascular homeostasis and inflammation, but transcriptional mechanisms specifying their identities and functional states remain poorly understood.
Glass, Christopher K +7 more
core +2 more sources
Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek +13 more
wiley +1 more source
Advanced ScienceDuring the formation of kidney stones, the interaction between crystals and tubular epithelial cells (TECs) leads to tubular injury and dysfunction, which in turn promote stone formation. However, the molecular mechanisms underlying these changes in TECs
Yu Yang +12 more
doaj +1 more source
MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1 [PDF]
, 2016 Congenital heart defects are the most common birth defects in humans, and those that affect the proper alignment of the outflow tracts and septation of the ventricles are a highly significant cause of morbidity and mortality in infants.
Barnes, Ralston M. +9 more
core +1 more source
Enhancer control of transcriptional bursting
Cell, 2016 Summary Transcription is episodic, consisting of a series of discontinuous bursts. Using live imaging methods and quantitative analysis, we examine transcriptional bursting in living Drosophila embryos.
Takashi Fukaya, Bomyi Lim, M. Levine
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long‐term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during ...
Anna Maria Markarian +7 more
wiley +1 more source
Prodrug Strategies for Enhancing the Percutaneous Absorption of Drugs
Molecules, 2014 The transdermal application of drugs has attracted increasing interest over the last decade or so, due to the advantages it offers, compared to other delivery methods.
David D. N'Da
doaj +1 more source
Dynamic interplay between enhancer-promoter topology and gene activity
Nature Genetics, 2018 A long-standing question in gene regulation is how remote enhancers communicate with their target promoters, and specifically how chromatin topology dynamically relates to gene activation.
Hongtao Chen +5 more
semanticscholar +1 more source