Results 121 to 130 of about 370,708 (316)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Image Enhancer Code Metric

, 2014
Image Enhancer 1.0.0 Release Candidate Code ...
Abhisek Hazra (474500)
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Identification and characterization of two critical sequences in SV40PolyA that activate the green fluorescent protein reporter gene

Genetics and Molecular Biology, 2011
Alu repeats or Line-1-ORF2 (ORF2) inhibit expression of the green fluorescent protein (GFP) gene when inserted downstream of this gene in the vector pEGFP-C1.
Honggang Wang, Wuzhuang Sun, Zhu Li, Xiufang Wang, Zhanjun Lv   +4 more
doaj  

Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury

, 2020
Acute kidney injury is a major health problem amongst hospitalized patients. Here the authors provide a comprehensive characterization of enhancer and super-enhancer elements, and the transcription factor motifs associated with these elements in response
Lothar Hennighausen, Jakub Jankowski, Takaharu Ichimura, Michaela Willi, Hannes Olauson, Hye Kyung Lee, Julia Wilflingseder, Reinhold Erben, M. Todd Valerius, Joseph V. Bonventre, Willi, M, Valerius, MT, Bonventre, JV, Jankowski, J, Olauson, H,, Wilflingseder, J, Ichimura, T, Erben, R, Hennighausen, L, Lee, HK   +19 more
core   +1 more source

Mapping the Shh long-range regulatory domain [PDF]

, 2014
Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms.
Hill, Robert E, Devenney, Paul S, Lettice, Laura A, Anderson, Eve   +3 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Enhancer screen image files

, 2019
raw images associated with in vivo tests of enhancer ...
Grayson, Phil, Gardner, Paul P., Clamp, Michele, Hu, Zhirui, Liu, Jun S., Baker, Allan J., Cloutier, Alison, Wheeler, Nicole E., Clarke, Julia A., Edwards, Scott V., Sackton, Timothy B.   +10 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The enhancer H3.3 nucleosomes display higher splitting index than the non-enhancer H3.3 nucleosomes.

, 2013
(A) Box plot of the splitting index of enhancer or non-enhancer H3.3 nucleosomes within the same turnover ranges. (B) Box plot of the splitting index of H3.3 nucleosomes at the enhancers, promoters, 5-UTRs within the same turnover ranges.
Mo Xu (418704), Yingfeng Li (418705), Chang Huang (418702), Yanting Ma (418706), Zhuqiang Zhang (418703), Zhen Li (49109), Tao Cai (19539), Bing Zhu (145649)   +7 more
core   +1 more source