Results 121 to 130 of about 9,209,436 (353)

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Expanded Insights Into Mechanisms of Gene Expression and Disease Related Disruptions

Frontiers in Molecular Biosciences, 2018
Definitive molecular diagnoses in disorders apparently due to genetic or genomic defects are still lacking in a significant number of investigated cases, despite use of studies designed to discover defects in the protein coding regions of the genome ...
Moyra Smith, Pamela L. Flodman
doaj   +1 more source

A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number [PDF]

, 2013
Motivation: cis-regulatory DNA sequence elements, such as enhancers and silencers, function to control the spatial and temporal expression of their target genes.
Ashall, Bärbel Finkenstädt, Dan J. Woodcock, David, David A. Rand, Downey, Elf, Elowitz, Finkenstädt, Georgy Koentges, Harper, Heron, Ingram, Jeziorska, Jeziorska, Keith W. Vance, Komorowski, MacKenzie, Marsaglia, Melnikov, Michał Komorowski, Odelberg, Patwardhan, Paulsson, Paulsson, Sharon, Suter   +26 more
core   +3 more sources

Systematic mapping of functional enhancer-promoter connections with CRISPR interference

Science, 2016
CRISPR screens illuminate enhancer function The noncoding regions around a gene that control the transcription of the protein-coding region are difficult to identify. Leveraging a CRISPR interference system (CRISPRi), Fulco et al.
C. Fulco, Mathias Munschauer, Rockwell Anyoha, Glen Munson, S. Grossman, Elizabeth M. Perez, Michael Kane, B. Cleary, E. Lander, J. Engreitz   +9 more
semanticscholar   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Modification of enhancer chromatin: what, how and why?

Molecules and Cells, 2013
Emergence of form and function during embryogenesis arises in large part through cell type- and cell state- specific variation in gene expression patterns, mediated by specialized cis-regulatory elements called enhancers.
Eliezer Calo, J. Wysocka
semanticscholar   +1 more source

Assessing Cognitive Functioning in Children With Brain Tumors: Interaction of Neighborhood Social Determinants of Health and Neurological Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background This study investigated how neighborhood‐level social determinants of health (SDOH), including redlining and neurological risk, interact to influence cognitive outcomes in children treated for brain tumors (CTBT). Methods A retrospective chart review of 161 CTBT aged 5–17 was conducted.
Alannah R. Srsich, Manali Zope, Peter M. Fantozzi, Cassie N. Kline, Iris Paltin, Matthew C. Hocking   +5 more
wiley   +1 more source

AttnW2V-Enhancer: Leveraging attention and Word2Vec for enhanced enhancer prediction

Computational and Structural Biotechnology Journal
Accurate identification of enhancer regions in DNA sequences is essential for understanding gene regulation and its role in diverse biological processes. Enhancers are regulatory elements that influence gene expression, but their detection remains challenging due to the complexity and variability of genomic sequences.
Mobeen Ur Rehman, Zeeshan Abbas, Farman Ullah, Irfan Hussain   +3 more
openaire   +3 more sources

HPA* Enhancements

Proceedings of the AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment, 2007
In video games, pathfinding must be done quickly and accurately. Not much computational time is allowed for pathfinding, but realistic looking paths are required. One approach to pathfinding which attempts to satisfy both of these constraints is to perform pathfinding on abstractions of the map.
M. Renee Jansen, Michael Buro
openaire   +2 more sources