Results 21 to 30 of about 390,492 (308)

Identification of Minimal p53 Promoter Region Regulated by MALAT1 in Human Lung Adenocarcinoma Cells

open access: yesFrontiers in Genetics, 2018
The MALAT1 long noncoding RNA is strongly linked to cancer progression. Here we report a MALAT1 function in repressing the promoter of p53 (TP53) tumor suppressor gene.
Keiko Tano   +6 more
doaj   +1 more source

Polimorfismos en el gen promotor de IL-10 en una muestra de pacientes colombianos con lepra

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2012
Introducción. Se han reportado polimorfismos en los genes promotores que codifican para citocinas y que afectan los niveles de transcripción, con implicaciones clínicas y funcionales en pacientes con lepra. Objetivo.
Nora Cardona-Castro   +3 more
doaj   +1 more source

Functional analysis of human and chimpanzee promoters [PDF]

open access: yes, 2005
Background: It has long been argued that changes in gene expression may provide an additional and crucial perspective on the evolutionary differences between humans and chimpanzees.
Philipp Khaitovich   +21 more
core   +1 more source

Comparative analysis on the structural features of the 5' flanking region of kappa-casein genes from six different species [PDF]

open access: yes, 2002
Kappa-casein plays an essential role in the formation, stabilisation and aggregation of milk micelles. Control of kappa-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other ...
C. Bruce A. Whitelaw,   +16 more
core   +1 more source

Stress-induced duplex destabilization (SIDD) profiles for T7 bacteriophage promoters [PDF]

open access: yesКомпьютерные исследования и моделирование, 2018
The functioning of DNA regulatory regions rely primarily on their physicochemical and structural properties but not on nucleotide sequences, i.e. genetic text.
Mikhail Anatolievich Orlov   +4 more
doaj   +1 more source

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]

open access: yes, 2011
Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone   +35 more
core   +1 more source

Genetic analysis of the dsz promoter and associated regulatory regions of Rhodococcus erythropolis IGTS8 [PDF]

open access: yesJournal of Bacteriology, 1996
The dsz gene cluster of Rhodococcus erythropolis IGTS8 comprises three genes, dszA, dszB, and dszC, whose products are involved in the conversion of dibenzothiophene (DBT) to 2-hydroxybiphenyl and sulfite. This organism can use DBT as the sole sulfur source but not as a carbon source.
M Z, Li   +3 more
openaire   +2 more sources

Molecular Profiling of DNA Methylation and Alternative Splicing of Genes in Skeletal Muscle of Obese Rabbits

open access: yesCurrent Issues in Molecular Biology, 2021
DNA methylation and the alternative splicing of precursor messenger RNAs (pre-mRNAs) are two important genetic modification mechanisms. However, both are currently uncharacterized in the muscle metabolism of rabbits. Thus, we constructed the Tianfu black
Yanhong Li   +10 more
doaj   +1 more source

Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers [PDF]

open access: yesOxidative Medicine and Cellular Longevity, 2020
The genetic polymorphism in the nuclear factor erythroid 2-related factor 2 (Nrf2) gene has been reported as one of the prognosis markers for various diseases, including cancer. Nrf2 is a key transcription factor involved in wound healing by regulating angiogenesis.
Rajan Teena   +4 more
openaire   +2 more sources

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression [PDF]

open access: yes, 2013
Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the ...
Hayes, R B   +361 more
core   +1 more source

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