Results 11 to 20 of about 4,748,947 (305)

SNP@Promoter: a database of human SNPs (Single Nucleotide Polymorphisms) within the putative promoter regions [PDF]

BMC Bioinformatics, 2008
Background Analysis of single nucleotide polymorphism (SNP) is becoming a key research in genomics fields. Many functional analyses of SNPs have been carried out for coding regions and splicing sites that can alter proteins and mRNA splicing.
Chung Won-Hyong, Park Daeui, Kim Woo-Yeon, Kim Byoung-Chul, Shin Kwang-sik, Bhak Jong   +5 more
doaj   +2 more sources

Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi [PDF]

BMC Gastroenterology, 2006
Background Hepatitis B virus (HBV) genotypes have distinct geographic distribution. Moreover, much genetic variability has been described in the precore (PC) and basal core promoter (BCP) regions of the HBV genome.
Naqvi Syed, Siddiqui Arif, Muzaffar Rana, Abbas Zaigham, Rizvi Syed   +4 more
doaj   +3 more sources

Genetic effect of an InDel in the promoter region of the NUDT15 and its effect on myoblast proliferation in chickens [PDF]

BMC Genomics, 2022
Abstract Background Molecular breeding accelerates the speed of animal breeding. Screening molecular markers that can affect economic traits through genome-wide association studies (GWAS) can provide a theoretical basis for molecular breeding.
Chengjie Wei, Yufang Niu, Bingjie Chen, Panpan Qin, Yanxing Wang, Dan Hou, Tong Li, Ruiting Li, Chunxiu Wang, Huadong Yin, Ruili Han, Huifen Xu, Yadong Tian, Xiaojun Liu, Xiangtao Kang, Zhuanjian Li   +15 more
openaire   +3 more sources

Genetic variant in theHSPB1 promoter region impairs the HSP27 stress response [PDF]

Human Mutation, 2007
The 27 kDa heat shock protein 1 (HSP27) is a member of the ubiquitously expressed small heat shock protein family and has pleiotropic cytoprotective functions. Since HSP27 may act as a motor neuron survival factor, we analyzed the genetic contribution of the human HSPB1 gene (HSPB1) to the etiology of amyotrophic lateral sclerosis (ALS). In a cohort of
Dierick, Ines, Irobi, Joy, Janssens, Sophie, Theuns, Jessie, Lemmens, Robin, Jacobs, An, Corsmit, Ellen, Hersmus, Nicole, van den Bosch, Ludo, Robberecht, Wim, De Jonghe, Peter, Van Broeckhoven, Christine, Timmerman, Vincent   +12 more
openaire   +3 more sources

Clinical Implications of Genetic Variation in the Serotonin Transporter Promoter Region [PDF]

The Primary Care Companion to The Journal of Clinical Psychiatry, 2009
To determine the state of the art in understanding the role of genetic variation in the serotonin transporter (5-HTT) promoter region (5-HTTLPR) in the development of a depressive episode and in its response to treatment.PubMed and Ovid were used to search for articles published prior to December 2007 utilizing the key words serotonin transporter, 5 ...
Nicole S, Luddington, Anitha, Mandadapu, Margaret, Husk, Rif S, El-Mallakh   +3 more
openaire   +2 more sources

Genetic analysis of the promoter region of the Bacillus subtilis alpha-amylase gene [PDF]

Journal of Bacteriology, 1989
The amyR2 allele of the Bacillus subtilis alpha-amylase cis-regulatory region enhances production of amylase and transcription of amyE, the structural gene, by two- to threefold over amyR1. The amylase gene bearing each of these alleles was cloned on plasmids of about 10 to 15 copies per chromosome. Transcription of the cloned amylase gene by each amyR
M J, Weickert, G H, Chambliss
openaire   +2 more sources

Detection of rare genetic variations in the promoter regions of the ATG16L gene in Parkinson's patients

Neuroscience Letters, 2023
Mutations in the ATG genes have been related to impair autophagic function, contributing to the sporadic onset of Parkinsońs Disease (PD). However, scarce studies have been performed about ins/del within the regulatory domains of the autophagy genes in sporadic PD patients. This study was aimed to found ins/del within part of the crucial core autophagy
A, Gómez-Martín, José M, Fuentes, J, Jordán, M F, Galindo, José L, Fernández-García   +4 more
openaire   +2 more sources

Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer [PDF]

BioMed Research International, 2017
Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer. Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer. However, the roles of miR-10b-related
Jiaping Chen, Yue Jiang, Jing Zhou, Sijun Liu, Yayun Gu, Guangfu Jin, Zhibin Hu, Hongxia Ma, Hongbing Shen, Juncheng Dai   +9 more
openaire   +2 more sources

Transcriptional analysis of the human PAX9 promoter

Journal of Applied Oral Science, 2010
OBJECTIVES: PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural crest-derived mesenchyme.
Carolina Vieira de Almeida, Simone Caixeta de Andrade, Cristiane Pereira Borges Saito, Liza Lima Ramenzoni, Sergio Roberto Peres Line   +4 more
doaj   +1 more source

Functional analysis of recurrent CDC20 promoter variants in human melanoma

Communications Biology, 2023
Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks.
Paula M. Godoy, Abimbola Oyedeji, Jacqueline L. Mudd, Vasilios A. Morikis, Anna P. Zarov, Gregory D. Longmore, Ryan C. Fields, Charles K. Kaufman   +7 more
doaj   +1 more source