Results 71 to 80 of about 390,492 (308)

Functional and genetic characterization of the promoter region of apolipoprotein H (β₂‐glycoprotein I) [PDF]

The FEBS Journal, 2010
This study characterized the human apolipoprotein H [APOH; β2‐glycoprotein I (β2GPI)] promoter and its variants by in vitro functional experiments and investigated their relationship with human plasma β2GPI levels. We examined the individual effects of 12 APOH promoter single nucleotide polymorphisms in the 5′ flanking region of APOH (∼ 1.4 kb) on ...
Sangita, Suresh, F Yesim, Demirci, Iliya, Lefterov, Candace M, Kammerer, Rosalind, Ramsey-Goldman, Susan, Manzi, M Ilyas, Kamboh   +6 more
openaire   +2 more sources

Association Between Promoter Polymorphisms in CD46 and CD59 in Kidney Donors and Transplant Outcome

Frontiers in Immunology, 2018
Complement regulating proteins, including CD46, CD55, and CD59, protect cells against self-damage. Because of their expression on the donor endothelium, they are hypothesized to be involved in accommodation.
Laura A. Michielsen, Arjan D. van Zuilen, Tineke Kardol-Hoefnagel, Marianne C. Verhaar, Henny G. Otten   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Examination of the brassica napus β-Keto-Acyl carrier protein reductase promoter for regulatory Cis-acting elements [PDF]

, 2002
Major interest has focused on the identification of regulatory factors involved in lipid biosynthesis. This study examined the B.napus β-Keto-ACP reductase 5' sequence for potential regulatory cis-acting elements.
Young, Clare Elisabeth
core  

CadC-mediated activation of the cadBA promoter in Escherichia coli [PDF]

, 2005
The transcriptional activator CadC in Escherichia coli, a member of the ToxR-like proteins, activates transcription of the cadBA operon encoding the lysine decarboxylase CadA and the lysine-cadaverine antiporter CadB. cadBA is induced under conditions of
Kuper, C., Jung, K.
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia

, 2015
Although children with acute lymphoblastic leukemia (ALL) generally have a good outcome, some patients do relapse and survival following relapse is poor.
Mitchell, Chris D, Steven C Clifford (779057), Gabriel, Alem, Clifford, Steven, Schwalbe, Edward C, Mitchell, Chris, Nakjang, Sirintra, Alem S Gabriel (779049), Clifford, Steven C, Lafta, Fadhel M, Strathdee, Gordon, Simon J Cockell (779052), Kinsey, Sally, Vikki Rand (779056), Iliasova, Alice, Christine J Harrison (779061), Schwalbe, Ed, Harrison, Christine, Anthony V Moorman (779062), Lafta, Fadhel, Kinsey, Sally E, Sally E Kinsey (779058), Chris D Mitchell (779059), Vora, Ajay, Cockell, Simon J, Rand, Vikki, Edward C Schwalbe (779051), Gordon Strathdee (779063), Enshaei, Amir, Sirintra Nakjang (124590), Harris, Christine J, Gabriel, Alem S, Moorman, Anthony, Amir Enshaei (779054), Fadhel M Lafta (779050), Claire Schwab (779055), Moorman, Anthony V, Rand, Vikki; id_orcid, Schwab, Claire, Ajay Vora (779060), Cockell, Simon, Alice Iliasova (779053)   +41 more
core   +1 more source

A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions. [PDF]

PLoS ONE, 2016
Comprehensive delineation of complex cellular networks requires high-throughput interrogation of genetic interactions. To address this challenge, we describe the development of a multiplex combinatorial strategy to assess pairwise genetic interactions ...
Victoria B Stockman, Lila Ghamsari, Gorka Lasso, Barry Honig, Sagi D Shapira, Harris H Wang   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Nature Communications
Cis-regulatory elements (CREs) are noncoding DNA regions regulating cell-type-specific gene expression programs by interacting with distal gene promoters.
S. Haydar, R. Bednarz, P. Laurette, I. Sobitov, N. Díaz i Pedrosa, P. Videm, T. Lueneburg, S. Kuß, H. Lahm, M. Dreßen, M. Krane, C. Schmidt, B. A. Grüning, N. Voigt, K. Streckfuss-Bömeke, R. Gilsbach   +15 more
doaj   +1 more source