Results 91 to 100 of about 4,748,947 (305)
Genetic Variation in the Promoter Region of Chitinase 3-Like 1 Is Associated with Atopy
American Journal of Respiratory and Critical Care Medicine, 2009 Abstract Rationale Atopy or atopic syndrome is an allergic hypersensitivity subject to hereditary influences. Aberrant expression of chitinase 3-like 1 (CHI3L1), also known as YKL-40 or HC gp-39, is involved in the pathogenesis of inflammatory and allergic diseases.
Myung Hyun, Sohn +9 more
openaire +3 more sources
A case of Dravet syndrome with a novel SCN1A gross deletion involving the promoter region
Human Genome VariationHere we present a case of Dravet syndrome in which a novel heterozygous deletion involving the promoter region of the SCN1A gene was identified using next-generation sequencing and multiple ligation-dependent probe amplification.
Eri Nakahara Sakamoto +7 more
doaj +1 more source
Nature Communications, 2018 Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with
Mun-Kit Choy +12 more
doaj +1 more source
Experimental and Molecular Medicine, 2020 Gene regulation: linking enhancers to specific promoters Super-enhancers are regions of DNA that highly activate the expression of specific genes. Research led by H.K.L. and L.H.
Xianke Zeng +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Feedback and molecular interactions in the process of light-induced carotenogenesis in Myxococcus xanthus [PDF]
Myxococcus xanthus is a soil-dwelling bacterium which produces carotenoids upon irradiation with blue light. Genetic analysis has allowed elucidation of transduction of the light signal to the carotenogenic machinery within the cell.
Whitworth, David E.
core
Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]
, 2012 The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Julia Metzner +13 more
core +1 more source
The role of genetic factors in breast cancer aetiology [PDF]
, 2010 Breast cancer is the most common cancer in women and is also the leading cause of cancermortality in women. There are several known risk factors for breast cancer including geneticfactors which account for at least 25% of the incidence of breast cancer ...
Hammond, Victoria Naomi
core +1 more source
Journal of Dairy Science: Inbreeding depression (InD) refers to the mean reduction in trait values due to inbreeding, with detrimental effects on survival, production, and reproduction traits that have been observed in many natural and domesticated populations.
Chang Xu +6 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source