Results 91 to 100 of about 593,021 (291)

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

Nature Communications, 2018
Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a widely used model to study cardiac genomics. Here, Choy et al. perform promoter capture Hi-C to map long-range chromosomal interactions of hESC-CMs and to study overlap of such regions with
Mun-Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven W. Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg-Gunn, Mikhail Spivakov, Peter Fraser, Bernard D. Keavney   +12 more
doaj   +1 more source

The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy

Experimental and Molecular Medicine, 2020
Gene regulation: linking enhancers to specific promoters Super-enhancers are regions of DNA that highly activate the expression of specific genes. Research led by H.K.L. and L.H.
Xianke Zeng, Hye Kyung Lee, Chaochen Wang, Precious Achikeh, Chengyu Liu, Lothar Hennighausen   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The genetics and genomics of Trypanosoma cruzi [PDF]

, 2007
Trypanosoma cruzi is a kinetoplastid parasite that causes Chagas disease. Trypanosomes are unusual organisms in many aspects of its genetics and molecular and cellular biology and considered a paradigm of the exception of the rule in the eukaryotic ...
Vazquez, Martin Pablo
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A genetic variation of the p38β promoter region is correlated with an increased risk of sporadic colorectal cancer

Oncology Letters, 2013
p38 plays a critical role in the proliferation, survival, migration and metastasis of colorectal cancer (CRC) cells. The present study assessed the correlation between a single nucleotide polymorphism (SNP) in the p38β promoter region (rs2235356, -1628A>G) and the predisposition of individuals to sporadic CRC in a case-control study.
HUANG, QINGHUA, CHEN, DIANKE, SONG, SHUNXIN, FU, XINHUI, WEI, YISHENG, LU, JIACHUN, WANG, LEI, WANG, JIANPING   +7 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Genomic partition of inbreeding depression in production traits of US Jersey cattle using functional annotations

Journal of Dairy Science
: Inbreeding depression (InD) refers to the mean reduction in trait values due to inbreeding, with detrimental effects on survival, production, and reproduction traits that have been observed in many natural and domesticated populations.
Chang Xu, Christian Maltecca, Francesco Tiezzi, John B. Cole, Sajjad Toghiani, Li Ma, Jicai Jiang   +6 more
doaj   +1 more source

Locus‐specific concordance of genomic alterations between tissue and plasma circulating tumor DNA in metastatic melanoma

Molecular Oncology, 2019
Circulating tumor DNA (ctDNA) may serve as a surrogate to tissue biopsy for noninvasive identification of mutations across multiple genetic loci and for disease monitoring in melanoma.
Leslie Calapre, Tindaro Giardina, Cleo Robinson, Anna L. Reid, Zeyad Al‐Ogaili, Michelle R. Pereira, Ashleigh C. McEvoy, Lydia Warburton, Nicholas K. Hayward, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Benhur Amanuel, Melanie Ziman, Elin S. Gray   +14 more
doaj   +1 more source

Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma

Infectious Agents and Cancer, 2017
Primary hepatocellular carcinoma (HCC) mainly develops in subjects chronically infected with hepatitis B (HBV) and C (HCV) viruses through a multistep process characterized by the accumulation of genetic alterations in the human genome.
Francesca Pezzuto, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello   +3 more
doaj   +1 more source