Results 111 to 120 of about 390,492 (308)

Role of phase-variable Mfa1 fimbriae of Phocaeicola vulgatus in its adhesion and proinflammatory activity toward gut epithelial cells

Gut Microbes Reports
Bacteroidaceae is a prominent family in the human gut microbiota. The bacteria within this family are characterized by phase variable regulation of diverse surface structures, such as capsular polysaccharides and outer membrane proteins.
Emmanuel Munyeshyaka, Haruyuki Nakayama-Imaohji, Hisashi Yamasaki, Ayano Tada, Nafisa Tabassum, Tomomi Kuwahara   +5 more
doaj   +1 more source

Association analysis identifies ZNF750 regulatory variants in psoriasis

BMC Medical Genetics, 2011
Background Mutations in the ZNF750 promoter and coding regions have been previously associated with Mendelian forms of psoriasis and psoriasiform dermatitis.
Birnbaum Ramon Y, Hayashi Genki, Cohen Idan, Poon Annie, Chen Haoyan, Lam Ernest T, Kwok Pui-Yan, Birk Ohad S, Liao Wilson   +8 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Rule-based clustering for gene promoter structure discovery [PDF]

, 2009
BACKGROUND: The genetic cellular response to internal and external changes is determined by the sequence and structure of gene-regulatory promoter regions.
Petrovic, Uros, Zupan, Blaz, Shaulsky, Gad, Curk, Tomaz   +3 more
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A global view of the oncogenic landscape in nasopharyngeal carcinoma : an integrated analysis at the genetic and expression levels [PDF]

, 2012
Previous studies have reported that the tumour cells of nasopharyngeal carcinoma (NPC) exhibit recurrent chromosome abnormalities. These genetic changes are broadly assumed to lead to changes in gene expression which are important for the pathogenesis of
Aicha Amari, Murray, Paul G, Dawson, Christopher W, Wei, Wenbin, Xiaoyi Chen (150873), Sim K. Sihota (150887), Shao, Jian-Yong, Andrew I Bell, Maloney, S.L., Nicholls, John M, Shao, J.Y., Aicha Amari (150894), Hu, C., K Dalia Derkaoui, Stephanie L Maloney, Wei, W., Arrand, J.R., Wenbin Wei (150871), Woodman, C.B., Sihota, Sim K, Murray, P.G., Ciaran B. Woodman (150878), Derkaoui, K.D., Ciaran B Woodman, Jian-Yong Shao (41845), Maloney, Stephanie L., Bell, Andrew I., Dawson, Christopher W., John M. Nicholls (150882), Derkaoui, K Dalia, Derkaoui, K. Dalia, Maloney, Stephanie L, Bell, A.I., Sihota, Sim K., Xiaoyi Chen, Lawrence S. Young (150912), Woodman, Ciaran B. J., Nicholls, J.M., Arrand, J. R. (John R.), Irène Joab (150885), Joab, Irène, Amari, Aicha, Arrand, John R, Woodman, Ciaran B, Wenbin Wei, Paul G. Murray (150907), Christopher W. Dawson (150910), Chen, X., Yao, Yunhong, Chunfang Hu, Dawson, C.W., Chunfang Hu (150868), K. Dalia Derkaoui (150892), Andrew I. Bell (150904), Chen, Xiaoyi, Young, Lawrence S., Joab, I., John R. Arrand (150915), Irène Joab, Christopher W Dawson, Nicholls, J. M. (John M.), Stephanie L. Maloney (150899), Yunhong Yao, Wei, Wenbin; id_orcid, Young, Lawrence S, Lawrence S Young, John R Arrand, John M Nicholls, Paul G Murray, Amari, A., Jian-Yong Shao, Bell, Andrew I; id_orcid, Yao, Y., Yunhong Yao (150880), Hu, Chunfang, Young, L.S., Sihota, S.K., Murray, Paul G., Sim K Sihota   +78 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Analysis of the promoter regions of disease-causing genes in maturity-onset diabetes of the young patients

, 2020
Maturity-onset diabetes of the young (MODY) is a form of monogenic diabetes caused by the variants in MODY-related genes. In addition to coding variants, variants in the promoter region of MODY-related genes can cause the disease as well.
Zdravković, Vera, Ristivojević, Bojan, Zukić, Branka, Ugrin, Milena, Karan-Đurašević, Teodora, Pavlović, Sonja, Komazec, Jovana   +6 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Genetic Variants in STAT3 Promoter Regions and Their Application in Molecular Breeding for Body Size Traits in Qinchuan Cattle

, 2018
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in leptin-mediated regulation of energy metabolism. This study investigated genetic variation in STAT3 promoter regions and verified their contribution to bovine body size ...
Yaning Wang, Gong Cheng, Rajwali Khan, Sen Wu, Linsen Zan, Yue Ning, Xiaoyu Wang, Le Zhang, Hongfang Guo, Hongbao Wang   +9 more
core   +1 more source