Results 111 to 120 of about 4,748,947 (305)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Haptoglobin and sickle cell polymorphisms and risk of active trachoma in Gambian children. [PDF]

, 2010
BACKGROUND: Susceptibility and resistance to trachoma, the leading infectious cause of blindness, have been associated with a range of host genetic factors.
Doherty, CP, Andrew M Prentice, Martin J. Holland, Hennig, Branwen J, Bailey Robin, Kirk A Rockett, Fulford Anthony J., Kwiatkowski, DP, Fulford, AJ, Sharon E. Cox, Kwiatkowski, Dominic, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Kirk A. Rockett, Sharon E Cox, Rockett, KA, Hennig Branwen J., Fulford, Anthony J, Dominic P. Kwiatkowski, Holland, MJ, Holland, Martin J, Cox, Sharon E, Mathilde Savy, Holland Martin J., Robin Bailey, Prentice, AM, Sirugo, G, Martin J Holland, Prentice, Andrew M, Anthony J Fulford, Sirugo, Giorgio, Bailey, Robin, Savy Mathilde, Conor P Doherty, Rockett, Kirk A, Bailey, R, Branwen J Hennig, Cox Sharon E., Doherty, Conor P, Cox, SE, Savy, M, Rockett Kirk A., Andrew M. Prentice, Prentice Andrew M., Anthony J. Fulford, Hennig, BJ, Conor P. Doherty, Sirugo Giorgio, Savy, Mathilde, Doherty Conor P., Branwen J. Hennig, Kwiatkowski, Dominic P, Giorgio Sirugo   +52 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Expression of the plasma prekallikrein gene: utilization of multiple transcription start sites and alternative promoter regions [PDF]

, 2005
The plasma prekallikrein gene is expressed in many different human tissues at distinctly different levels and therefore tissue-specific control of the gene transcription is likely.
Sidarovich, Viktoryia, Neth, Peter, Bhoola, Kanti D., Arnhold, Marianne, Fink, Edwin   +4 more
core   +1 more source

G-quadruplexes: Kinetic stability and effects on the c-KIT promoter

, 2013
In addition to the famous Watson & Crick model for B-form duplex DNA, guanine-rich DNA sequences can self-assemble under certain conditions to form a four-stranded structure known as a G-quadruplex. G-quadruplexes are composed of stacks of Gquartets,
Raouf, Tara
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Strähle, Uwe, Boshart, Michael, Schmid, Wolfgang, Miksicek, Richard, Jansen, Hans-Michael, Gloss, Bernd, Schlitz, Günther, Stewart, Francis   +7 more
core   +1 more source

Association analysis identifies ZNF750 regulatory variants in psoriasis

BMC Medical Genetics, 2011
Background Mutations in the ZNF750 promoter and coding regions have been previously associated with Mendelian forms of psoriasis and psoriasiform dermatitis.
Birnbaum Ramon Y, Hayashi Genki, Cohen Idan, Poon Annie, Chen Haoyan, Lam Ernest T, Kwok Pui-Yan, Birk Ohad S, Liao Wilson   +8 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Role of phase-variable Mfa1 fimbriae of Phocaeicola vulgatus in its adhesion and proinflammatory activity toward gut epithelial cells

Gut Microbes Reports
Bacteroidaceae is a prominent family in the human gut microbiota. The bacteria within this family are characterized by phase variable regulation of diverse surface structures, such as capsular polysaccharides and outer membrane proteins.
Emmanuel Munyeshyaka, Haruyuki Nakayama-Imaohji, Hisashi Yamasaki, Ayano Tada, Nafisa Tabassum, Tomomi Kuwahara   +5 more
doaj   +1 more source