Results 101 to 110 of about 4,748,947 (305)

HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children. [PDF]

, 2012
Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of HO-1 expression.
Madi Njie (177625), Walther, Brigitte, Cunnington, A., De Caul, A, Sebastian Weis, Ebonyi, A., Deininger Susanne, Aka Peter, Deininger, S., Peter Aka, Takem, Ebako N, Predazzi, Irene M, Conway David J., Predazzi, IM, Cunnington, Aubrey, Walther, Michael, Conway, DJ, Aubrey Cunnington, Njie, M., Predazzi, I. M., Weis Sebastian, Augustine Ebonyi (177659), Sarah Rowland-Jones, Walther Michael, Amambua-Ngwa, A., Sarah Rowland-Jones (74678), Scott M. Williams (177668), Robert Walton, Susanne Deininger (173844), Sirugo, G, Cunnington Aubrey, Njie, Madi, Williams Scott M., Sirugo, Giorgio, Weis, S, Augustine Ebonyi, Walton Robert, Aka, P, Aka, P., Rowland-Jones Sarah, Williams, Scott M, Williams, S. M., Ebonyi, A, Alfred Amambua-Ngwa (122336), Weis, Sebastian, De Caul, Adam, Williams, SM, Sebastian Weis (161447), Amambua-Ngwa Alfred, Takem Ebako N., Deininger, Susanne, Adam De Caul (177612), Giorgio Sirugo, Ebako N. Takem (177656), Amambua-Ngwa, A, Walton, Robert T., Ebonyi, Augustine, Alfred Amambua-Ngwa, Madi Njie, Michael Walther, Rowland-Jones, S., Giorgio Sirugo (62489), Aka, Peter, Walton, R, Njie, M, De Caul Adam, Njie Madi, Rowland-Jones, Sarah, Takem, EN, Predazzi Irene M., Takem, E. N., Robert Walton (177664), Amambua-Ngwa, Alfred, Conway, D. J., Adam De Caul, Walther, B., Weis, S., Deininger, S, Susanne Deininger, Aubrey Cunnington (177640), Conway, David J, Peter Aka (177618), Sirugo, G., Ebako N Takem, David J Conway, David J. Conway (34880), de Caul, A., Irene M. Predazzi (177634), Brigitte Walther (130764), Walther, M, Walther, M., Walther Brigitte, Walton, Robert, Cunnington, A, Scott M Williams, Irene M Predazzi, Sirugo Giorgio, Walther, B, Rowland-Jones, S, Brigitte Walther, Michael Walther (130767), Ebonyi Augustine   +101 more
core   +1 more source

Locus‐specific concordance of genomic alterations between tissue and plasma circulating tumor DNA in metastatic melanoma

Molecular Oncology, 2019
Circulating tumor DNA (ctDNA) may serve as a surrogate to tissue biopsy for noninvasive identification of mutations across multiple genetic loci and for disease monitoring in melanoma.
Leslie Calapre, Tindaro Giardina, Cleo Robinson, Anna L. Reid, Zeyad Al‐Ogaili, Michelle R. Pereira, Ashleigh C. McEvoy, Lydia Warburton, Nicholas K. Hayward, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Benhur Amanuel, Melanie Ziman, Elin S. Gray   +14 more
doaj   +1 more source

Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma

Infectious Agents and Cancer, 2017
Primary hepatocellular carcinoma (HCC) mainly develops in subjects chronically infected with hepatitis B (HBV) and C (HCV) viruses through a multistep process characterized by the accumulation of genetic alterations in the human genome.
Francesca Pezzuto, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A genetic variation of the p38β promoter region is correlated with an increased risk of sporadic colorectal cancer

Oncology Letters, 2013
p38 plays a critical role in the proliferation, survival, migration and metastasis of colorectal cancer (CRC) cells. The present study assessed the correlation between a single nucleotide polymorphism (SNP) in the p38β promoter region (rs2235356, -1628A>G) and the predisposition of individuals to sporadic CRC in a case-control study.
HUANG, QINGHUA, CHEN, DIANKE, SONG, SHUNXIN, FU, XINHUI, WEI, YISHENG, LU, JIACHUN, WANG, LEI, WANG, JIANPING   +7 more
openaire   +3 more sources

DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.

PLoS ONE, 2017
The bromodomain containing 1 gene, BRD1 is essential for embryogenesis and CNS development. It encodes a protein that participates in histone modifying complexes and thereby regulates the expression of a large number of genes.
Mads Dyrvig, Per Qvist, Jacek Lichota, Knud Larsen, Mette Nyegaard, Anders D Børglum, Jane H Christensen   +6 more
doaj   +1 more source

Multiple Changes Underlie Allelic Divergence of CUP2 Between Saccharomyces Species

G3: Genes, Genomes, Genetics, 2019
Under the model of micromutationism, phenotypic divergence between species is caused by accumulation of many small-effect changes. While mapping the causal changes to single nucleotide resolution could be difficult for diverged species, genetic ...
Xueying C. Li, Justin C. Fay
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Examination of the brassica napus β-Keto-Acyl carrier protein reductase promoter for regulatory Cis-acting elements [PDF]

, 2002
Major interest has focused on the identification of regulatory factors involved in lipid biosynthesis. This study examined the B.napus β-Keto-ACP reductase 5' sequence for potential regulatory cis-acting elements.
Young, Clare Elisabeth
core  

Identification of promoter regions in the Arabidopsis thaliana atExt1 extensin gene controlling late responses to wounding and pathogen attack

, 2013
The Arabidopsis thaliana (L.) Heynh. atExt1 extensin gene is expressed in a cell and tissue-specific manner, in response to developmental cues, and is inducible by a wide range of biotic and abiotic stresses.
G. Merkouropoulos, K. Roberts, A. H. Shirsat   +2 more
core   +1 more source