Results 101 to 110 of about 390,492 (308)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Advances in plant gene-targeted and functional markers: a review [PDF]

, 2013
Public genomic databases have provided new directions for molecular marker development and initiated a shift in the types of PCR-based techniques commonly used in plant science.
Ildikó Varga, Poczai, Péter, Neil Bell, Hyvönen Jaakko, Valkonen, Jari PT, Maarja Laos, Hyvönen, Jaakko, Cseh, András, Varga Ildikó, Varga, Ildikó, Laos, Maarja, Cseh András, Bell Neil, Poczai Péter, Valkonen, Jari, Cseh, András Attila, Péter Poczai, Jari PT Valkonen, Valkonen Jari PT, Jaakko Hyvönen, Bell, Neil, András Cseh, Laos Maarja   +22 more
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Multiple Changes Underlie Allelic Divergence of CUP2 Between Saccharomyces Species

G3: Genes, Genomes, Genetics, 2019
Under the model of micromutationism, phenotypic divergence between species is caused by accumulation of many small-effect changes. While mapping the causal changes to single nucleotide resolution could be difficult for diverged species, genetic ...
Xueying C. Li, Justin C. Fay
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Function of the upstream activating factor in chromatin structure organization and transcriptional regulation at the yeast ribosomal DNA

, 2010
Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a ...
Götze, Hannah
core   +1 more source

DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele.

PLoS ONE, 2017
The bromodomain containing 1 gene, BRD1 is essential for embryogenesis and CNS development. It encodes a protein that participates in histone modifying complexes and thereby regulates the expression of a large number of genes.
Mads Dyrvig, Per Qvist, Jacek Lichota, Knud Larsen, Mette Nyegaard, Anders D Børglum, Jane H Christensen   +6 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Investigation of XvSap promoters from the resurrection plant, Xerophyta viscosa

, 2012
Includes bibliographical references.The XvPSap1 promoter derived from Xerophyta viscosa has been demonstrated to be stress-inducible during dehydration in transgenic Nicotiana tabacum, black Mexican sweetcorn cells and Zea mays. To improve this promoter,
Ellick, Tamaryn Lorean
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB As Novel Risk Loci for Systemic Sclerosis [PDF]

, 2011
Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating and life-threatening inflammatory rheumatic disease, with a largely unknown pathogenesis ...
P. Amouyel, MELCHERS I, Cusi, D., Amouye, Philippe, Jerome Avouac, Melchers, Inga, Salvi Erika, Müller, Martina, ALLANORE Y, Damjanov Nemanja, Meyer Oliver, HACHULLA E, Nemanja Damjanov, Hunzelmann Nicolas, I. Melchers, H.-Erich Wichmann, Wichmann, H.-E., Ulf Müller-Ladner, Lambert, J.C., Ruiz, B., AMOUYEL P, Munnich, A., Riemekasten, Gabriella, Cracowski Jean-Luc, Distler, J.H., AVOUAC J, CONTI C, Hachulla Eric, Dupuy, Anne-Marie, Dieude, Philippe, AIRO P, Munnich Arnold, Caramaschi, Paola, Avouac, Jerome, Nicolas Hunzelmann, Inga Melchers, Lambert J. C, Allanore, Y., C. Boileau, Conti, Costanza, Diot, Elisabeth, Lambert Jean-Charles, A. M. Dupuy, O. Meyer, Yannick Allanore, Avouac, J., Martinez, Maria, Ruiz Barbara, Otylia Kowal Bielecka, Wichmann, H-Erich, Luc Letenneur, J. Avouac, P. Caramaschi, Mouthon Luc, Wipff, J., Wichmann, H.-Erich, Dieudé Philippe, C. Conti, Meyer, O., E. Hachulla, M. Müller, Mouthon, L., Arnold Munnich, Avouac Jérôme, Damjanov, Nemanja, Gabriele Valentini, Valentini, G., Müller-Ladner Ulf, Caramaschi Paola, Müller, M., Tiev, Kiet, Martinez, M., Meyer, Oliver, MARTINEZ M., Kowal-Bielecka, O., H. Erich Wichmann, Distler, Jorg, H. W., A. Munnich, Matucci-Cerinic Marco, Dupuy Anne Marie, László Czirjak, G. Valentini, DAMJANOV N, MEYER O, Kahan, Andre, Melchers Inga, RICCIERI V, Saad, M., Jorg H W Distler, Cusi Daniele, Ruiz, Barbara, Kahan André, Martina Muller, E. Salvi, WIPFF J, E. Diot, Distler J, Müller Martina, CARAMASCHI P, DIOT E, Erika Salvi, J. C. Lambert, HUNZELMANN N, Matucci-Cerinic, M., Boileau, Catherine, Dieudé, P., Airo, P., Cusi, Daniele, Riccieri, Valeria, Müller-Ladner, U., J. Wipff, L. Czirják, Distler, Jorg H. W., Hachulla, E., Czirjak, Laszlo, Czijak L, Y. Allanore, MUNNICH A, Mohamad Saad, Czirják, L., Wipff, Julien, K. Tiev, L. Letenneur, Letenneur, Luc, Maria Martinez, Conti Costanza, Airo Paolo, Kowal-Bielecka, Otylia, N. Damjanov, MÜLLER LADNER U, SALVI E, WICHMANN HE, Valentini Gabriele, Jorg H. W. Distler, Paolo Airo, DUPUY AM, Valentini G, CUSI D, MÜLLER M, Mouthon, Luc, J. L. Cracowski, Damjanov, N., LAMBERT JC, Distler Jorg H. W., H-Erich Wichmann, P. Dieudé, Diot, E., MATUCCI CERINIC, Marco, Paola Caramaschi, Valentini, Gabriele, Hachulla, Eric, Jean Luc Cracowski, Tiev Kiet, CRACOWSKI JL, Airo, Paolo, Costanza Conti, Jean-Charles Lambert, RUIZ B, Daniele Cusi, Martinez Maria, Valeria Riccieri, M. Matucci Cerinic, MATUCCI CERINIC M, Eric Hachulla, H. E. Wichmann, Lambert, Jean-Charles, Wichmann, Heinz-Erich, Tiev, K., Kiet Tiev, Catherine Boileau, MOUTHON L, Riemekasten, G., Jean Charles Lambert, L. Mouthon, Caramaschi, P., Marco Matucci-Cerinic, SAAD M, B. Ruiz, Riemekasten Gabriella, J. H. Distler, BOILEAU C, Boileau Catherine, Philippe Amouyel, Riccieri Valeria, Munnich, Arnold, Cracowski, Jean-Luc, Gabriella Riemekasten, DIEUDÉ P, N. Hunzelmann, Saad Mohamad, Letenneur Luc, Czirják László, Allanore, Yannick, Philippe Dieude, Julien Wipff, Müller-Ladner, Ulf, KOWAL BIELECKA O, LETENNEUR L, Kowal-Bielecka Otylia, Elisabeth Diot, G. Riemekasten, KAHAN A, Wichmann H.-Erich, Salvi, E., Matucci-Cerinic, Marco, Dupuy, A.M., D.M. Cusi, Oliver Meyer, U. Müller Ladner, Hunzelmann, Nicolas, Allanore Yannick, Wipff Julien, Cracowski, J.L., Saad, Mohamad, Barbara Ruiz, RIEMEKASTEN G, O. Kowal Bielecka, Conti, C., M. Martinez, Jean-Luc Cracowski, P. Airo, CZIRJÁK L, Amouyel, Philippe, Letenneur, L., Salvi, Erika, DISTLER JH, Amouyel, P., Distler, Jorg,, Luc Mouthon, V. Riccieri, Hunzelmann, N., Ulf Muller Ladner, TIEV K, Dupuy, Anne Marie, Diot Elisabeth, Kahan, A., Riccieri, V., Marco Matucci Cerinic, André Kahan, Boileau, C., M. Saad, A. Kahan, Anne Marie Dupuy, Amouyel Philippe, Otylia Kowal-Bielecka, Melchers, I.   +245 more
core   +1 more source