Results 51 to 60 of about 897,116 (253)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Trans Nzoia County Investment Plan 2025/2026 [PDF]

This Investment Plan for the financial year 2025 marks a significant milestone in the journey of Trans Nzoia County to realise its vision of becoming an “agro-industrialised county with high quality of life for residents”.
County Government of Trans Nzoia
core   +1 more source

pvz22/Trans-reg_pleiotropy: Trans-reg_pleiotropy

, 2022
Scripts used in "Pleiotropic effects of trans-regulatory mutations on fitness and gene expression." (Vande Zande, Hill, and Wittkopp ...
pvz22
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Trans-itioning lives, trans-forming places

, 2023
Trans-itioning lives, trans-forming ...
Merinda Kelly (14287493), Louise Paatsch (13088415), Julianne Moss (9704930), Eve Mayes (13083660), Shaun Rawolle (13095825)   +4 more
core  

The small FNR regulon of Neisseria gonorrhoeae: comparison with the larger Escherichia coli FNR regulon and interaction with the NarQ-NarP regulon [PDF]

, 2007
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Cole, JA, Overton, TW, McGowan, SJ, Saunders, Nigel, Lori AS Snyder, Saunders, NJ, Saunders, Nigel J., Jeff A Cole, Tim W Overton, Snyder, Lori A. S., Harry Smith, Snyder, LA, McGowan, S, Overton, Tim W., Smith, H, Nigel J Saunders, Simon J McGowan, McGowan, Simon J., Overton, Timothy; id_orcid, Snyder, Lori, Whitehead, Rebekah, Whitehead, RN, Snyder, LAS, Snyder, Lori A.S., Smith, Harry, Rebekah N Whitehead, Whitehead, Rebekah N., Cole, Jeffrey, Cole, Jeff A.   +28 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Alternative splicing of activator CcbHLH1 gene accounts for anthocyanin absence in white cornflower

Ornamental Plant Research
Anthocyanins play crucial roles in conferring multicolored characteristics to higher plant organs. Previous studies have investigated the absence of anthocyanin accumulation in white cornflower petals, where the anthocyanin biosynthesis pathway was ...
Chengyan Deng, Xiaofan Zheng, Jiaying Wang, Yanfei Li, Jingjing Li, Min Lu, Ruina Gao, Chenyuan Ji, Qinghe Hao, Silan Dai   +9 more
doaj   +1 more source

CTD small phosphatase like 2 (CTDSPL2) can increase ε- and γ-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood

BMC Cell Biology, 2010
Background A potential strategy for treatment of sickle cell disease (SCD) and β-thalassemia in adults is reactivation of the ε- and γ-globin genes in the adult.
Zhang Jun-Wu, Yu Hai-Chuan, Zhang Xin, Ma Yan-Ni   +3 more
doaj   +1 more source

trans-Activation of a globin promoter in nonerythroid cells. [PDF]

Molecular and Cellular Biology, 1991
We show that expression in fibroblasts of a single cDNA, encoding the erythroid DNA-binding protein Eryf1 (GF-1, NF-E1), very efficiently activates transcription of a chicken alpha-globin promoter, trans-Activation in these cells occurred when Eryf1 bound to a single site within a minimal globin promoter.
T, Evans, G, Felsenfeld
openaire   +2 more sources