Results 61 to 70 of about 807,190 (203)

CTD small phosphatase like 2 (CTDSPL2) can increase ε- and γ-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood

BMC Cell Biology, 2010
Background A potential strategy for treatment of sickle cell disease (SCD) and β-thalassemia in adults is reactivation of the ε- and γ-globin genes in the adult.
Zhang Jun-Wu, Yu Hai-Chuan, Zhang Xin, Ma Yan-Ni   +3 more
doaj   +1 more source

DNA-PK-mediated CRTC2 phosphorylation promotes NHEJ and suppresses antitumor immunity via relocation to repair complexes

Nature Communications
Genotoxic stress or exogenous DNA damage induces transcription arrest, enabling efficient DNA repair. Transcription activators directly participate in DNA damage repair (DDR), but the trans-regulatory mechanisms linking transcription and DDR remain ...
Fangdi Zou, Zhiqi Yao, Xiaohan Dong, Yang Liu, Zhanjie Xiu, Meixi Wang, Xiaofeng Liu, Xinlu Wang, Lin Sun, Jian Wang, Shuai Ma, Heng Zhang, Kaishun Hu, Yan Sun, Kexin Chen, Zhiyong Yuan, Lei Shi, Zhiqiang Wu, Zeyun Mi   +18 more
doaj   +1 more source

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

Retrovirology, 2009
The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in infected patients under HAART since interruption of the treatment inevitably leads to a rebound of plasma viremia.
Van Lint Carine, Colin Laurence
doaj   +1 more source

Transcriptional activators in yeast [PDF]

, 2006
Eukaryotic transcription activation domains (ADs) are not well defined on the proteome scale. We sys-tematicallly tested 6000 yeast proteins for trans-criptional activity using a yeast one-hybrid system and identified 451 transcriptional activators.
Takashi Ito, Sindhu Thomas, Tomoko Chiba, Ra V. Rajagopala, Peter Uetz   +4 more
core  

Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy

Molecular Cancer, 2019
Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles.
Hong-Tao Chen, Hao Liu, Min-Jie Mao, Yuan Tan, Xiang-Qiong Mo, Xiao-Jun Meng, Meng-Ting Cao, Chu-Yu Zhong, Yan Liu, Hong Shan, Guan-Min Jiang   +10 more
doaj   +1 more source

A Role for Soluble IL-6 Receptor in Osteoarthritis

Journal of Functional Morphology and Kinesiology, 2017
Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) and osteoarthritis (OA).
Graham Akeson, Charles J. Malemud
doaj   +1 more source

Enhancing Citrus Resistance against Huanglongbing using Plant Activators and Copper Acetate [PDF]

Citrus greening (Huanglongbing or HLB) is one of the most destructive citrus diseases. It is caused by the phloem-limited bacterium Candidatus Liberibacter spp. and is difficult to control.
Nasir Ahmed Rajput, Adeel Sultan, Muhammad Atiq   +2 more
core   +1 more source

Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specific

Cell Stress & Chaperones
Cells counteract proteotoxic conditions by launching transcriptional stress responses. While synthesis of heat shock proteins (HSPs) upon acute stress is well characterized, how distinct proteotoxic conditions reshape the transcriptome remains poorly ...
Adelina Rabenius, Intisar Salim, Hilmar Lindström, Anastasiya Pak, Serhat Aktay, Anniina Vihervaara   +5 more
doaj   +1 more source

Trans Nzoia County Investment Plan 2025/2026 [PDF]

This Investment Plan for the financial year 2025 marks a significant milestone in the journey of Trans Nzoia County to realise its vision of becoming an “agro-industrialised county with high quality of life for residents”.
County Government of Trans Nzoia
core   +1 more source

The human disease-associated gene ZNFX1 controls inflammation through inhibition of the NLRP3 inflammasome

The EMBO Journal
Inherited deficiency of zinc finger NFX1-type containing 1 (ZNFX1), a dsRNA virus sensor, is associated with severe familial immunodeficiency, multisystem inflammatory disease, increased susceptibility to viruses, and early mortality.
Jing Huang, Yao Wang, Xin Jia, Changfeng Zhao, Meiqi Zhang, Mi Bao, Pan Fu, Cuiqin Cheng, Ruona Shi, Xiaofei Zhang, Jun Cui, Gang Wan, Anlong Xu   +12 more
doaj   +1 more source