Results 61 to 70 of about 807,180 (300)

Trans(Gender) Justice Teach-In: The (Literal) Debate for Trans Lives - Insight from Trans Elected Officials (2023-12-13)

, 2023
6:00 p.m. ET / Virtual / Free; Koslowski, FinkeUniversity of Minnesota Duluth. Office of Diversity and Inclusion. (2023). Trans(Gender) Justice Teach-In: The (Literal) Debate for Trans Lives - Insight from Trans Elected Officials (2023-12-13).
University of Minnesota Duluth. Office of Diversity and Inclusion
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

CTD small phosphatase like 2 (CTDSPL2) can increase ε- and γ-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood

BMC Cell Biology, 2010
Background A potential strategy for treatment of sickle cell disease (SCD) and β-thalassemia in adults is reactivation of the ε- and γ-globin genes in the adult.
Zhang Jun-Wu, Yu Hai-Chuan, Zhang Xin, Ma Yan-Ni   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Introduction: Affective Histories of Queer and Trans Activism

SQS – Suomen Queer-tutkimuksen Seuran lehti, 2023
Non peer ...
Alasuutari, Varpu, Bootsmann, Merlin Sophie, Dynda, Barbara, Meier-Brix, Orlando, Zender, Ivo   +4 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

Retrovirology, 2009
The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in infected patients under HAART since interruption of the treatment inevitably leads to a rebound of plasma viremia.
Van Lint Carine, Colin Laurence
doaj   +1 more source

pvz22/Trans-reg_pleiotropy: Trans-reg_pleiotropy

, 2022
Scripts used in "Pleiotropic effects of trans-regulatory mutations on fitness and gene expression." (Vande Zande, Hill, and Wittkopp ...
pvz22
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

GluK2-trans

, 2015
The subdirectory /MD includes five free MD simulation trajectories of GluK2-trans complex described in the manuscript. The subdirectory /isomerization includes five forced switching simulation trajectories from trans-gluazo to cis-gluazo.
Marcus Elstner (394014), Wolter, Tino, Trauner, Dirk, Tino Wolter (394013), Guo, Yanan, Martin Sumser (787844), Dirk Trauner (549007), Tomáš Kubař (787843), Elstner, Marcus, Yanan Guo (116950), Kubař, Tomáš, Sumser, Martin   +11 more
core   +1 more source