Results 61 to 70 of about 897,116 (253)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Spx inhibits expression of the SwrA•DegU master flagellar activator in Bacillus subtilis
Journal of BacteriologyFlagella are trans-envelope nanomachines expressed from genes organized in a complex regulatory hierarchy governed at the highest level by transcription factors called master activators. The master activator of flagellar biosynthesis in Bacillus subtilis
Abigail E. Jackson +3 more
doaj +1 more source
BAG1L Enhances Trans-activation Function of the Vitamin D Receptor [PDF]
Journal of Biological Chemistry, 2000 The vitamin D receptor (VDR) is a member of the steroid/retinoid receptor superfamily of nuclear receptors that has potential tumor-suppressive functions. We show here that VDR interacts with and is regulated by BAG1L, a nuclear protein that binds heat shock 70-kDa (Hsp70) family molecular chaperones.
Guzey, M, Takayama, S, Reed, JC
openaire +4 more sources
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Trans Nzoia County Programme Based Budget 2025/2026 [PDF]
The FY 2025/2026, Trans Nzoia County presents its decisive step forward through the Annual Development Plan (ADP) and budget framework aligned with its medium-term strategic ambitions.
County Government of Trans Nzoia
core +1 more source
, 2023 6:00 p.m. ET / Virtual / Free; Koslowski, FinkeUniversity of Minnesota Duluth. Office of Diversity and Inclusion. (2023). Trans(Gender) Justice Teach-In: The (Literal) Debate for Trans Lives - Insight from Trans Elected Officials (2023-12-13).
University of Minnesota Duluth. Office of Diversity and Inclusion
core
Trans Ecologies Symposium [PDF]
, 2023 ‘The Shelled Gastropod: Trans-Corporeality In Necro-Ecologies’ was presented as part of the Trans Ecologies Symposium, Department of Geography at Durham University. Abstract: This paper contributes to contemporary dialogues on the permeability of bodies,
Sharples, V.
core
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
, 2016 Retroperitoneal soft tissue sarcomas (RPS) are rare tumors. Surgery is the mainstay of curative therapy, but local recurrence is common. No recommendations concerning the best management of recurring disease have been developed so far.
Jakob, Jens +1 more
core +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source