Results 71 to 80 of about 897,116 (253)
Nature CommunicationsGenotoxic stress or exogenous DNA damage induces transcription arrest, enabling efficient DNA repair. Transcription activators directly participate in DNA damage repair (DDR), but the trans-regulatory mechanisms linking transcription and DDR remain ...
Fangdi Zou +18 more
doaj +1 more source
Retrovirology, 2009 The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in infected patients under HAART since interruption of the treatment inevitably leads to a rebound of plasma viremia.
Van Lint Carine, Colin Laurence
doaj +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Packing timber during construction of line [picture] /
, 1917 "The rose series W.13"; Commonwealth Railways logo with map of Australia --back of photo.; P1877. Postcard photograph of the construction of the Trans-Australian Railway showing camel teams carting packing ...
Trans-Australian Railway.
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IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Molecular Cancer, 2019 Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles.
Hong-Tao Chen +10 more
doaj +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
A Role for Soluble IL-6 Receptor in Osteoarthritis
Journal of Functional Morphology and Kinesiology, 2017 Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) and osteoarthritis (OA).
Graham Akeson, Charles J. Malemud
doaj +1 more source
[Passengers on Board Trans-Texas Airways Plane]
, 1955 Photograph of a Trans-Texas Airways pilot and a family of passengers standing alongside the plane, as if about to board. The pilot holds a ticket which the father and one son look at. The mother and a younger son look on. "Trans-Texas Airways" and a logo
Douglass, Neal
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, 2015 The subdirectory /MD includes five free MD simulation trajectories of GluK2-trans complex described in the manuscript. The subdirectory /isomerization includes five forced switching simulation trajectories from trans-gluazo to cis-gluazo.
Marcus Elstner (394014) +11 more
core +1 more source