Results 71 to 80 of about 807,180 (300)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Cancer, 2019 Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles.
Hong-Tao Chen +10 more
doaj +1 more source
Packing timber during construction of line [picture] /
, 1917 "The rose series W.13"; Commonwealth Railways logo with map of Australia --back of photo.; P1877. Postcard photograph of the construction of the Trans-Australian Railway showing camel teams carting packing ...
Trans-Australian Railway.
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A Role for Soluble IL-6 Receptor in Osteoarthritis
Journal of Functional Morphology and Kinesiology, 2017 Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) and osteoarthritis (OA).
Graham Akeson, Charles J. Malemud
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
[Passengers on Board Trans-Texas Airways Plane]
, 1955 Photograph of a Trans-Texas Airways pilot and a family of passengers standing alongside the plane, as if about to board. The pilot holds a ticket which the father and one son look at. The mother and a younger son look on. "Trans-Texas Airways" and a logo
Douglass, Neal
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Enhancing Citrus Resistance against Huanglongbing using Plant Activators and Copper Acetate [PDF]
Citrus greening (Huanglongbing or HLB) is one of the most destructive citrus diseases. It is caused by the phloem-limited bacterium Candidatus Liberibacter spp. and is difficult to control.
Nasir Ahmed Rajput +2 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The EMBO JournalInherited deficiency of zinc finger NFX1-type containing 1 (ZNFX1), a dsRNA virus sensor, is associated with severe familial immunodeficiency, multisystem inflammatory disease, increased susceptibility to viruses, and early mortality.
Jing Huang +12 more
doaj +1 more source