Results 41 to 50 of about 18,250,723 (243)

Expression of GATA‐3 During Lymphocyte Differentiation and Mouse Embryogenesis [PDF]

Journal of Immunology Research, 1992
The GATA family of C4 zinc‐finger transcription factors has been implicated in tissuespecific gene regulation in birds and mammals. One of the members of this family, GATA‐3, is reportedly expressed specifically in the T‐cell lineage, where it interacts with GATA motifs in the TCR‐αα, TCR‐β/, and TCR‐δ enhancers, thereby controlling the T‐cell ...
Oosterwegel, M.A., Timmerman, J., Leiden, J., Clevers, J.C.   +3 more
openaire   +3 more sources

Immunohistoochemical evaluation of GATA-3, pAKT and Ki-67 in triple negative breast carcinoma

Journal of Pathology of Nepal, 2017
Background: Triple-negative breast cancers lack expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor -2. These tumors have been known to be clinically aggressive. We evaluate GATA-3, pAKT and Ki-67 expression
Gopi Aryal, Sameer Chhetri Aryal, Yurie Soejima, Victoria Sheckler, Yoshinobu Eishi, Motoji Sawabe   +5 more
doaj   +1 more source

Suppression of GATA-3 nuclear import and phosphorylation: a novel mechanism of corticosteroid action in allergic disease.

PLoS Medicine, 2009
BackgroundGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing
Kittipong Maneechotesuwan, Xin Yao, Kazuhiro Ito, Elen Jazrawi, Omar S Usmani, Ian M Adcock, Peter J Barnes   +6 more
doaj   +1 more source

Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3. [PDF]

PLoS ONE, 2015
Mast cell (MC) degranulation is the foundation of the acute phase of allergic rhinitis (AR). Previously, downregulation of GATA binding protein 3 (GATA-3) was shown to suppress MC activation in an AR mouse model.
Yu-Qin Deng, Ya-Qi Yang, Shui-Bin Wang, Fen Li, Meng-Zhi Liu, Qing-Quan Hua, Ze-Zhang Tao   +6 more
doaj   +1 more source

Constitutive phosphorylation of GATA-1 at serine²⁶ attenuates the colony-forming activity of erythrocyte-committed progenitors.

PLoS ONE, 2013
We previously reported that IL-3 signaling induces phosphorylation of GATA-1 at the serine²⁶ position, which contributes to IL-3-mediated anti-apoptotic response. Here, we demonstrate that phosphorylation of GATA-1 at serine²⁶ is also transiently induced
Kou-Ray Lin, Chung-Leung Li, Jeffrey Jong-Young Yen, Hsin-Fang Yang-Yen   +3 more
doaj   +1 more source

FoxP3, GATA‐3 and T‐bet expression in elderly asthma [PDF]

Clinical & Experimental Allergy, 2010
Cite this as: S. Vale‐Pereira, A. Todo‐Bom, L. Geraldes, C. Schmidt‐Weber, C. A. Akdis and A. Mota‐Pinto, Clinical & Experimental Allergy, 2011 (41) 490–496.SummaryBackground Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role.
Vale-Pereira, S, Todo-Bom, A, Geraldes, L, Schmidt-Weber, Carsten, Akdis, C A, Mota-Pinto, A   +5 more
openaire   +5 more sources

GATA-3 localization shapes lymphocyte function

Cell Reports
Despite the crucial roles of GATA-3 in lymphocyte biology, little is known about its intracellular distribution and the mechanisms regulating its nuclear import. Single-cell analyses on confocal microscopy images revealed that GATA-3 was enriched in the nucleus of naive and T helper (Th)2 cells, whereas Th1 cells preferentially accumulated it in the ...
Saikali, Philippe, Dzamukova, Maria, Stehle, Christina, Nguyen, Trung Viet, Brunner, Tobias M., Baumann, Claudia, Hegazy, Ahmed N., Kaufmann, Stefan H. E., Romagnani, Chiara, Löhning, Max   +9 more
openaire   +5 more sources

GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1.

, 2004
Cytochrome P450c17 catalyzes steroidogenic 17alpha-hydroxylase and 17,20 lyase activities. Expression of the gene for P450c17 is cAMP dependent, tissue specific, developmentally programmed, and varies among species.
Miller, Walter L., Flück, Christa
core   +1 more source

Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus [PDF]

, 1996
The myosin light-chain 1/3 locus (MLC1/3) is regulated by two promoters and a downstream enhancer element which produce two protein isoforms in fast skeletal muscle at distinct stages of mouse embryogenesis. We have analyzed the expression of transcripts
McGrew, M J; id_orcid, Hasegawa, K, Bogdanova, N, Kitsis, R N, Rosenthal, N, Hughes, S H   +5 more
core  

Knock-in Mutation of Transcription Factor GATA-3 into the GATA-1 Locus: Partial Rescue of GATA-1 Loss of Function in Erythroid Cells [PDF]

, 1998
Transcription factors of the GATA-family are essential for proper development of diverse tissues or cell types. GATA-1 is required for differentiation of two hematopoietic lineages (red blood cells and megakaryocytes), whereas GATA-3 is essential for T ...
Browne, Carol P., Tsai, Fong-Ying, Orkin, Stuart H.   +2 more
core   +1 more source