Results 41 to 50 of about 18,362,222 (202)

Knock-in Mutation of Transcription Factor GATA-3 into the GATA-1 Locus: Partial Rescue of GATA-1 Loss of Function in Erythroid Cells [PDF]

, 1998
Transcription factors of the GATA-family are essential for proper development of diverse tissues or cell types. GATA-1 is required for differentiation of two hematopoietic lineages (red blood cells and megakaryocytes), whereas GATA-3 is essential for T ...
Browne, Carol P., Tsai, Fong-Ying, Orkin, Stuart H.   +2 more
core   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

GATA-3 and Its Association with Allergic Diseases and Immune Regulation: A Systematic Review

International Journal of Translational Medicine
Background/Objectives: GATA-binding protein 3 (GATA-3) is a crucial transcription factor that drives type 2 immune responses, and it is actively involved in allergic conditions such as asthma, allergic rhinitis (AR), and atopic dermatitis (AD).
Jamal Nasser Saleh Al-Maamari, Junaidi Khotib, Mahardian Rahmadi, Yusuf Alif Pratama, Nadia Ahmed Nasser Hosrom   +4 more
doaj   +1 more source

Expression and Genetic Interaction of Transcription Factors GATA-2 and GATA-3 during Development of the Mouse Central Nervous System [PDF]

, 1999
Here we examine the expression of transcription factors GATA-2 and GATA-3 during early stages of embryonic development in the central nervous system (CNS) of the mouse.
Fujiwara, Yuko, Tsai, Fong-Ying, Orkin, Stuart H., Nardelli, Jeannette, Thiesson, Danielle   +4 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Physical and Functional Interaction between GATA-3 and Smad3 Allows TGF-β Regulation of GATA Target Genes [PDF]

, 2002
Background: Members of the GATA family of zinc finger transcription factors are genetically controlled “master” regulators of development in the hematopoietic and nervous systems.
Blokzijl, Andries, Carlos F. Ibáñez, Ibáñez, Carlos F., Peter ten Dijke, ten Dijke, Peter, Andries Blokzijl   +5 more
core   +2 more sources

MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li, Yang Liu, Hua Chen, Jialin Li, Xinchun Li, Yanmin Chen   +5 more
wiley   +1 more source

Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region. [PDF]

PLoS ONE, 2016
The T helper type 2 (Th2) locus control region (LCR) regulates Th2 cell differentiation. Several transcription factors bind to the LCR to modulate the expression of Th2 cytokine genes, but the molecular mechanisms behind Th2 cytokine gene regulation are ...
Kiwan Kim, Najung Kim, Gap Ryol Lee
doaj   +1 more source

GATA-3 transcriptional imprinting in Th2 lymphocytes: A mathematical model

, 2002
Immunological memory involves the fast recall of cytokine expression by T helper (Th) lymphocytes. Two distinct profiles of cytokine expression, Th1 and Th2, can be induced by antigen and polarizing signals during activation of naive Th cells and can ...
Max Löhning, Thomas Höfer, Holger Nathansen, Reinhart Heinrich, Andreas Radbruch   +4 more
core   +1 more source

Partial Rescue of GATA-3 by Yeast Artificial Chromosome Transgenes [PDF]

, 1998
GATA-3 is essential for murine embryonic development, but elucidating the genetic controls over the complex temporal and tissue-specific transcriptional regulatory pattern of this transcription factor gene has been problematic.
Lakshmanan, Ganesh, Lieuw, KH, Lakshmanan, G, Engel, JD, Grosveld, Frank, Engel, James Douglas, Lieuw, Ken H   +6 more
core   +1 more source