Results 31 to 40 of about 18,362,222 (202)
PLoS Medicine, 2009 BackgroundGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing
Kittipong Maneechotesuwan +6 more
doaj +1 more source
Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3. [PDF]
PLoS ONE, 2015 Mast cell (MC) degranulation is the foundation of the acute phase of allergic rhinitis (AR). Previously, downregulation of GATA binding protein 3 (GATA-3) was shown to suppress MC activation in an AR mouse model.
Yu-Qin Deng +6 more
doaj +1 more source
Critical Roles for Transcription Factor GATA-3 in Thymocyte Development [PDF]
, 2003 The transcription factor GATA-3 is expressed at every stage of thymic development, but its role in thymocyte differentiation is unknown. The fact that RAG chimeric animals lacking GATA-3 cannot generate early thymocytes from common lymphoid progenitors ...
Pai, Sung-Yun +11 more
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PLoS ONE, 2013 We previously reported that IL-3 signaling induces phosphorylation of GATA-1 at the serine²⁶ position, which contributes to IL-3-mediated anti-apoptotic response. Here, we demonstrate that phosphorylation of GATA-1 at serine²⁶ is also transiently induced
Kou-Ray Lin +3 more
doaj +1 more source
, 2004 Cytochrome P450c17 catalyzes steroidogenic 17alpha-hydroxylase and 17,20 lyase activities. Expression of the gene for P450c17 is cAMP dependent, tissue specific, developmentally programmed, and varies among species.
Miller, Walter L., Flück, Christa
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GATA3 (GATA binding protein 3) [PDF]
, 2012 Review on GATA3 (GATA binding protein 3), with data on DNA, on the protein encoded, and where the gene is ...
Bouchard, M, Tremblay, M
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Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus [PDF]
, 1996 The myosin light-chain 1/3 locus (MLC1/3) is regulated by two promoters and a downstream enhancer element which produce two protein isoforms in fast skeletal muscle at distinct stages of mouse embryogenesis. We have analyzed the expression of transcripts
McGrew, M J; id_orcid +5 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa-3
, 2011 And A", respectively). The insets in A, A' and A" represent magnifications of cardiac glands. GATA-4 and GATA-6 are strongly expressed in neuroendocrine cell hyperplasia (B and B', respectively) in contrast to no or little expression of Ihh (B").
Mia Westerholm-Ormio (68952) +6 more
core +1 more source