Results 51 to 60 of about 18,250,723 (243)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Expression and Genetic Interaction of Transcription Factors GATA-2 and GATA-3 during Development of the Mouse Central Nervous System [PDF]

, 1999
Here we examine the expression of transcription factors GATA-2 and GATA-3 during early stages of embryonic development in the central nervous system (CNS) of the mouse.
Fujiwara, Yuko, Tsai, Fong-Ying, Orkin, Stuart H., Nardelli, Jeannette, Thiesson, Danielle   +4 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa-3

, 2011
And A", respectively). The insets in A, A' and A" represent magnifications of cardiac glands. GATA-4 and GATA-6 are strongly expressed in neuroendocrine cell hyperplasia (B and B', respectively) in contrast to no or little expression of Ihh (B").
Mia Westerholm-Ormio (68952), Markku Mäki (68954), Markku Heikinheimo (68957), Erkki Savilahti (68955), Leif C Andersson (68956), Hanna Haveri (68951), Katri Lindfors (68953)   +6 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Physical and Functional Interaction between GATA-3 and Smad3 Allows TGF-β Regulation of GATA Target Genes [PDF]

, 2002
Background: Members of the GATA family of zinc finger transcription factors are genetically controlled “master” regulators of development in the hematopoietic and nervous systems.
Blokzijl, Andries, Carlos F. Ibáñez, Ibáñez, Carlos F., Peter ten Dijke, ten Dijke, Peter, Andries Blokzijl   +5 more
core   +2 more sources

GATA-3 and Its Association with Allergic Diseases and Immune Regulation: A Systematic Review

International Journal of Translational Medicine
Background/Objectives: GATA-binding protein 3 (GATA-3) is a crucial transcription factor that drives type 2 immune responses, and it is actively involved in allergic conditions such as asthma, allergic rhinitis (AR), and atopic dermatitis (AD).
Jamal Nasser Saleh Al-Maamari, Junaidi Khotib, Mahardian Rahmadi, Yusuf Alif Pratama, Nadia Ahmed Nasser Hosrom   +4 more
doaj   +1 more source

Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region. [PDF]

PLoS ONE, 2016
The T helper type 2 (Th2) locus control region (LCR) regulates Th2 cell differentiation. Several transcription factors bind to the LCR to modulate the expression of Th2 cytokine genes, but the molecular mechanisms behind Th2 cytokine gene regulation are ...
Kiwan Kim, Najung Kim, Gap Ryol Lee
doaj   +1 more source

Identification, Characterization, and Expression Profiling of Maize GATA Gene Family in Response to Abiotic and Biotic Stresses

Agronomy, 2023
GATA transcription factor is crucial for plant growth and development, physiological metabolism, and environmental response, which has been reported in many plants.
Yuchao Hu, Jingyi Huang, Li Yu, Changjin Wang, Xinwei Zhang, Xinxin Cheng, Haibing Yu, Kaijing Zhang   +7 more
doaj   +1 more source