Results 71 to 80 of about 18,362,222 (202)

Mechanism of RNA‐Binding Protein ELAVL1 in Promoting Th2 Cell Differentiation Through Stabilizing CPA3 mRNA in Allergic Rhinitis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to elucidate the role of the RNA‐binding protein embryonic lethality abnormal vision‐like protein 1 (ELAVL1) in the pathogenesis of allergic rhinitis (AR), specifically by investigating its potential to promote T helper 2 (Th2) cell differentiation by regulating the stability of carboxypeptidase A3 (CPA3) mRNA.
Meng‐Ya Liu, Hong‐Bing Yao, Cheng Chen   +2 more
wiley   +1 more source

Expression and Significance of GATA-3, H3K27me3 in Tibetan Patients with Bladder Urothelial Carcinoma

Xiehe Yixue Zazhi
ObjectiveTo investigate the expression and clinical significance of GATA-3 and H3K27me3 in Tibetan patients with bladder urothelial carcinoma (BUC).MethodsBUC and normal bladder tissues were collected retrospectively from January 2016 to December 2021 in
NIMA Zhuoma, XIAO Yu, LUO Hanhuan, DUO Bula, WANG Han, DA Zhen, SILANG Jiangcun, GUO Pingping, LIAO Ruiqian   +8 more
doaj   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. [PDF]

, 1997
We previously demonstrated that the zinc finger transcription factors GATA-2 and GATA-3 are expressed in trophoblast giant cells and that they regulate transcription from the mouse placental lactogen I gene promoter in a transfected trophoblast cell line.
Linzer, D.I.H. (Daniel), Orkin, S.H. (Stuart), Groskopf, JC, Ma, GT, Engel, JD, Roth, ME, Linzer, DIH, Roth, M.E. (Matthew), Groskopf, J.C. (John), Tsai, F.Y. (Fong-Ying), Engel, J.D. (Douglas), Orkin, SH, Grosveld, Frank, Ma, G.T. (Grace), Grosveld, F.G. (Frank), Tsai, FY   +15 more
core   +1 more source

Molecular and evolutionary analysis of the GATA transcription factor family

, 2003
The objective of this research has been to characterize the evolution of the GATA family of transcription factors through phylogenetic, molecular, and biochemical analyses. From a phylogenetic perspective, we address three major questions.
Lowry, Jason Allen
core  

Regulation of thrombopoietin receptor expression and function [PDF]

, 2004
Of the many cells in the body, the hematopoietic cells are among those with the highest rate of self-renewal and turnover. The production and destruction of these cells are tightly controlled by a number of hematopoietic growth factors, in particular by ...
Coers, Jörn
core   +1 more source

Evaluating Thiram‐Induced Embryotoxicity Using Integrated In Silico, In Vitro, and Transcriptomic Approaches

Environmental Toxicology, EarlyView.
ABSTRACT Long‐term exposure to low‐dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight‐of‐evidence computational model, which predicted 127 chemicals to be of high concern.
Chia‐Chi Ho, Chun‐Wei Tung, B. Linju Yen, Chen‐Yi Weng, Ju‐Hsin Hsu, Ming‐Hsien Tsai, Salim Arrokhman, Pinpin Lin   +7 more
wiley   +1 more source

GATA 3 BELİRTECİ MESANE KANSERİ NÜKSÜNÜ VE PROGRESYONUNU ÖNGEREBİLİR Mİ?

, 2023
Amaç: GATA 3 hücre içi transkripsiyondan sorumlu olan bir proteindir. Hem mesane kanseripatogenezinde hem de kanserin seyrinde etkili olduğu bilinmektedir.
Mungan, Mehmet Uğur, Tuna, Emine Burçin, Kefi, Aykut, Aslan, Güven, Yörükoğlu, Kutsal, Esen, Ahmet Adil, Özer, Muhammed Selçuk, Doğan, Barış, Şen, Volkan, Çelebi, İlhan, Bozkurt, Ozan   +10 more
core   +1 more source

Safety, Efficacy, and Mechanism of Action of Budesonide in Rhinitis and Rhinosinusitis: A Systematic Review

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and ...
David W. Kennedy, Lei Cheng, De‐Yun Wang   +2 more
wiley   +1 more source

Papillary Thyroid Cancer With Cutaneous Metastasis: A Case Report and Literature Review

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cutaneous metastasis of papillary thyroid carcinoma is rare, which may present as slowly growing nodules, erythematous papules, or ulcerative nodules. The pathophysiological mechanisms of skin metastasis in thyroid cancer remain unclear.
Yi‐Qing Gao, Xin‐Lu Yin, Lu‐Ying Zheng, Jia‐Dong Wang   +3 more
wiley   +1 more source