Results 91 to 100 of about 18,250,723 (243)
Environmental Toxicology, EarlyView.ABSTRACT Long‐term exposure to low‐dose food contact materials (FCMs) has raised concerns regarding developmental toxicity. In the present study, we prioritized FCMs with potential developmental toxicity using a weight‐of‐evidence computational model, which predicted 127 chemicals to be of high concern.
Chia‐Chi Ho +7 more
wiley +1 more source
GATA 3 BELİRTECİ MESANE KANSERİ NÜKSÜNÜ VE PROGRESYONUNU ÖNGEREBİLİR Mİ?
, 2023 Amaç: GATA 3 hücre içi transkripsiyondan sorumlu olan bir proteindir. Hem mesane kanseripatogenezinde hem de kanserin seyrinde etkili olduğu bilinmektedir.
Mungan, Mehmet Uğur +10 more
core +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and ...
David W. Kennedy +2 more
wiley +1 more source
Papillary Thyroid Cancer With Cutaneous Metastasis: A Case Report and Literature Review
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Cutaneous metastasis of papillary thyroid carcinoma is rare, which may present as slowly growing nodules, erythematous papules, or ulcerative nodules. The pathophysiological mechanisms of skin metastasis in thyroid cancer remain unclear.
Yi‐Qing Gao +3 more
wiley +1 more source
Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions
Allergy, EarlyView.Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira +13 more
wiley +1 more source
OncoImmunology, 2019 Intravesical Bacille Calmette-Guérin (BCG) remains the most effective treatment for high-risk non-muscle-invasive bladder cancer (NMIBC), unfortunately there is no validated biomarker to predict clinical outcome.
Roberto Martínez +12 more
doaj +1 more source
GATA-3 suppresses IFN-γ promoter activity independently of binding to cis-regulatory elements [PDF]
, 2004 The regulatory mechanism by which GATA-3 suppresses IFN-γ gene expression was investigated. A reduction of GATA-3 using RNA interference technology enhanced, whereas overexpression of GATA-3 suppressed IFN-γ mRNA expression.
Kazunari Taira +15 more
core +1 more source
Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination
Allergy, EarlyView.We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera +14 more
wiley +1 more source
, 2013 Both T-bet and GATA-3, Th1/Th2 lineage-specific transcription factors, play important roles in the development of T cells and Th1/Th2 differentiation. In this study, T-bet and GATA-3 genes were cloned from grass carp (Ctenopharyngodon idellus).
Guo, Qionglin +5 more
core +1 more source
Spindle Cell Lesions of the Breast: A 12‐Year Experience
ANZ Journal of Surgery, EarlyView.This 12‐year, single‐centre study examined 30 core‐biopsy‐diagnosed breast spindle cell lesions (BrSCL), classified as atypical (ASCL, n = 10) or bland (BSCL, n = 20). Following excision, 80% of ASCLs proved malignant, comprising sarcoma, malignant phyllodes tumour and metaplastic carcinoma.
Shalvin Jassal +4 more
wiley +1 more source